Results 251 to 260 of about 478,848 (342)

Enhancing the Effectiveness of Chemotherapy in Osteosarcoma by Targeting Tumour‐Associated Macrophages (TAMs) through STING Activation

Advanced Therapeutics, EarlyView.
Osteosarcoma isa highly aggressive bone cancer with an immunosuppressive tumor microenvironment that limits immunotherapy. This study explores STING pathway activation to reprogram tumor‐associated macrophages into a tumoricidal M1‐like phenotype and enhance doxorubicin efficacy. Results show that doxorubicin alone failed to activate the STING pathway,
Jordan C. O'Donoghue, Amanda Guitián‐Caamaño, Maeve Boyce, Fiona E. Freeman   +3 more
wiley   +1 more source

Altered responsiveness to chemokines due to targeted disruption of SHIP

, 1999
Chang H. Kim, Giao Hangoc, Stephanie Cooper, Cheryl D. Helgason, Sandie Yew, R. Keith Humphries, Gerald Krystal, Hal E. Broxmeyer   +7 more
openalex   +1 more source

Loss of NR2F6 Protects from Salmonella Typhimurium Infection

Advanced Science, EarlyView.
Loss of nuclear receptor NR2F6 reduces tissue‐resident macrophage populations. Nr2f6‐deficient mice are protected from weight loss and bacterial load during infection with Salmonella Typhimurium. Pro‐inflammatory cytokines and iron levels are altered in infected Nr2f6‐deficient mice.
Johannes Woelk, Christa Pfeifhofer‐Obermair, Julia Benz, Natascha Brigo, Milena Bamberger, Alexeja Kleiter, Martin Hermann, Guenter Weiss, Natascha Hermann‐Kleiter   +8 more
wiley   +1 more source

ST6GAL1‐Mediated Sialylation Stabilizes PD‐L1 and Drives Immunosuppressive Tumor Microenvironment in Colorectal Cancer

Advanced Science, EarlyView.
ST6GAL1 plays a critical role in tumor progression and immune regulation in colorectal cancer (CRC). Its depletion significantly suppresses the malignant phenotype of CRC cells and enhances the efficacy of anti‐PD‐L1 therapy. High ST6GAL1 expression promotes an immune‐activated tumor microenvironment (TME), characterized by increased infiltration of ...
Ximo Xu, Jingyi Liu, Wei Qin, Chengsheng Ding, Zhenghao Cai, Duohuo Shu, Hao Zhong, Yanyan Hu, Mengqin Yu, Leqi Zhou, Jianwen Li, Minhua Zheng, Bin Li, Sen Zhang, Xiao Yang, Bo Feng   +15 more
wiley   +1 more source

Research progress on the regulation of autophagy in cardiovascular diseases by chemokines. [PDF]

Open Life Sci
Ma J, Tan X, Feng J, Li Z, Tan S, Li B, Zhao L.   +6 more
europepmc   +1 more source

Glucose Deprivation‐Induced Disulfidptosis via the SLC7A11‐INF2 Axis: Pan‐Cancer Prognostic Exploration and Therapeutic Validation

Advanced Science, EarlyView.
Glucose deprivation or GLUT1 inhibition induces disulfidptosis in SLC7A11high ovarian cancer cells by promoting cystine accumulation, NADPH/ATP depletion, and F‐actin disulfide formation. SLC7A11 interacts with INF2 to further increase H₂O₂ levels and impair mitochondrial fission, suppressing cell migration. Targeting the SLC7A11–INF2 axis represents a
Zhenyu Song, Qiuming Yao, Lina Huang, Dan Cui, Jun Xie, Leilei Wu, Jianfeng Huang, Bo Zhai, Dan Liu, Xiao Xu   +9 more
wiley   +1 more source

Impact of Smoking on Macrophage-Related Chemokines During Initial Peri-Implantitis: A Prospective Cohort Study. [PDF]

Clin Implant Dent Relat Res
Altay BNB, Cankaya ZT, Yilmaz M, Gürsoy M, Bodur A, Gürsoy UK.   +5 more
europepmc   +1 more source

A Broad Range of Chemokine Receptors Are Used by Primary Isolates of Human Immunodeficiency Virus Type 2 as Coreceptors with CD4

, 1998
Àine McKnight, Matthias T. Dittmar, José Moniz-Periera, Koya Ariyoshi, Jacqueline D. Reeves, Sam Hibbitts, Denise Whitby, Emma Aarons, Amanda E. I. Proudfoot, Hilton Whittle, Paul R. Clapham   +10 more
openalex   +1 more source

Cathepsin K Aggravates Pulmonary Fibrosis Through Promoting Fibroblast Glutamine Metabolism and Collagen Synthesis

Advanced Science, EarlyView.
CTSK plays a critical role in pulmonary fibrosis. Excessive CTSK accumulation interacts with SNX9 to enhance TGF‐β1‐induced SMAD3 activation and GLS1 expression in fibroblasts, driving glutamine metabolism for collagen biosynthesis and exacerbating pulmonary fibrosis.
Mengting Chen, Xiaoxiao Meng, Yong Zhu, Dapeng Wang, Mengmeng Wang, Ziyuan Wang, Xue Tian, Jiaxiang Zhang, Zhiying Yue, Zhengfeng Yang, Ruilan Wang   +10 more
wiley   +1 more source

Reduced Platelet Aggregation and Plasma Cytokine Levels Mitigate Progressive Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). [PDF]

J Inflamm Res
Harm T, Rohlfing AK, Henes JK, Manzat N, Droppa M, Bongers MN, Heikenwaelder M, Müller KAL, Gawaz MP, Rath D.   +9 more
europepmc   +1 more source