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Pathological roles of the homeostatic chemokine CXCL12
Cytokine and Growth Factor Reviews, 2018 CXCL12 is a CXC chemokine that traditionally has been classified as a homeostatic chemokine. It contributes to physiological processes such as embryogenesis, hematopoiesis and angiogenesis. In contrast to these homeostatic functions, increased expression
Rik Janssens +2 more
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CXCL12 / CXCR4 / CXCR7 chemokine axis and cancer progression [PDF]
Cancer and Metastasis Reviews, 2010 Chemokines, small pro-inflammatory chemoattractant cytokines that bind to specific G-protein-coupled seven-span transmembrane receptors, are major regulators of cell trafficking and adhesion. The chemokine CXCL12 (also called stromal-derived factor-1) is an important α-chemokine that binds primarily to its cognate receptor CXCR4 and thus regulates the ...
Xueqing Sun +2 more
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Allosteric modulation of the chemokine receptor-chemokine CXCR4-CXCL12 complex by tyrosine sulfation
International Journal of Biological Macromolecules, 2022The chemokine receptor CXCR4 and its cognate ligand CXCL12 mediate pathways that lead to cell migration and chemotaxis. Although the structural details of related receptor-ligand complexes have been resolved, the roles of the N-terminal domain of the receptor and post-translational sulfation that are determinants of ligand selectivity and affinity ...
Archana, Sonawani +3 more
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The roles of chemokine CXCL12 in embryonic and brain tumor angiogenesis
Seminars in Cancer Biology, 2009The formation of blood vessels in embryos and tumors are different processes but under the control of common molecular mechanisms. Chemokine CXCL12 involved in both embryonic and tumor angiogenesis. In this review, we summarize recent advances in understanding the roles of CXCL12 in brain tumor angiogenesis/vasculogenesis.
Meizhang Li, Richard M Ransohoff
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The Signaling Duo CXCL12 and CXCR4: Chemokine Fuel for Breast Cancer Tumorigenesis [PDF]
Cancers, 2020 The CXCL12/CXCR4 signaling pathway has emerged in the recent years as a key player in breast cancer tumorigenesis. This pathway controls many aspects of breast cancer development including cancer cell proliferation, motility and metastasis to all target organs.
Karolina A Zielinska +2 more
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CXCL12 chemokine and GABA neurotransmitter systems crosstalk and their putative roles [PDF]
Frontiers in Cellular Neuroscience, 2014 Since CXCL12 and its receptors, CXCR4 and CXCR7, have been found in the brain, the role of this chemokine has been expanded from chemoattractant in the immune system to neuromodulatory in the brain. Several pieces of evidence suggest that this chemokine system could crosstalk with the GABAergic system, known to be the main inhibitory neurotransmitter ...
Alice Guyon
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The multifaceted roles of the chemokines CCL2 and CXCL12 in osteophilic metastatic cancers
Cancer and Metastasis Reviews, 2021Breast and prostate cancers have a great propensity to metastasize to long bones. The development of bone metastases is life-threatening, incurable, and drastically reduces patients' quality of life. The chemokines CCL2 and CXCL12 and their respective receptors, CCR2 and CXCR4, are central instigators involved in all stages leading to cancer cell ...
Élora Midavaine +2 more
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Roles of Chemokine CXCL12 and its Receptors in Ischemic Stroke
Current Drug Targets, 2012Chemokine CXC ligand 12 (CXCL12), originally named stromal cell-derived factor-1 (SDF-1), is a member of the CXC chemokine subfamily. CXCL12 is found to be expressed by all cell types that are presented in the central nervous system (CNS). It works in conjunction with the G-protein coupled receptor CXCR4, which is found at the surface of a variety of ...
Yongting, Wang +3 more
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CXCL12 Is a constitutive and inflammatory chemokine in the intestinal immune system
Inflammatory Bowel Diseases, 2010Inflammatory bowel disease (IBD) is characterized by increased lymphocytic infiltrate to the lamina propria (LP) and upregulation of inflammatory chemokines and receptors. CXCL12 is a constitutive chemokine involved in lung, brain, and joint inflammation.
Iris, Dotan +9 more
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The chemokine CXCL12 promotes survival of postmitotic neurons by regulating Rb protein
Cell Death and Differentiation, 2008 Postmitotic neurons need to keep their cell cycle under control to survive and maintain a differentiated state. This study aims to test the hypothesis that the chemokine CXCL12 regulates neuronal survival and differentiation by promoting Rb function, as ...
Renato Brandimarti, Olimpia Meucci
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