Results 121 to 130 of about 49,192 (255)

Chemokine CXCL12 drives pericyte accumulation and airway remodeling in allergic airway disease. [PDF]

Respir Res, 2022
Bignold R, Shammout B, Rowley JE, Repici M, Simms J, Johnson JR.   +5 more
europepmc   +1 more source

S-Geranylgeranyl-L-glutathione is a ligand for human B cell-confinement receptor P2RY8. [PDF]

, 2019
Germinal centres are important sites for antibody diversification and affinity maturation, and are also a common origin of B cell malignancies. Despite being made up of motile cells, germinal centres are tightly confined within B cell follicles. The cues
Cyster, Jason G, Lu, Erick, Muppidi, Jagan R, Wolfreys, Finn D, Xu, Ying   +4 more
core   +1 more source

The Differentiation Balance of Bone Marrow Mesenchymal Stem Cells Is Crucial to Hematopoiesis. [PDF]

, 2018
Bone marrow mesenchymal stem cells (BMSCs), the important component and regulator of bone marrow microenvironment, give rise to hematopoietic-supporting stromal cells and form hematopoietic niches for hematopoietic stem cells (HSCs).
Li, Shengwen Calvin, Li, Zhongjun, Ran, Qian, Wu, Jiang, Xiang, Yang, Zhang, Weiwei, Zhong, Jiang F   +6 more
core   +2 more sources

Mesenchymal stromal cell therapy for rheumatoid arthritis: Long‐term efficacy, safety, and mechanistic insights

Rheumatology &Autoimmunity, EarlyView.
Graphical abstract summarizing the multifactorial pathogenesis of rheumatoid arthritis (RA) and the therapeutic potential of mesenchymal stromal cell (MSC) therapy. MSCs provide promising benefits through their immunomodulatory properties, low immunogenicity, ability to promote tissue repair, and multi‐lineage differentiation, presenting a potential ...
Yingjia Chen, Ruiyu Gao, Xing Guo, Genhong Yao, Xiaojun Tang, Yile E. Liu, Lingyun Sun   +6 more
wiley   +1 more source

Trisubstituted 1,3,5-Triazines: The First Ligands of the sY12-Binding Pocket on Chemokine CXCL12. [PDF]

ACS Med Chem Lett, 2021
Sprague DJ, Getschman AE, Fenske TG, Volkman BF, Smith BC.   +4 more
europepmc   +1 more source

Brain Pericytes and Wnt/β‐Catenin Signaling Induce Functional Blood–Brain Barrier Phenotype in Human iPSC‐Derived Model

Small Methods, EarlyView.
This study shows that human iPSC‐derived endothelial cells acquire a functional blood–brain barrier phenotype when co‐cultured with brain pericytes and stimulated with CHIR‐99021, a Wnt/β‐catenin activator. This model recapitulates key barrier properties, inflammatory responses, and transcriptomic features of the native human BBB, offering new ...
Henrique Nogueira Pinto, Nine R. Kok, Philipp C. Hauger, Manon Karsten‐van Diepen, Michael de Kok, Nanne J. Paauw, Susanne M. A. van der Pol, Joline P. Nugteren‐Boogaard, Peter L. Hordijk, Stephanie D. Beekhuis‐Hoekstra, Susan Gibbs, Nienke M. de Wit, Helga E. de Vries   +12 more
wiley   +1 more source

CXCL14 antagonizes the CXCL12-CXCR4 signaling axis

Biomolecular Concepts, 2014
CXCL12 and CXCL14 are evolutionarily conserved members of the CXC-type chemokine family. CXCL12 binds specifically to the G-protein-coupled receptor CXCR4 to induce the migration of primordial germ cells, hematopoietic stem cells, and inflammation ...
Hara Takahiko, Tanegashima Kosuke
doaj   +1 more source

Mechanisms of HIV-1 evasion to the antiviral activity of chemokine CXCL12 indicate potential links with pathogenesis. [PDF]

PLoS Pathog, 2021
Armani-Tourret M, Zhou Z, Gasser R, Staropoli I, Cantaloube-Ferrieu V, Benureau Y, Garcia-Perez J, Pérez-Olmeda M, Lorin V, Puissant-Lubrano B, Assoumou L, Delaugerre C, Lelièvre JD, Lévy Y, Mouquet H, Martin-Blondel G, Alcami J, Arenzana-Seisdedos F, Izopet J, Colin P, Lagane B.   +20 more
europepmc   +1 more source

Agarose Spot as a Comparative Method for in situ Analysis of Simultaneous Chemotactic Responses to Multiple Chemokines [PDF]

, 2017
yesWe describe a novel protocol to quantitatively and simultaneously compare the chemotactic responses of cells towards different chemokines. In this protocol, droplets of agarose gel containing different chemokines are applied onto the surface of a ...
A Antonelli, A Ben-Baruch, A Guyon, A Kalinowska, A Mantovani, A Muller, A Viola, A Zlotnik, A Zlotnik, AC Szatmary, AJ Muinonen-Martin, B Heit, C Gerard, CH Wong, CJ Hutchings, D Raman, D Zicha, DJ Scholten, E Clercq De, F Balkwill, F Balkwill, G Lazennec, GE White, H Kimura, H Kulbe, H Wiggins, IF Charo, J Kodama, J Pease, JE Pease, JE Pease, JM Ayuso, K Princen, KL Hulkower, L Bruni, L Greiff, L He, M Allegretti, M Eberhardson, M Kimura, M Okamoto, M Yoshida, MN Darisipudi, MR Jerath, N Godessart, N Ibarra, N Kramer, PD Cravens, PH Carter, PJ Koelink, PL Wagner, QH Zhao, RE Kohler, RR Koenen, S Boyden, S Kodati, S Ramanujan, SH Zigmond, SP Fricker, SS Lee, T Arigami, T Kakinuma, U Haessler, V Vinader, V Vinader, Y Kakuta, Y Liu, Y Zhang   +67 more
core   +2 more sources

Allergic Sensitization to Inhalant Allergens in the Upper Respiratory Tract—the B Cell Side

Allergy, EarlyView.
ABSTRACT Allergic diseases are on the rise worldwide, driven by respiratory epithelial barrier dysfunction that promotes sensitization to inhalant allergens such as pollen, dust mites, pet dander, and fungal spores. These antigens trigger IgE‐mediated immune responses that lead to diseases such as allergic rhinitis (AR) and asthma.
Ola Grimsholm, Mohammed Zghaebi, Bita Hambrecht, Tanja Kalic, Christopher C. Udoye, Rudolf Manz, Barbara Bohle, Katarzyna M. Sitnik, Julia Eckl‐Dorna, Heimo Breiteneder   +9 more
wiley   +1 more source