Results 221 to 230 of about 97,684 (248)

Glioblastomas: Role of CXCL12 Chemokine

2010
Chemokines are small pro-inflammatory chemoattractant cytokines that bind to specific G-protein-coupled seven-span transmembrane receptors on the plasma membrane of target cells. They are also the major regulators of cell trafficking. Chemokines and their receptors were initially associated with the trafficking of leukocytes during physiological immune
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The CXCL12–CXCR4 Chemokine Pathway: A Novel Axis Regulates Lymphangiogenesis

Clinical Cancer Research, 2012
Abstract Purpose: Lymphangiogenesis, the growth of lymphatic vessels, contributes to lymphatic metastasis. However, the precise mechanism underlying lymphangiogenesis remains poorly understood. This study aimed to examine chemokine/chemokine receptors that directly contribute to chemoattraction of activated lymphatic endothelial cells
Wei, Zhuo, Lin, Jia, Nan, Song, Xin-An, Lu, Yanping, Ding, Xiaofeng, Wang, Xiaomin, Song, Yan, Fu, Yongzhang, Luo   +8 more
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CXC chemokine ligand 12 (CXCL12) and its receptor CXCR4

Journal of Molecular Medicine, 2014
Chemokines were recognized originally for their ability to dictate the migration and activation of leukocytes. However, CXC chemokine ligand 12 (CXCL12, also known as stromal cell-derived factor-1) and its receptor CXCR4 are the first chemokine and receptor that have been shown to be critical for developmental processes, including homing and ...
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Effects of the chemokine CXCL12 on dendritic spine dynamics

Dendritic spines are structural substrates for learning and memory and their pruning is associated with cognitive decline in conditions like Alzheimer's Disease and HIV-associated neurocognitive disorders (HAND). Our past studies in a rodent model of HAND (HIV-transgenic rat, HIV-Tg) revealed that dendritic spine loss and related cognitive deficits can
Chunta Ho, Olimpia Meucci
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[Expression and significance of chemokine CXCL12 and receptor CXCR4 in adenomyosis].

Zhonghua fu chan ke za zhi, 2020
Objective: To observe the expression, correlation and significance of chemokine (C-X-C motif) ligand 12 (CXCL12) and chemokine (C-X-C motif) receptor 4 (CXCR4) in endometrium and myometrium of adenomyosis. Methods: Totally 38 patients were selected in this study, who underwent hysterectomy for adenomyosis at Beijing Obstetrics and Gynecology Hospital ...
S, Wang, H, Duan, B H, Li, Y Y, Wang, J H, Huang, Z C, Guo   +5 more
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The role of chemokine CXCL12 in obesity induced PCa progression

2020
Prostate cancer (PCa) is the second leading cause of cancer in men, in the United States. Several studies have shown that overweight or obesity increases PCa progression and PCa mortality. However, the mechanisms underlying this association are not clear.
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The role of chemokines CXCL10 and CXCL12 in the pathogenesis of vitiligo

Zagazig University Medical Journal, 2020
Hend GadAlla, ayman youssef, khaled Gharib   +2 more
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MM-124 CXCL12 Chemokine and Relationship With Multiple Myeloma

Clinical Lymphoma Myeloma and Leukemia, 2023
Ekin Ece Gürer, Hayriye Şentürk Çiftçi, Süleyman Rüştü Oğuz, Demet Kıvanç, Sevgi Kalayoğlu Beşışık   +4 more
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[Correlations of chemokine CXCL12 and its receptor to tumor metastasis].

Ai zheng = Aizheng = Chinese journal of cancer, 2009
Previous studies suggest that chemokine CXCL12 and its receptor CXCR4 play important roles in embryonic development, stem cell trafficking, and inflammatory reactions. It is a central factor in directing cell movement of many physiologic and pathologic processes.
Yu-Ping, Jiang, Xiao-Hua, Wu
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Tamoxifen as a modulator of CXCL12-CXCR4-CXCR7 chemokine axis: A breast cancer and glioblastoma view

Cytokine, 2023
Thaynan Lopes Gonçalves, Valeria Pereira Ferrer   +1 more
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