Results 211 to 220 of about 33,556 (238)

Neuroprotective actions of the chemokine CXCL12

Chemokines are cellular mediators known for their role in immune/inflammatory responses - traditionally, yet simplistically, associated to neuronal damage. However, recent research has not only provided evidence about the beneficial nature of a controlled immune/inflammatory response in the central nervous system (CNS), but also suggested novel ...
Jaclyn Nicolai, Alessandro Fatatis, Olimpia Meucci   +2 more
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Glioblastomas: Role of CXCL12 Chemokine

2010
Chemokines are small pro-inflammatory chemoattractant cytokines that bind to specific G-protein-coupled seven-span transmembrane receptors on the plasma membrane of target cells. They are also the major regulators of cell trafficking. Chemokines and their receptors were initially associated with the trafficking of leukocytes during physiological immune
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The CXCL12–CXCR4 Chemokine Pathway: A Novel Axis Regulates Lymphangiogenesis

Clinical Cancer Research, 2012
Abstract Purpose: Lymphangiogenesis, the growth of lymphatic vessels, contributes to lymphatic metastasis. However, the precise mechanism underlying lymphangiogenesis remains poorly understood. This study aimed to examine chemokine/chemokine receptors that directly contribute to chemoattraction of activated lymphatic endothelial cells
Wei, Zhuo, Lin, Jia, Nan, Song, Xin-An, Lu, Yanping, Ding, Xiaofeng, Wang, Xiaomin, Song, Yan, Fu, Yongzhang, Luo   +8 more
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CXC chemokine ligand 12 (CXCL12) in atherosclerosis: An underlying therapeutic target

Clinica Chimica Acta, 2019
CXC chemokine ligand 12 (CXCL12) is a specific chemokine ligand and plays a significant role in cell chemotaxis. Upon binding to CXC chemokine receptor 4 (CXCR4) or CXCR7, CXCL12 can activate different signaling cascades to regulate cell proliferation, migration, and metabolism.
Jia-Hui Gao, Xiao-Hua Yu, Chao-Ke Tang   +2 more
exaly   +3 more sources

CXC chemokine ligand 12 (CXCL12) and its receptor CXCR4

Journal of Molecular Medicine, 2014
Chemokines were recognized originally for their ability to dictate the migration and activation of leukocytes. However, CXC chemokine ligand 12 (CXCL12, also known as stromal cell-derived factor-1) and its receptor CXCR4 are the first chemokine and receptor that have been shown to be critical for developmental processes, including homing and ...
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Relationships between glycosaminoglycan and receptor binding sites in chemokines—the CXCL12 example

Carbohydrate Research, 2008
Chemokines are small proteins, promoting directional migration and activation of different cells through binding to specific receptors. Most chemokines also bind to heparan sulfate (HS), a family of complex and highly sulfated glycosaminoglycan (GAG) found at the cell surface and in the extracellular matrix. This class of molecules has recently emerged
Laguri, Cédric, Arenzana-Seisdedos, Fernando, Lortat-Jacob, Hugues   +2 more
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Effects of the chemokine CXCL12 on dendritic spine dynamics

Dendritic spines are structural substrates for learning and memory and their pruning is associated with cognitive decline in conditions like Alzheimer's Disease and HIV-associated neurocognitive disorders (HAND). Our past studies in a rodent model of HAND (HIV-transgenic rat, HIV-Tg) revealed that dendritic spine loss and related cognitive deficits can
Chunta Ho, Olimpia Meucci
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[Expression and significance of chemokine CXCL12 and receptor CXCR4 in adenomyosis].

Zhonghua fu chan ke za zhi, 2020
Objective: To observe the expression, correlation and significance of chemokine (C-X-C motif) ligand 12 (CXCL12) and chemokine (C-X-C motif) receptor 4 (CXCR4) in endometrium and myometrium of adenomyosis. Methods: Totally 38 patients were selected in this study, who underwent hysterectomy for adenomyosis at Beijing Obstetrics and Gynecology Hospital ...
S, Wang, H, Duan, B H, Li, Y Y, Wang, J H, Huang, Z C, Guo   +5 more
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The role of chemokine CXCL12 in obesity induced PCa progression

2020
Prostate cancer (PCa) is the second leading cause of cancer in men, in the United States. Several studies have shown that overweight or obesity increases PCa progression and PCa mortality. However, the mechanisms underlying this association are not clear.
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The role of chemokines CXCL10 and CXCL12 in the pathogenesis of vitiligo

Zagazig University Medical Journal, 2020
Hend GadAlla, ayman youssef, khaled Gharib   +2 more
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