Results 31 to 40 of about 68,540 (230)

Human Chemokines as Antimicrobial Peptides with Direct Parasiticidal Effect on Leishmania mexicana In Vitro [PDF]

, 2013
Chemokines and chemokine receptor-mediated effects are important mediators of the immunological response and cure in human leishmaniasis. However, in addition to their signalling properties for leukocytes, many chemokines have also been shown to act ...
Paul Bates (134046), Shannon, Oonagh, Sara K Söbirk, Arne Egesten, Mattias Collin (62685), Egesten, Arne, Arne Egesten (365606), Oonagh Shannon (194608), Matthias Mörgelin, Mörgelin, Matthias, Sara K. Söbirk (393666), Mattias Collin, Collin, Mattias, Bates, Paul, Matthias Mörgelin (109607), Oonagh Shannon, Karlsson Söbirk, Sara, Paul Bates, Karlsson Söbirk, Sara,, Mörgelin, Matthias,, Egesten, Arne,, Shannon, Oonagh,, Collin, Mattias,, Lund University., Söbirk, Sara K   +24 more
core   +4 more sources

Identification of Therapeutic Targets and Prognostic Biomarkers Among CXC Chemokines in the Renal Cell Carcinoma Microenvironment

Frontiers in Oncology, 2020
Background: Renal cell carcinoma (RCC) is one of the most common malignances with an ever-increasing incidence and high mortality. Cross-talk between cancer cells and interstitial cells exerts significant effects on neoplasia and tumor development and is
Qingquan Zeng, Shuolei Sun, Yaxian Li, Xiaoling Li, Zuwei Li, Hao Liang   +5 more
doaj   +1 more source

CXC Chemokines as Therapeutic Targets and Prognostic Biomarkers in Skin Cutaneous Melanoma Microenvironment

Frontiers in Oncology, 2021
BackgroundSkin Cutaneous Melanoma (SKCM) is a tumor of the epidermal melanocytes induced by gene activation or mutation. It is the result of the interaction between genetic, constitutional, and environmental factors.
Xuezhi Zhou, Manjuan Peng, Ye He, Jingjie Peng, Xuan Zhang, Chao Wang, Xiaobo Xia, Weitao Song   +7 more
doaj   +1 more source

Production of CXC and CC chemokines by human antigen-presenting cells in response to Lassa virus or closely related immunogenic viruses, and in cynomolgus monkeys with lassa fever. [PDF]

PLoS Neglected Tropical Diseases, 2014
The pathogenesis of Lassa fever (LF), a hemorrhagic fever endemic to West Africa, remains unclear. We previously compared Lassa virus (LASV) with its genetically close, but nonpathogenic homolog Mopeia virus (MOPV) and demonstrated that the strong ...
Delphine Pannetier, Stéphanie Reynard, Marion Russier, Xavier Carnec, Sylvain Baize   +4 more
doaj   +1 more source

CXC chemokines in angiogenesis

Journal of Leukocyte Biology, 2000
Abstract A variety of factors have been identified that regulate angiogenesis, including the CXC chemokine family. The CXC chemokines are a unique family of cytokines for their ability to behave in a disparate manner in the regulation of angiogenesis.
Belperio, John A., Keane, Michael P., Arenberg, Douglas A., Addison, Christina L., Ehlert, Jan E., Burdick, Marie D., Strieter, Robert M.   +6 more
openaire   +3 more sources

CXC Chemokine/Receptor Axis Profile and Metastasis in Prostate Cancer

Frontiers in Molecular Biosciences, 2020
In this study, the effects of the CXC chemokine/receptor axis on lymph node and distant metastases of prostate cancer (PC) were analyzed. Further, mRNA expression data of metastatic PC were extracted from the Stand Up To Cancer–Prostate Cancer Foundation
Naoya Nagaya, Naoya Nagaya, Geun Taek Lee, Shigeo Horie, Isaac Yi Kim   +4 more
doaj   +1 more source

Discovery and pharmacophoric characterization of chemokine network inhibitors using phage-display, saturation mutagenesis and computational modelling

Nature Communications, 2023
CC and CXC-chemokines are the primary drivers of chemotaxis in inflammation, but chemokine network redundancy thwarts pharmacological intervention. Tick evasins promiscuously bind CC and CXC-chemokines, overcoming redundancy.
Serena Vales, Jhanna Kryukova, Soumyanetra Chandra, Gintare Smagurauskaite, Megan Payne, Charlie J. Clark, Katrin Hafner, Philomena Mburu, Stepan Denisov, Graham Davies, Carlos Outeiral, Charlotte M. Deane, Garrett M. Morris, Shoumo Bhattacharya   +13 more
doaj   +1 more source

Expression of CXCL10 is associated with response to radiotherapy and overall survival in squamous cell carcinoma of the tongue [PDF]

, 2014
Five-year survival for patients with oral cancer has been disappointingly stable during the last decades, creating a demand for new biomarkers and treatment targets.
Philip John Coates, Torben Wilms, Laurell, Göran,, Rentoft, Matilda,, Coates, Philip John, Matilda Rentoft, Lotta Loljung, Göran Laurell, Karin Nylander, Rentoft, Matilda, Laurell, Göran, Wilms, Torben, Loljung, Lotta, Nylander, Karin, Loljung, Lotta,, Wilms, Torben,, Nylander, Karin,, Coates, Philip John,   +17 more
core   +1 more source

The role of CXC chemokines in the transition of chronic inflammation to esophageal and gastric cancer [PDF]

, 2012
<p>Chronic inflammation may increase the risk to develop cancer, for instance esophagitis or gastritis may lead to development of esophageal or gastric cancer, respectively.
S. Struyf, Geboes, Karel, Struyf, Sofie, Van Damme, Jo, H. Verbeke, K. Geboes, Verbeke, Hannelien, J. Van Damme   +7 more
core   +1 more source

CC and CXC chemokines play key roles in the development of polyomaviruses related pathological conditions

Virology Journal, 2021
It has been reported that polyomaviruses are the microbes which can be a cause of several human pathological conditions including cancers, nephropathy, progressive multifocal leukoencephalopathy and gynaecological disease. Although investigators proposed
Mohammad Hassan Mohammadi, Ashraf Kariminik   +1 more
doaj   +1 more source