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A guide to chemokines and their receptors [PDF]
The FEBS Journal, 2018 The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that signal through cell surface G‐protein coupled heptahelical chemokine receptors.
Braun A +11 more
core +2 more sources
BiomoleculesCell migration capacity represents an essential function of the immune system. Pregnancy involves numerous morphogenetic events, angiogenesis, the establishment of intercellular connections, and complex interactions between maternal and fetal immune ...
Julia A. Shevchenko +2 more
doaj +2 more sources
Inflammatory Chemokines in Atherosclerosis
Cells, 2021 Atherosclerosis is a long-term, chronic inflammatory disease of the vessel wall leading to the formation of occlusive or rupture-prone lesions in large arteries. Complications of atherosclerosis can become severe and lead to cardiovascular diseases (CVD)
Selin Gencer +4 more
doaj +2 more sources
Chemokines and chemokine receptors: A new strategy for breast cancer therapy
Cancer Medicine, 2020 Chemokines and chemokine receptors not only participate in the development of tissue differentiation, hematopoiesis, inflammation, and immune regulation but also play an important role in the process of tumor development.
Hui Liu +8 more
doaj +2 more sources
Chemokines Modulate Immune Surveillance in Tumorigenesis, Metastasis, and Response to Immunotherapy
Frontiers in Immunology, 2019 Chemokines are small secreted proteins that orchestrate migration and positioning of immune cells within the tissues. Chemokines are essential for the function of the immune system.
Anna E. Vilgelm +3 more
doaj +2 more sources
Chemokines as key mediators in RIPI: pathophysiology and translational potential [PDF]
Frontiers in ImmunologyRadiation-induced pulmonary injury (RIPI) is a common adverse effect following thoracic radiotherapy (RT), and immune-related responses play a pivotal role in the pathogenesis of RIPI.
Ling Zhao +20 more
doaj +2 more sources
Cytokines and chemokines in Mycobacterium tuberculosis infection [PDF]
Microbiology spectrum, 2016 Cooper, Andrea +3 more
core +3 more sources
Cellular & Molecular Immunology, 2023 Chemokines are an indispensable component of our immune system through the regulation of directional migration and activation of leukocytes. CXCL8 is the most potent human neutrophil-attracting chemokine and plays crucial roles in the response to ...
S. Cambier, M. Gouwy, P. Proost
semanticscholar +1 more source
Cells, 2021 Although G protein-coupled receptor kinases (GRKs) have long been known to regulate G protein-coupled receptor (GPCR) desensitization, their more recently characterized functions as scaffolds and signalling adapters underscore that this small family of ...
Marta Laganà +2 more
doaj +1 more source
Key chemokines direct migration of immune cells in solid tumors
Cancer Gene Therapy, 2021 Immune cell infiltration into solid tumors, their movement within the tumor microenvironment (TME), and interaction with other immune cells are controlled by their directed migration towards gradients of chemokines.
Karan Kohli +2 more
semanticscholar +1 more source