Results 161 to 170 of about 33,556 (238)

Cxcl12 evolution – subfunctionalization of a ligand through altered interaction with the chemokine receptor [PDF]

, 2019
The active migration of primordial germ cells (PGCs) from their site of specification towards their target is a valuable model for investigating directed cell migration within the complex environment of the developing embryo.
Dörries, Julia, Schwille, Petra, Laguri, Cedric, Brand, Michael, Lortat-Jacob, Hugues, Thelen, Sylvia, Raz, Erez, Messerschmidt, Esther-Maria, Doitsidou, Maria, Yu, Shuizi Rachel, Boldajipour, Bijan, Tarbashevich, Katsiaryna, Ries, Jonas, Thelen, Marcus, Dumstrei, Karin   +14 more
core  

Super‐Enhancer Formation in Scirrhous Gastric CAFs, and the Presence of a Stromal Field in Non‐Cancerous Tissues

Cancer Science, Volume 117, Issue 7, Page 1894-1906, July 2026.
While CAFs are produced as a result of education by cancer cells in non‐scirrhous gastric cancer, normal fibroblasts of scirrhous gastric cancer patients are already pre‐conditioned, forming a stromal field for scirrhous gastric cancer. ABSTRACT Scirrhous gastric cancer has aggressive clinical courses and is characterized by dominating cancer ...
Yoshimi Yasukawa, Naoko Hattori, Yu‐Yu Liu, Masayuki Tobo, Genki Yamagishi, Takahiro Irie, Shigeki Sekine, Tohru Kiyono, Satoshi Yamashita, Yukinori Yamagata, Takaki Yoshikawa, Yasuyuki Seto, Toshikazu Ushijima   +12 more
wiley   +1 more source

The CXCL12/CXCR4 Axis: An Emerging Therapeutic Target for Chronic Pain

Journal of Pain Research
Zhangwei Chen, Yunfan Xia, Boyi Liu, Jianqiao Fang, Qimiao Hu The Third School of Clinical Medicine (School of Rehabilitation Medicine), Zhejiang Chinese Medical University, Hangzhou, People’s Republic of ChinaCorrespondence: Qimiao Hu, The Third School ...
Chen Z, Xia Y, Liu B, Fang J, Hu Q
doaj  

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, Volume 293, Issue 13, Page 3717-3757, July 2026.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Role of chemokine CXCL12 and action of chalcones molecules in the self-renewal and survival of glioblastoma initiator cells

, 2020
La chimiokine CXCL12 et ses récepteurs CXCR4 et ACKR3, constituent une voie de signalisation dont l'importance est reconnue dans le développement des glioblastomes.
Hajjar, Farah
core  

The role of the CXCR4-CXCL12 chemokine axis in melanoma metastasis to the normal and fibrotic liver [PDF]

, 2014
PhD ThesisMalignant melanoma represents the most aggressive form of skin cancer. Although early stage disease is treatable through surgical excision alone, late stage tumours frequently metastasise to the liver, at which point treatment options remain ...
Swidenbank, Isabella
core  

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, Volume 293, Issue 13, Page 3899-3953, July 2026.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

Thymus and Leishmania at the Crossroads: Autoimmunity and Cancer

Immunology, Volume 178, Issue 3, Page 377-386, July 2026.
Conceptual ‘Crossroads Model’ linking Leishmania, thymic infection and immune dysregulation: an integrative model is proposed in which Leishmania infection disrupts thymic architecture and stromal–thymocyte interactions. These alterations converge to promote defective tolerance, increased autoimmune risk and a microenvironment permissive to malignant ...
Alef Batista Bezerra Barros, Gabriel Augusto Leite, Arthur Gomes de Andrade, Maria Danielma dos Santos Reis, Luiz Henrique Agra Cavalcante‐Silva, Marvin Paulo Lins   +5 more
wiley   +1 more source

Ovarian hormones and high‐fat diet duration distinctively modulate hypothalamic chemokine profile

Journal of Neuroendocrinology, Volume 38, Issue 7, July 2026.
Abstract Excessive intake of saturated fats triggers inflammation in the hypothalamus, a key regulator of energy balance. In the chronic phase of this inflammatory response, bone marrow‐derived and lymphoid cells are chemoattracted to this region, partially mitigating high‐fat diet (HFD)‐induced metabolic impairments.
Alexia Guimaraes Batista Augusto, Giovanna Ariozi dos Santos, Igor Vinicius Sousa Cavalheiro, Vinicius Stefanini Mantovan, Larissa Silva Bergantini, Nicolly Porto Marin, Ester dos Santos Alves, Licio Augusto Velloso, Natalia Ferreira Mendes   +8 more
wiley   +1 more source

The Complex Relation of Branched‐Chain Amino Acids and Inflammation in the Obesity and Diabetes Context

Obesity Reviews, Volume 27, Issue 7, July 2026.
ABSTRACT In a scenario with increasing cases of obesity and diabetes worldwide, branched‐chain amino acids (BCAA) metabolism has become an important factor in the understanding of these pathologies. More recently, its chronic high plasma levels have been postulated, alongside glucose, inflammatory factors, and other molecules, as an important ...
Bernardo Starling‐Soares, Monique Macedo Coelho, Bruna Guerra Campolina, Camila Kümmel Duarte, Tatiani Uceli Maioli   +4 more
wiley   +1 more source