Results 51 to 60 of about 86,546 (282)

RIPK3 restricts viral pathogenesis via cell death-independent neuroinflammation [PDF]

, 2017
Receptor-interacting protein kinase-3 (RIPK3) is an activator of necroptotic cell death, but recent work has implicated additional roles for RIPK3 in inflammatory signaling independent of cell death.
Daniels, Brian P., Gale, Michael, Loo, Yueh-Ming, Martinez, Jennifer, Oberst, Andrew, Oguin III, Thomas H., Olsen, Tayla M., Orozco, Susana, Snyder, Annelise G., Tait, Stephen W.G.   +9 more
core   +1 more source

Perivascular adipose tissue inflammation in vascular disease [PDF]

, 2017
Perivascular adipose tissue (PVAT) plays a critical role in the pathogenesis of cardiovascular disease. In vascular pathologies, perivascular adipose tissue increases in volume and becomes dysfunctional, with altered cellular composition and molecular ...
Guzik, Tomasz J., Nosalski, Ryszard
core   +1 more source

CCL2 Chemokine as a Potential Biomarker for Prostate Cancer: A Pilot Study [PDF]

Cancer Research and Treatment, 2014
Prostate specific antigen is not reliable in diagnosing prostate cancer (PCa), making the identification of novel, precise diagnostic biomarkers important. Since chemokines are associated with more aggressive disease and poor prognosis in diverse malignancies, we aimed to investigate the diagnostic relevance of chemokines in PCa.Preoperative and early ...
Tsaur, Igor, Noack, Anika, Makarević, Jasmina, Oppermann, Elsie, Waaga, Ana Maria da Silva Rosa, Gasser, Martin, Borgmann, Hendrik, Huesch, Tanja, Gust, Kilian, Reiter, Michael Andreas, Schilling, David, Bartsch, Georg, Haferkamp, Axel, Blaheta, Roman A.   +13 more
openaire   +3 more sources

Loss of Transforming Growth Factor-β Signaling in Mammary Fibroblasts Enhances CCL2 Secretion to Promote Mammary Tumor Progression through Macrophage-Dependent and -Independent Mechanisms

Neoplasia: An International Journal for Oncology Research, 2010
Whereas the accumulation of fibroblasts and macrophages in breast cancer is a well-documented phenomenon and correlates with metastatic disease, the functional contributions of these stromal cells on breast cancer progression still remain largely unclear.
Stacey L. Hembruff, Iman Jokar, Li Yang, Nikki Cheng   +3 more
doaj   +1 more source

Interference of the T cell and antigen-presenting cell costimulatory pathway using CTLA4-Ig (abatacept) prevents Staphylococcal enterotoxin B pathology [PDF]

, 2017
Staphylococcal enterotoxin B (SEB) is a bacterial superantigen that binds the receptors in the APC/T cell synapse and causes increased proliferation of T cells and a cytokine storm syndrome in vivo.
Carter, Alun J, Green, A. Christopher, Griffiths, Gareth D, Jones, James T.A., Rijpkema, Sjoerd, Risdall, Jane E, Saraiva, Luisa, Taylor, Chris, Vessillier, Sandrine, Whitfield, Sarah J.C., Williamson, E. Diane   +10 more
core   +2 more sources

Immune response CC chemokines CCL2 and CCL5 are associated with pulmonary sarcoidosis [PDF]

Fibrogenesis & Tissue Repair, 2011
AbstractBackgroundPulmonary sarcoidosis involves an intense leukocyte infiltration of the lung with the formation of non-necrotizing granulomas. CC chemokines (chemokine (C-C motif) ligand 2 (CCL2)-CCL5) are chemoattractants of mononuclear cells and act through seven transmembrane G-coupled receptors.
Palchevskiy, Vyacheslav, Hashemi, Nastran, Weigt, Stephen S, Xue, Ying Ying, Derhovanessian, Ariss, Keane, Michael P, Strieter, Robert M, Fishbein, Michael C, Deng, Jane C, Lynch, Joseph P, Elashoff, Robert, Belperio, John A   +11 more
openaire   +4 more sources

CCL2-CCR2 Chemokine Signaling Facilitates Tumor Cell Extravasation [PDF]

Cancer Discovery, 2012
Abstract Tumor-derived CCL2 activates CCR2-expressing endothelium to enhance vascular permeability.
openaire   +1 more source

The effects of 4-week aerobic exercise on the levels of CCL2, CCL5, and their respective receptors in female BALB/C mice suffering from breast cancer

Advanced Biomedical Research, 2023
Background: The studies reported that chemokines Chemokine (C-C motif) ligand 2 (CCL2) and Chemokine (C-C motif) ligand 5 (CCL5) have tumor-promoting roles in breast cancer (BC).
Mehrnoosh Esmailiyan, Mehdi Kargarfard, Fahimeh Esfarjani, Golnaz Vaseghi, Shaghayegh Haghjooy Javanmard, Atefeh Amerizadeh   +5 more
doaj   +1 more source

Evaluation of the effect of GM-CSF blocking on the phenotype and function of human monocytes [PDF]

, 2020
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a multipotent cytokine that prompts the proliferation of bone marrow-derived macrophages and granulocytes.
Esmaeil, Nafiseh, Lotfi, Noushin, Rostami, Mohamad, Zhang, Guang-Xian   +3 more
core   +2 more sources

Identifying chemokines as therapeutic targets in renal disease: Lessons from antagonist studies and knockout mice [PDF]

, 2004
Chemokines, in concert with cytokines and adhesion molecules, play multiple roles in local and systemic immune responses. In the kidney, the temporal and spatial expression of chemokines correlates with local renal damage and accumulation of chemokine ...
Abdi R, Anders HJ, Anders HJ, Anders HJ, Bruhl H, Burne-Taney MJ, Feng L, Fituri O, Fujinaka H, Garcia GE, Grone HJ, Keane MP, Mack M, Miura M, Murphy PM, Nath KA, Perez de Lema G, Rollins BJ, Romagnani P, Segerer S, Segerer S, Segerer S, Tang WW, Taub DD, Tesch GH, Tokuda A, Topham PS, Vielhauer V, Vielhauer V, Wada T, Wang Y, Wenzel U, Wu X, Wu X, Zernecke A   +34 more
core   +1 more source