Results 51 to 60 of about 68,540 (230)

Overexpression of the duffy antigen receptor for chemokines (DARC) by NSCLC tumor cells results in increased tumor necrosis

BMC Cancer, 2004
Background The Duffy antigen receptor for chemokines (DARC) is known to be a promiscuous chemokine receptor that binds a variety of CXC and CC chemokines in the absence of any detectable signal transduction events.
Burdick Marie D, Belperio John A, Addison Christina L, Strieter Robert M   +3 more
doaj   +1 more source

Prognostic Significance and Therapeutic Target of CXC Chemokines in the Microenvironment of Lung Adenocarcinoma

International Journal of General Medicine, 2022
Kun Wang, Rongyang Li, Yu Zhang, Weifeng Qi, Tao Fang, Weiming Yue, Hui Tian Department of Thoracic Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, People’s Republic of ChinaCorrespondence: Hui Tian ...
Wang K, Li R, Zhang Y, Qi W, Fang T, Yue W, Tian H   +6 more
doaj  

Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets [PDF]

, 2018
Both CC and CXC-class chemokines drive inflammatory disease. Tick salivary chemokine-binding proteins (CKBPs), or evasins, specifically bind subsets of CC- or CXC-chemokines, and could precisely target disease-relevant chemokines. Here we have used yeast
Philip Elders, Yara Alenazi, James R. O. Eaton, Shoumo Bhattacharya, Akane Kawamura, Kamayani Singh, Graham Davies   +6 more
core   +3 more sources

TRIM proteins and CXS chemokines : evolutionary dynamics and functional characterization of two large protein families in teleost fish [PDF]

, 2012
Two large protein families with roles in the immune system were the subject of this thesis. In part one of the thesis, TRIM proteins were studied, which are part of an ancient intracellular immune system. In mammals, TRIM proteins were recently found to
Aa, L.M., van der
core  

The Novel Purification and Biophysical Characterization of CXC Chemokines [PDF]

, 2022
The chemokines are small, signaling proteins responsible for leukocyte recruitment through concentration gradient driven responses for inflammatory diseases such as tissue damage or sun burn, tumor suppression and regulation, and obesity from insulin ...
Martin, Patrick
core  

Targeting CXCR2 in Nociceptive Sensory Neurons Offers Novel Therapeutic Potentials for Postoperative Pain

Advanced Science, EarlyView.
Tissue incision induces CXCL5 release, which activates neuronal CXCR2 on incision‐innervating sensory neurons. Neuronal CXCR2 couples with TRPA1 to drive mechanical pain and engages p38 MAPK signaling to upregulate TRPV1 and promote heat pain. Targeted Cxcr2 knockdown relieves incisional pain while preserving CXCR2‐dependent neutrophil responses ...
Yushuang Pan, Peiyi Li, Yufeng Chen, Zishan Dong, Yuanyuan Li, Boyu Liu, Yan Tai, Chuan Wang, Jianqiao Fang, Chengyu Yin, Boyi Liu   +10 more
wiley   +1 more source

Chemokines and immunity

Einstein (São Paulo)
Chemokines are a large family of small cytokines and generally have low molecular weight ranging from 7 to 15kDa. Chemokines and their receptors are able to control the migration and residence of all immune cells.
Diana Carolina Torres Palomino, Luciana Cavalheiro Marti   +1 more
doaj   +1 more source

A comprehensive bioinformatics analysis to identify potential prognostic biomarkers among CC and CXC chemokines in breast cancer

Scientific Reports, 2022
Breast cancer (BC) is a major human health problem due to its increasing incidence and mortality rate. CC and CXC chemokines are associated with tumorigenesis and the progression of many cancers.
Hossein Hozhabri, Marziyeh Mazaheri Moghaddam, Madiheh Mazaheri Moghaddam, Ali Mohammadian   +3 more
doaj   +1 more source

Interleukin-6-Production Is Responsible for Induction of Hepatic Synthesis of Several Chemokines as Acute-Phase Mediators in Two Animal Models: Possible Significance for Interpretation of Laboratory Changes in Severely Ill Patients

Biology, 2022
A mild to moderate increase in acute-phase proteins (APPs) and a decrease in serum albumin levels are detected in hospitalized COVID-19 patients. A similar trend is also observed for acute-phase cytokines (APC), mainly IL6, besides chemokines (e.g ...
Ihtzaz Ahmed Malik, Giuliano Ramadori
doaj   +1 more source

The expression and role of CXC chemokines in colorectal cancer

, 2011
<p>Cancer is a life-threatening disease world-wide and colorectal cancer is the second common cause of cancer mortality. The interaction between tumor cells and stromal cells plays a crucial role in tumor initiation and progression and is partially
G. Laureys, Struyf, Sofie, Sofie Struyf, Jo Van Damme, Laureys, Genevieve, Geneviève Laureys, Van Damme, Jozef, J. Van Damme, Hannelien Verbeke, S. Struyf, Van Damme, Jo, Verbeke, Hannelien, H. Verbeke   +12 more
core   +1 more source