Results 171 to 180 of about 49,192 (255)

Senolytic Treatment With Fisetin Reverses Age‐Related Endothelial Dysfunction Partially Mediated by SASP Factor CXCL12

Aging Cell, Volume 25, Issue 5, May 2026.
Single‐cell transcriptomics identifies that oral, intermittent fisetin supplementation improves endothelial function by targeting senescent endothelial cell‐derived senescence‐associated secretory phenotype (SASP) factors and CXCL12 in old animals. The SASP and specifically CXCL12 were found to drive age‐related endothelial dysfunction by promoting ...
Sophia A. Mahoney, Krystyna Mazan‐Mamczarz, Dimitrios Tsitsipatis, Nicholas S. VanDongen, Charnae’ Henry‐Smith, Ada N. Okereke, Rachel Munk, Sanna Darvish, Kevin O. Murray, Supriyo De, Myriam Gorospe, Douglas R. Seals, Matthew J. Rossman, Allison B. Herman, Zachary S. Clayton   +14 more
wiley   +1 more source

From Development to Aging: Dynamic Roles of the Thymic Medulla in T Cell Biology

Immunological Reviews, Volume 339, Issue 1, May 2026.
ABSTRACT The thymic medulla is essential for establishing central tolerance, orchestrating the development of a diverse yet self‐tolerant T cell repertoire, and preventing autoimmunity. This process is primarily mediated through interactions between developing thymocytes and antigen‐presenting cells, including thymic epithelial cells (TECs) and ...
Christina Michalaki, Minahil Sharjeel, Jennifer E. Cowan   +2 more
wiley   +1 more source

The Secretome Derived From Serum‐Free Media of SHED‐MSCs Can Modulate THP‐1‐Derived Macrophage Cells

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Although culturing cells in serum‐free or low‐serum media may lead to reduced cell proliferation, it is crucial to minimise the presence of foreign proteins and other impurities that could compromise the validity of experimental findings on immunomodulation.
Azadeh Mohammad‐Hasani, Saeed Mohammadi, Mohsen Saeidi, Ali Fallah, Ayyoob Khosravi   +4 more
wiley   +1 more source

From Adipose Tissue to Cardiac Repair: Extracellular Vesicles in Cardiovascular Regeneration

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Adipose‐derived extracellular vesicles (ADEVs) secreted by adipose tissue have gained increasing attention due to their regenerative and immunomodulatory properties in cardiovascular diseases. They carry proteins, lipids, and nucleic acids that mediate intercellular communication and influence cardiac pathophysiology. In atherosclerosis, ADEVs
Karolina Ignaczak, Pola Ochocka, Karol Sadowski, Weronika Ploch, Dominika Tomkiel, Mariusz Tomaniak, Wioletta Olejarz   +6 more
wiley   +1 more source

Involvement of chemokine CXCL12 and its receptor CXCR4 in uterine receptivity and potential relationship to fertility in cattle: a mini review. [PDF]

Front Vet Sci
D'Occhio MJ, Campanile G, Baruselli PS.
europepmc   +1 more source

Chemokine CXC motif ligand 12 (CXCL12; SDF-1) [PDF]

Science-Business eXchange, 2014
openaire   +1 more source

Essential role of immobilized chemokine CXCL12 in the regulation of the humoral immune response. [PDF]

Proc Natl Acad Sci U S A, 2017
Barinov A, Luo L, Gasse P, Meas-Yedid V, Donnadieu E, Arenzana-Seisdedos F, Vieira P.   +6 more
europepmc   +1 more source

Modulation of Chemokine Activity for Enhanced Angiogenesis and Tissue Regeneration in Chronic Wounds. [PDF]

Int J Mol Sci
Adit GN, Srikanth K, Harithpriya K, Ganesan K, Ramkumar KM.   +4 more
europepmc   +1 more source

CXCR4 involvement in neurodegenerative diseases [PDF]

, 2018
Karch, Celeste M., Wen, Natalie
core   +1 more source

Genetic Variation in the Chemokine Network and Atherosclerosis Risk. [PDF]

Curr Atheroscler Rep
Zangas P, Georgakis MK.
europepmc   +1 more source