Results 21 to 30 of about 18,475 (201)

Identification of Therapeutic Targets and Prognostic Biomarkers Among CXC Chemokines in the Renal Cell Carcinoma Microenvironment

Frontiers in Oncology, 2020
Background: Renal cell carcinoma (RCC) is one of the most common malignances with an ever-increasing incidence and high mortality. Cross-talk between cancer cells and interstitial cells exerts significant effects on neoplasia and tumor development and is
Qingquan Zeng, Shuolei Sun, Yaxian Li, Xiaoling Li, Zuwei Li, Hao Liang   +5 more
doaj   +1 more source

CXC Chemokines as Therapeutic Targets and Prognostic Biomarkers in Skin Cutaneous Melanoma Microenvironment

Frontiers in Oncology, 2021
BackgroundSkin Cutaneous Melanoma (SKCM) is a tumor of the epidermal melanocytes induced by gene activation or mutation. It is the result of the interaction between genetic, constitutional, and environmental factors.
Xuezhi Zhou, Manjuan Peng, Ye He, Jingjie Peng, Xuan Zhang, Chao Wang, Xiaobo Xia, Weitao Song   +7 more
doaj   +1 more source

Production of CXC and CC chemokines by human antigen-presenting cells in response to Lassa virus or closely related immunogenic viruses, and in cynomolgus monkeys with lassa fever. [PDF]

PLoS Neglected Tropical Diseases, 2014
The pathogenesis of Lassa fever (LF), a hemorrhagic fever endemic to West Africa, remains unclear. We previously compared Lassa virus (LASV) with its genetically close, but nonpathogenic homolog Mopeia virus (MOPV) and demonstrated that the strong ...
Delphine Pannetier, Stéphanie Reynard, Marion Russier, Xavier Carnec, Sylvain Baize   +4 more
doaj   +1 more source

CXC chemokines in angiogenesis

Journal of Leukocyte Biology, 2000
Abstract A variety of factors have been identified that regulate angiogenesis, including the CXC chemokine family. The CXC chemokines are a unique family of cytokines for their ability to behave in a disparate manner in the regulation of angiogenesis.
Belperio, John A., Keane, Michael P., Arenberg, Douglas A., Addison, Christina L., Ehlert, Jan E., Burdick, Marie D., Strieter, Robert M.   +6 more
openaire   +3 more sources

Discovery and pharmacophoric characterization of chemokine network inhibitors using phage-display, saturation mutagenesis and computational modelling

Nature Communications, 2023
CC and CXC-chemokines are the primary drivers of chemotaxis in inflammation, but chemokine network redundancy thwarts pharmacological intervention. Tick evasins promiscuously bind CC and CXC-chemokines, overcoming redundancy.
Serena Vales, Jhanna Kryukova, Soumyanetra Chandra, Gintare Smagurauskaite, Megan Payne, Charlie J. Clark, Katrin Hafner, Philomena Mburu, Stepan Denisov, Graham Davies, Carlos Outeiral, Charlotte M. Deane, Garrett M. Morris, Shoumo Bhattacharya   +13 more
doaj   +1 more source

CXC Chemokines in the Pathogenesis of Pulmonary Disease and Pharmacological Relevance

International Journal of Inflammation, 2022
Chemokines and their receptors play important roles in the pathophysiology of many diseases by regulating the cellular migration of major inflammatory and immune players.
Kayode Komolafe, Maricica Pacurari
doaj   +1 more source

The Role of CXC Chemokines in Cancer Progression

Cancers, 2022
CXC chemokines are small chemotactic and secreted cytokines. Studies have shown that CXC chemokines are dysregulated in multiple types of cancer and are closely correlated with tumor progression. The CXC chemokine family has a dual function in tumor development, either tumor-promoting or tumor-suppressive depending on the context of cellular signaling.
Tiantian Wu, Wannian Yang, Aiqin Sun, Zhixiao Wei, Qiong Lin   +4 more
openaire   +2 more sources

CC and CXC chemokines play key roles in the development of polyomaviruses related pathological conditions

Virology Journal, 2021
It has been reported that polyomaviruses are the microbes which can be a cause of several human pathological conditions including cancers, nephropathy, progressive multifocal leukoencephalopathy and gynaecological disease. Although investigators proposed
Mohammad Hassan Mohammadi, Ashraf Kariminik   +1 more
doaj   +1 more source

Cloning and bioactivity analysis of a CXC ligand in black seabream Acanthopagrus schlegeli: the evolutionary clues of ELR⁺CXC chemokines

BMC Immunology, 2008
Background The ELR+CXC chemokines are multifunctional mediators that are mainly responsible for the recruitment of leucocytes to sites of inflammation and infection.
Kezhi Xing, Yong Zhang, Chunpin Gao, Zhonghua Cai, Yaou Zhang   +4 more
doaj   +1 more source

Targeting Rac1 signaling inhibits streptococcal M1 protein-induced CXC chemokine formation, neutrophil infiltration and lung injury. [PDF]

PLoS ONE, 2013
Infections with Streptococcus pyogenes exhibit a wide spectrum of infections ranging from mild pharyngitis to severe Streptococcal toxic shock syndrome (STSS). The M1 serotype of Streptococcus pyogenes is most commonly associated with STSS.
Songen Zhang, Milladur Rahman, Su Zhang, Lei Song, Heiko Herwald, Henrik Thorlacius   +5 more
doaj   +1 more source