The Chemokines CXC, CC and C in the Pathogenesis of COVID-19 Disease and as Surrogates of Vaccine-Induced Innate and Adaptive Protective Responses [PDF]
Vaccines, 2022 COVID-19 is one of the progressive viral pandemics that originated from East Asia. COVID-19 or SARS-CoV-2 has been shown to be associated with a chain of physio-pathological mechanisms that are basically immunological in nature.
Mojgan Noroozi Karimabad +9 more
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The Role of CXC Chemokines in Cancer Progression
Cancers, 2022 CXC chemokines are small chemotactic and secreted cytokines. Studies have shown that CXC chemokines are dysregulated in multiple types of cancer and are closely correlated with tumor progression. The CXC chemokine family has a dual function in tumor development, either tumor-promoting or tumor-suppressive depending on the context of cellular signaling.
Tiantian Wu +4 more
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CXC Chemokines in the Pathogenesis of Pulmonary Disease and Pharmacological Relevance
International Journal of Inflammation, 2022 Chemokines and their receptors play important roles in the pathophysiology of many diseases by regulating the cellular migration of major inflammatory and immune players.
Kayode Komolafe, Maricica Pacurari
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Regulation of Expression of CXC Chemokines in Cultured Hepatocytes [PDF]
Iranian Journal of Public Health, 2005 Chemokines are low molecular weight proteins (8-17 kDa). They are classified in four distinct groups as CXC, CC, CX3C and C. Depending on the presence or absence of a motif called ELR (Arg-Leu-Glu) before the first cysteine residue in their structure ...
GhH Hassanshahiraviz, AJ Dickson
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High-affinity ELR+ CXC chemokines display balanced G protein-, GRK- and β-arrestin-associated transducer engagement at the viral G protein-coupled receptor ORF74 [PDF]
Frontiers in PharmacologyOpen reading frame 74 (ORF74) is the single G protein-coupled receptor (GPCR) encoded in the genome of Kaposi’s sarcoma-associated herpesvirus (KSHV). Due to its high constitutive activity and broad chemokine binding profile, ORF74 contributes to KSHV ...
Qianqian Kong +4 more
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The Role of CXC Chemokines in Cardiovascular Diseases
Frontiers in Pharmacology, 2022 Cardiovascular disease (CVD) is a class of diseases with high disability and mortality rates. In the elderly population, the incidence of cardiovascular disease is increasing annually.
Xiyi Lu +12 more
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Epigenetics underpinning the regulation of the CXC (ELR+) chemokines in non-small cell lung cancer. [PDF]
PLoS ONE, 2011 BACKGROUND:Angiogenesis may play a role in the pathogenesis of Non-Small Cell Lung cancer (NSCLC). The CXC (ELR(+)) chemokine family are powerful promoters of the angiogenic response.
Anne-Marie Baird +2 more
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Cellular & Molecular Biology LettersReproductive cancers are malignancies that develop in the reproductive organs. One of the leading cancers affecting the male reproductive system on a global scale is prostate cancer (PCa). The negative consequences of PCa metastases endure and are severe,
Amin Ullah, Wang Jiao, Bairong Shen
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Interferon-inducible CXC chemokines directly contribute to host defense against inhalational anthrax in a murine model of infection. [PDF]
PLoS Pathogens, 2010 Chemokines have been found to exert direct, defensin-like antimicrobial activity in vitro, suggesting that, in addition to orchestrating cellular accumulation and activation, chemokines may contribute directly to the innate host response against ...
Matthew A Crawford +7 more
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Identification of Potential Therapeutic Targets Among CXC Chemokines in Breast Tumor Microenvironment Using Integrative Bioinformatics Analysis [PDF]
Cellular Physiology and Biochemistry, 2018 Background/Aims: Breast cancer is a common cause of cancer mortality throughout the world. The cross-talk between cancer cells and interstitial cells exerts significant effects on neoplasia and tumor development and is modulated in part by chemokines ...
Erbao Chen +9 more
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