CC chemokine ligand 2 (CCL2) promotes prostate cancer tumorigenesis and metastasis [PDF]
Cytokine & Growth Factor Reviews, 2010 CCL2 is a chemokine known to recruit monocytes and macrophages to sites of inflammation. A growing body of research suggests CCL2 is progressively overexpressed in tumor beds and may play a role in the clinical progression of solid tumors. Cancer cells derived from several solid tumor types demonstrate functional receptors for CCL2, suggesting this ...
Jian, Zhang +2 more
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Frontiers in Immunology, 2020 Macrophages are key targets of human immunodeficiency virus type 1 (HIV-1) infection and main producers of the proinflammatory chemokine CC chemokine ligand 2 (CCL2), whose expression is induced by HIV-1 both in vitro and in vivo.
Daniela Angela Covino +15 more
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Cytokines and chemokines as regulators of skeletal muscle inflammation: presenting the case of Duchenne muscular dystrophy [PDF]
, 2013 Duchenne muscular dystrophy is a severe inherited muscle disease that affects 1 in 3500 boys worldwide. Infiltration of skeletal muscle by inflammatory cells is an important facet of disease pathophysiology and is strongly associated with disease ...
De Bleecker, Jan, De Paepe, Boel
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Immuno-pathomechanism of liver fibrosis: targeting chemokine CCL2-mediated HIV:HCV nexus [PDF]
Journal of Translational Medicine, 2014 حتى في عصر الجمع الناجح بين العلاج المضاد للفيروسات القهقرية (CART)، لا تزال العدوى المشتركة بفيروس التهاب الكبد الوبائي (HCV) أحد الأسباب الرئيسية للوفيات والمراضة غير المرتبطة بالإيدز بين الأفراد المصابين بفيروس نقص المناعة البشرية نتيجة لتسارع تليف الكبد ومرض الكبد في المرحلة النهائية (ESLD).
Abdul W. Ansari +3 more
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Placental chemokine compartmentalisation: A novel mammalian molecular control mechanism.
PLoS Biology, 2019 Atypical chemokine receptor 2 (ACKR2) is a chemokine-scavenging receptor. ACKR2-/-embryos display a reduction in size of a novel, to our knowledge, embryonic skin macrophage population referred to as 'intermediate' cells. CC chemokine receptor 2 (CCR2)-/-
Kit Ming Lee +7 more
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Journal of Translational Medicine, 2011 Background Infiltration of colorectal carcinomas (CRC) with T-cells has been associated with good prognosis. There are some indications that chemokines could be involved in T-cell infiltration of tumors.
Meropol Neal J +7 more
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CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis [PDF]
, 2011 Macrophages abundantly found in the tumor microenvironment enhance malignancy(1). At metastatic sites a distinct population of metastasis associated macrophages (MAMs) promote tumor cell extravasation, seeding and persistent growth(2).
AB Al-Mehdi +32 more
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The Role of Serum CC-Chemokine Ligand 2 (CCL2) in Obesity: A Comparative Study with Normal Subjects [PDF]
BIO Web of ConferencesExcess fat in the visceral area in the form of obesity is associated with metabolic syndrome. Various factors have been identified that contribute to the pathophysiology of obesity-related metabolic diseases, including chronic inflammatory factors and ...
Lestarini Asri +3 more
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Targeting interleukin-1β protects from aortic aneurysms induced by disrupted transforming growth factor β signaling [PDF]
, 2017 Aortic aneurysms are life-threatening conditions with effective treatments mainly limited to emergency surgery or trans-arterial endovascular stent grafts, thus calling for the identification of specific molecular targets.
Bizzotto, Dario +13 more
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The significance of macrophage polarization subtypes for animal models of tissue fibrosis and human fibrotic diseases. [PDF]
, 2015 The systemic and organ-specific human fibrotic disorders collectively represent one of the most serious health problems world-wide causing a large proportion of the total world population mortality.
Ballater R +32 more
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