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Glioblastomas: Role of CXCL12 Chemokine
2010Chemokines are small pro-inflammatory chemoattractant cytokines that bind to specific G-protein-coupled seven-span transmembrane receptors on the plasma membrane of target cells. They are also the major regulators of cell trafficking. Chemokines and their receptors were initially associated with the trafficking of leukocytes during physiological immune
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Neuroprotective actions of the chemokine CXCL12
Chemokines are cellular mediators known for their role in immune/inflammatory responses - traditionally, yet simplistically, associated to neuronal damage. However, recent research has not only provided evidence about the beneficial nature of a controlled immune/inflammatory response in the central nervous system (CNS), but also suggested novel ...Jaclyn Nicolai +2 more
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[Correlations between chemokines CXCL12, CCL2, RANTES and early abortion].
Zhonghua yi xue za zhi, 2012To explore the correlations between chemokines stromal cell-derived factor-1 (CXCL12), monocyte chemotactic protein-1 (CCL2), regulated upon activation normal T cell expressed and secreted (RANTES) and early abortion.The villus and decidua tissues of recurrent spontaneous abortion group (n = 26), medical abortion group (n = 30) and normal early ...
Yu, Zhang, Yan, Gu, Jun-xia, Li, Yi, Li
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The role of chemokine CXCL12 in obesity induced PCa progression
2020Prostate cancer (PCa) is the second leading cause of cancer in men, in the United States. Several studies have shown that overweight or obesity increases PCa progression and PCa mortality. However, the mechanisms underlying this association are not clear.
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Effects of the chemokine CXCL12 on dendritic spine dynamics
Dendritic spines are structural substrates for learning and memory and their pruning is associated with cognitive decline in conditions like Alzheimer's Disease and HIV-associated neurocognitive disorders (HAND). Our past studies in a rodent model of HAND (HIV-transgenic rat, HIV-Tg) revealed that dendritic spine loss and related cognitive deficits canChunta Ho, Olimpia Meucci
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MM-124 CXCL12 Chemokine and Relationship With Multiple Myeloma
Clinical Lymphoma Myeloma and Leukemia, 2023Ekin Ece Gürer +4 more
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[Relationship between chemokine axis CXCL12-CXCR4 and epithelial ovarian cancer].
Zhonghua yi xue za zhi, 2014To explore the relationship between chemokine axis CXCL12-CXCR4 and the pathogenesis and severity of epithelial ovarian cancer.SKOV3 transfected with plasmid, SKOV3 transfected with vector and SKOV3 were cultured in vitro. Methyl thiazolyl tetrazolium (MTT) was used to analyze the effects of different concentrations of CXCL12 on the proliferation ...
Qing, Guo +5 more
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