Results 221 to 230 of about 49,192 (255)

Gene Variations of Chemokine and Chemokine Receptor CXCL12/CXCR4 in Lung Cancer

Journal of Environmental Pathology, Toxicology and Oncology, 2023
Lung cancer is the most common type of cancer in the world and about 1 million people die from lung cancer every year in the world. Inflammation is an important factor in the onset, progression and metastasis of lung cancer. The most important regulators of inflammation are chemokines and chemokine receptors.
Cansu, Ozbayer, Emine, Yagci, Guntulu, Ak, Selma, Metintas, Muzaffer, Metintas, Hulyam, Kurt   +5 more
openaire   +2 more sources

Allosteric modulation of the chemokine receptor-chemokine CXCR4-CXCL12 complex by tyrosine sulfation

International Journal of Biological Macromolecules, 2022
The chemokine receptor CXCR4 and its cognate ligand CXCL12 mediate pathways that lead to cell migration and chemotaxis. Although the structural details of related receptor-ligand complexes have been resolved, the roles of the N-terminal domain of the receptor and post-translational sulfation that are determinants of ligand selectivity and affinity ...
Archana, Sonawani, Shalmali, Kharche, Debjani, Dasgupta, Durba, Sengupta   +3 more
openaire   +2 more sources

The role of the chemokine CXCL12 in osteoclastogenesis

Trends in Endocrinology & Metabolism, 2007
The chemokine CXCL12 (variously termed stromal-derived factor 1 or B cell-stimulating factor) is a highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. CXCL12 has crucial roles in the formation of multiple organ systems during embryogenesis and in the regulation of bone marrow haematopoiesis and immune function in the ...
Gronthos, S., Zannettino, A.
openaire   +3 more sources

Roles of Chemokine CXCL12 and its Receptors in Ischemic Stroke

Current Drug Targets, 2012
Chemokine CXC ligand 12 (CXCL12), originally named stromal cell-derived factor-1 (SDF-1), is a member of the CXC chemokine subfamily. CXCL12 is found to be expressed by all cell types that are presented in the central nervous system (CNS). It works in conjunction with the G-protein coupled receptor CXCR4, which is found at the surface of a variety of ...
Yongting, Wang, Jun, Huang, Yaning, Li, Guo-Yuan, Yang   +3 more
openaire   +2 more sources

The CXCL12–CXCR4 Chemokine Pathway: A Novel Axis Regulates Lymphangiogenesis

Clinical Cancer Research, 2012
Abstract Purpose: Lymphangiogenesis, the growth of lymphatic vessels, contributes to lymphatic metastasis. However, the precise mechanism underlying lymphangiogenesis remains poorly understood. This study aimed to examine chemokine/chemokine receptors that directly contribute to chemoattraction of activated lymphatic endothelial cells
Wei, Zhuo, Lin, Jia, Nan, Song, Xin-An, Lu, Yanping, Ding, Xiaofeng, Wang, Xiaomin, Song, Yan, Fu, Yongzhang, Luo   +8 more
openaire   +2 more sources

CXC chemokine ligand 12 (CXCL12) and its receptor CXCR4

Journal of Molecular Medicine, 2014
Chemokines were recognized originally for their ability to dictate the migration and activation of leukocytes. However, CXC chemokine ligand 12 (CXCL12, also known as stromal cell-derived factor-1) and its receptor CXCR4 are the first chemokine and receptor that have been shown to be critical for developmental processes, including homing and ...
openaire   +2 more sources

Modulation of rat oligodendrocyte precursor cells by the chemokine CXCL12

NeuroReport, 2006
Migration, proliferation, and differentiation of oligodendrocyte precursor cells are essential for the assembly of myelin in the central nervous system. Knowledge on the regulation of these precursor cells is therefore of great importance for the understanding of developmental myelination and remyelination in demyelinating diseases.
Maysami, Samaneh, Nguyen, Dan, Zobel, Franziska, Pitz, Caroline, Heine, Sandra, Höpfner, Michael, Stangel, Martin   +6 more
openaire   +3 more sources

Sustained Delivery of Chemokine CXCL12 from Chemically Modified Silk Hydrogels

Biomacromolecules, 2015
A delivery platform was developed using silk-based hydrogels, and sustained delivery of the cationic chemokine CXCL12 at therapeutically relevant doses is demonstrated. Hydrogels were prepared from plain silk and silk that had been chemically modified with sulfonic acid groups. CXCL12 was mixed with the silk solution prior to gelation, resulting in 100%
Paige N, Atterberry, Travis J, Roark, Sean Y, Severt, Morgan L, Schiller, John M, Antos, Amanda R, Murphy   +5 more
openaire   +2 more sources

Chemokine CXCL12 enhances proliferation in pre‐B‐ALL via STAT5 activation

Pediatric Blood & Cancer, 2007
AbstractBackgroundCXCL12 (SDF‐1α) is a chemokine, which plays an important role in normal B‐cell lymphopoesis, migration and homing to the bone marrow (BM) and previous studies have suggested a role for CXCL12 and its receptor CXCR4 in the pathogenesis of ALL.PurposeCXCL12 levels in serum were evaluated from ALL‐children and controls.
Frida, Mowafi, Alberto, Cagigi, Ludmila, Matskova, Olle, Björk, Francesca, Chiodi, Anna, Nilsson   +5 more
openaire   +2 more sources

CXC chemokine ligand 12 (CXCL12) in atherosclerosis: An underlying therapeutic target

Clinica Chimica Acta, 2019
CXC chemokine ligand 12 (CXCL12) is a specific chemokine ligand and plays a significant role in cell chemotaxis. Upon binding to CXC chemokine receptor 4 (CXCR4) or CXCR7, CXCL12 can activate different signaling cascades to regulate cell proliferation, migration, and metabolism.
Jia-Hui, Gao, Xiao-Hua, Yu, Chao-Ke, Tang   +2 more
openaire   +2 more sources