Results 81 to 90 of about 279,214 (183)
Cross-talk between chronic lymphocytic leukemia (CLL) tumor B cells and mesenchymal stromal cells (MSCs): implications for neoplastic cell survival [PDF]
, 2015 Leukemic cells from Chronic Lymphocytic Leukemia (CLL) patients interact with stromal cells of the surrounding microenvironment. Mesenchymal Stromal Cells (MSCs) represent the main population in CLL marrow stroma, which may play a key role for disease ...
Ave, Elisa +15 more
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BiomoleculesChemokines are cytokines with chemoattractant capacities that exert their physiological functions through the binding of chemokine receptors. Thus, chemokine and receptor complexes exert important roles in regulating development and homeostasis during ...
Zhi-Shuai Hou +12 more
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The Role of Chemokines in Breast Cancer Pathology and Its Possible Use as Therapeutic Targets
Journal of Immunology Research, 2014 Chemokines are small proteins that primarily regulate the traffic of leukocytes under homeostatic conditions and during specific immune responses. The chemokine-chemokine receptor system comprises almost 50 chemokines and approximately 20 chemokine ...
M. Isabel Palacios-Arreola +5 more
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Evaluation of the effect of GM-CSF blocking on the phenotype and function of human monocytes [PDF]
, 2020 Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a multipotent cytokine that prompts the proliferation of bone marrow-derived macrophages and granulocytes.
Esmaeil, Nafiseh +3 more
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Wnt5a causes ROR1 to complex and activate cortactin to enhance migration of chronic lymphocytic leukemia cells. [PDF]
, 2019 Chronic lymphocytic leukemia cells (CLL) migrate between the blood and lymphoid tissues in response to chemokines. Such migration requires structured cytoskeletal-actin polymerization, which may involve the protein cortactin. We discovered that treatment
Hasan, Md Kamrul +4 more
core +1 more source
Biased and G protein-independent signaling of chemokine receptors
Frontiers in Immunology, 2014 Biased signaling or functional selectivity occurs when a 7TM receptor preferentially activates one of several available pathways. It can be divided into three distinct forms: ligand bias, receptor bias, and tissue or cell bias, where it is mediated by ...
Anne eSteen +3 more
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Chemokine receptor specific antibodies in cancer immunotherapy: achievements and challenges
Frontiers in Immunology, 2015 The 1990s brought a burst of information regarding the structure, expression pattern, and role in leukocyte migration and adhesion of chemokines and their receptors. At that time, the FDA approved the first therapeutic antibodies for cancer treatment.
Maria eVela +4 more
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Journal of Inflammation Research, 2020 Sarah Dhaiban, Mena Al-Ani, Noha Mousaad Elemam, Azzam A Maghazachi College of Medicine and Immuno-Oncology Group, Sharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab EmiratesCorrespondence: Azzam A MaghazachiDepartment of
Dhaiban S +3 more
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The role of chemokines in acute liver injury
Frontiers in Physiology, 2012 Chemokines are small molecular weight proteins primarily known to drive migration of immune cells populations. In both acute and chronic liver injury, hepatic chemokine expression is induced resulting in inflammatory cell infiltration, angiogenesis, and ...
Yedidya eSaiman, Scott L. Friedman
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Structural biology of chemokine receptors
Biological Research, 1999 Chemokine receptors are G protein-coupled receptors that mediate migration and activation of leukocytes as an important part of a protective immune response to injury and infection.
DANIEL ROJO +2 more
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