Results 131 to 140 of about 33,556 (238)

KPNA2 Drives Immunosuppression in Ovarian Cancer via CCL2/CCR2‐Dependent MDSC Recruitment

Cancer Science, EarlyView.
KPNA2 drives intratumoral MDSC accumulation and immunosuppression in ovarian cancer via the NF‐κB/CCL2/CCR2 axis. Mechanistically, KPNA2 facilitates NF‐κB/p65 nuclear translocation and induces CCL2 transcription, recruiting MDSCs to establish an immunosuppressive microenvironment.
Qingli Li, Jitong Zhao, Lu Yang, Lin Li, Ce Bian, Tao Yi, Huiqiong Huang, Gang Zheng, Xiaojuan Lin   +8 more
wiley   +1 more source

Dose‐dependent Effect of Statin Therapy on Circulating CXCL12 Levels in Patients with Hyperlipidemia

Clinical and Translational Medicine, 2012
Background HMG‐CoA reductase inhibitors (statins) have pleiotropic effects that are independent of cholesterol‐lowering, including a dose‐dependent effect on angiogenesis.
Will Camnitz, Marie D Burdick, Robert M Strieter, Borna Mehrad, Ellen C Keeley   +4 more
doaj   +1 more source

Mitochondrial transfer in acute myeloid leukaemia and multiple myeloma: Mechanisms, consequences and potential therapeutic opportunities

The FEBS Journal, EarlyView.
Mitochondria can be transferred from bone marrow cells to cancer cells in acute myeloid leukaemia and multiple myeloma, boosting tumour energy production, growth, and drug resistance. This review highlights key transfer mechanisms and shows how targeting mitochondrial movement and dynamics may offer new therapeutic strategies to limit cancer ...
Ebubechukwu Nwarunma, Mark T. S. Williams   +1 more
wiley   +1 more source

Structural insights into tyrosine sulfation of CCR5 by human tyrosylprotein sulfotransferase‐1

The FEBS Journal, EarlyView.
Structural analysis of human tyrosylprotein sulfotransferase‐1 (hTPST1) bound to a CCR5 N‐terminal peptide reveals how hTPST1 recognizes the Tyr3 sulfation site. Structure‐guided models of additional CCR5 sulfation states and full‐length assemblies provide a framework for understanding CCR5 tyrosine sulfation, a post‐translational modification relevant
Shinnosuke Tanaka, Hirai Asano, Kota Toyoda, Toshiaki Nishiyori, Hidetaka Kojo, Kazuto Kiyomatsu, Katsuhisa Kurogi, Yoichi Sakakibara, Etsuko Nishimoto, Takamasa Teramoto, Yoshimitsu Kakuta   +10 more
wiley   +1 more source

The Interplay of M1 Macrophages and Dental Pulp Stem Cells Promotes Angiogenesis Through IL‐8‐Dependent VEGF Regulation: An In Vitro Study

International Endodontic Journal, EarlyView.
ABSTRACT Background Dental pulp inflammation triggers immune responses involving macrophages and dental pulp stem cells (DPSCs), which interact to regulate angiogenesis essential for tissue repair. M1 pro‐inflammatory macrophages predominate early in pulpitis, and clarifying their angiogenic role is vital in identifying inflammatory regenerative ...
Dineshi Sewvandi Thalakiriyawa, Mohamad Koohi‐Moghadam, Mingxin Hu, Hong Wang, Colman McGrath, Waruna Lakmal Dissanayaka   +5 more
wiley   +1 more source

Tocilizumab for severe and refractory mucous membrane pemphigoid

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Elevated IL‐6 levels identified in mucous membrane pemphigoid support IL‐6 blockade, with tocilizumab demonstrating clinical benefit in nine patients with severe and refractory mucous membrane pemphigoid. Abstract Background Mucous membrane pemphigoid (MMP) is a rare autoimmune blistering disease involving mucous membranes with a potentially ...
Billal Tedbirt, Maud Maho‐Vaillant, Julie Gueudry, Marie‐Laure Golinski, Marion Marcaillou, Blanche Bergeret, Guillaume Chambon, Pierre Bouchetemble, Soumeya Bekri, Abdellah Tebani, Hervé Maillard, Cécile Morice, Anais Vautier, Edgar‐Pierre Libert, Christelle Le Roux‐Villet, Marion Carrette, Olivier Boyer, Vivien Hébert, Sébastien Calbo, André Gillibert, Pascal Joly   +20 more
wiley   +1 more source

Sulfopeptide probes of the CXCR4/CXCL12 interface reveal oligomer-specific contacts and chemokine allostery

, 2013
Tyrosine sulfation is a post-translational modification that enhances protein–protein interactions and may identify druggable sites in the extracellular space.
Bryan Stephens (515767), Deni Taleski (1908802), Irina Kufareva (379208), Tracy M. Handel (245262), Joshua J. Ziarek (1337256), Anthony E. Getschman (1344852), Richard J. Payne (401410), Stephen Butler (1250373), Brian F. Volkman (502457)   +8 more
core  

Truncation of CXCL12 by CD26 reduces its CXC chemokine receptor 4- and atypical chemokine receptor 3-dependent activity on endothelial cells and lymphocytes.

, 2017
The chemokine CXCL12 or stromal cell-derived factor 1/SDF-1 attracts hematopoietic progenitor cells and mature leukocytes through the G protein-coupled CXC chemokine receptor 4 (CXCR4).
Janssens, Rik, Noppen, Sam, Daiane Boff, Struyf, Sofie, Sofie Struyf, Marc Parmentier, Jo Van Damme, Boff, Daiane, Noppen, Samuel, Teixeira, Mauro M, Van Damme, Jozef, Paul Proost, Flávio A. Amaral, Mette M. Rosenkilde, Rosenkilde, Mette M, Mauro M. Teixeira, Amaral, Flávio A, Rik Janssens, Mortier, Anneleen, Viktorija Daugvilaite, Sam Noppen, Rosenkilde, Mette M., Mieke Gouwy, Parmentier, Marc, Ruytinx, Pieter, Olav Larsen, Proost, Paul, Pieter Ruytinx, Vantilt, Bo, Amaral, Flávio A., Bo Vantilt, Anneleen Mortier, Sandra Liekens, Rosenkilde, Mette MM, Liekens, Sandra, Van Damme, Jo, Gouwy, Mieke, Teixeira, Mauro M., Larsen, Olav, Daugvilaite, Viktorija   +39 more
core   +1 more source

Elevated plasma CXCL12 leads to pain chronicity via positive feedback upregulation of CXCL12/CXCR4 axis in pain synapses

The Journal of Headache and Pain
Background Chronic pain poses a clinical challenge due to its associated costly disability and treatment needs. Determining how pain transitions from acute to chronic is crucial for effective management.
Shi-Ze Leng, Mei-Jia Fang, Yi-Min Wang, Zhen-Jia Lin, Qian-Yi Li, Ya-Nan Xu, Chun-Lin Mai, Jun-Ya Wan, Yangyinhui Yu, Ming Wei, Ying Li, Yu-Fan Zheng, Kai-Lang Zhang, Ya-Juan Wang, Li-jun Zhou, Zhi Tan, Hui Zhang   +16 more
doaj   +1 more source

Inflammation and mechanical force‐induced bone remodeling

Periodontology 2000, EarlyView.
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon, Xin Huang, Leticia Rojas Cortez, Puttipong Sripinun, Jung‐me Lee, Julie J. Hong, Dana T. Graves   +6 more
wiley   +1 more source