Results 11 to 20 of about 597,477 (331)

Microbiota, a key player in alcoholic liver disease [PDF]

Clinical and Molecular Hepatology, 2018
Alcoholic liver disease (ALD) is a major cause of morbidity and mortality worldwide. Only 20% of heavy alcohol consumers develop alcoholic liver cirrhosis.
Anne-Marie Cassard, Dragos Ciocan
doaj   +1 more source

Cytokines and Chemokines Involved in Osteoarthritis Pathogenesis

International Journal of Molecular Sciences, 2021
Osteoarthritis is a common cause of disability worldwide. Although commonly referred to as a disease of the joint cartilage, osteoarthritis affects all joint tissues equally.
Vilim Molnar, V. Matišić, Ivan Kodvanj, Roko Bjelica, Željko Jeleč, D. Hudetz, Eduard Rod, F. Čukelj, Trpimir Vrdoljak, D. Vidović, M. Starešinić, S. Sabalić, Borut Dobričić, Tadija Petrović, D. Antičević, I. Borić, R. Košir, Uršula Prosenc Zmrzljak, D. Primorac   +18 more
semanticscholar   +1 more source

Specific microbiome profile in Takayasu’s arteritis and giant cell arteritis

Scientific Reports, 2021
Recent studies have provided evidence of a close link between specific microbiota and inflammatory disorders. While the vessel wall microbiota has been recently described in large vessel vasculitis (LVV) and controls, the blood microbiome in these ...
Anne Claire Desbois, Dragos Ciocan, David Saadoun, Gabriel Perlemuter, Patrice Cacoub   +4 more
doaj   +1 more source

The Effect of Hypoxia on the Expression of CXC Chemokines and CXC Chemokine Receptors—A Review of Literature

International Journal of Molecular Sciences, 2021
Hypoxia is an integral component of the tumor microenvironment. Either as chronic or cycling hypoxia, it exerts a similar effect on cancer processes by activating hypoxia-inducible factor-1 (HIF-1) and nuclear factor (NF-κB), with cycling hypoxia showing
J. Korbecki, K. Kojder, Patrycja Kapczuk, P. Kupnicka, B. Gawrońska-Szklarz, I. Gutowska, D. Chlubek, I. Baranowska-Bosiacka   +7 more
semanticscholar   +1 more source

Efficient Plasma Cell Differentiation and Trafficking Require Cxcr4 Desensitization

Cell Reports, 2016
CXCR4 plays a central role in B cell immune response, notably by promoting plasma cell (PC) migration and maintenance in the bone marrow (BM). Gain-of-function mutations in CXCR4 affecting receptor desensitization have been reported in the rare ...
Vincent Biajoux, Jessica Natt, Christelle Freitas, Nagham Alouche, Antoine Sacquin, Patrice Hemon, Françoise Gaudin, Nicolas Fazilleau, Marion Espéli, Karl Balabanian   +9 more
doaj   +1 more source

Functional diversity of chemokines and chemokine receptors in response to viral infection of the central nervous system. [PDF]

, 2006
Encounters with neurotropic viruses result in varied outcomes ranging from encephalitis, paralytic poliomyelitis or other serious consequences to relatively benign infection.
A. Meyer, A.A. Dandekar, A.D. Luster, B. Mehrad, B. Parra, B. Parra, B.D. Pearce, B.P. Chen, B.T. Fife, C. Gerard, C. Ramakrishna, C. Ramakrishna, C.A. Biron, C.E. Patterson, C.J. Raport, C.M. Hogaboam, D. Franciotta, D. Galimberti, D. Whiting, D.D. Taub, D.J. Mahad, D.M. Muller, D.N. Cook, D.P. Widney, E. Lazzeri, E.J. McMahon, F.R. Fischer, F.S. Cheever, G. Penna, G. Penna, G.B. Huffnagle, G.C. Hildebrandt, G.F. Wu, H. Bartosik-Psujek, H.G. Fischer, H.G. Fischer, I. Banisor, I. Clark-Lewis, I. Salomon, I. Tsunoda, I.E. Flesch, J. Gosling, J.B. Domachowske, J.C. Houck, J.F. Bazan, J.H. Dufour, J.H. Xie, J.J. Phillips, J.M. Farber, J.S. Haring, J.S. Haring, J.S. Williamson, J.S. Williamson, K. Holmes, K. McIntosh, K.E. Balashov, K.S. Held, K.S. Warmington, K.V. Holmes, L. Boring, L. Boring, L. Cartier, L. Gu, L. Gu, L. Pewe, L. Pewe, M. Baggiolini, M. Greter, M. Matsui, M.A. Olszewski, M.J. Buchmeier, M.J. Trifilo, M.J. Trifilo, M.J. Trifilo, M.M. Lai, M.T. Lin, M.T. Lin, M.T. Liu, M.T. Liu, M.T. Liu, N. Sato, N.J. Megjugorac, N.W. Marten, R. Gade-Andavolu, R. Watanabe, R.F. Castro, R.S. Klein, S. Narumi, S. Qin, S. Xue, S.A. Stohlman, S.A. Stohlman, S.D. Miller, S.M. Stamatovic, S.R. Perlman, T.E. Lane, T.E. Lane, T.E. Lane, T.L. Sorensen, T.L. Sorensen, T.S. Kim, T.S. Kim, W.G. Glass, W.G. Glass, W.G. Glass, W.G. Glass, W.J. Karpus, Y. Zhang, Y. Zhou   +108 more
core   +1 more source

Questions about Chemokine and Chemokine Receptor Antagonism in Renal Inflammation [PDF]

, 2010
Chemokines remain attractive therapeutic targets for modulating inflammatory diseases in all areas of medicine including acute and chronic kidney disease.
Anders, Hans-Joachim, Sayyed, Sufyan Ali, Vielhauer, Volker   +2 more
core   +1 more source

CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of the Ligands of Receptors CCR1, CCR2, CCR3, and CCR4

International Journal of Molecular Sciences, 2020
CC chemokines, a subfamily of 27 chemotactic cytokines, are a component of intercellular communication, which is crucial for the functioning of the tumor microenvironment.
J. Korbecki, K. Kojder, Donata Simińska, R. Bohatyrewicz, I. Gutowska, D. Chlubek, I. Baranowska-Bosiacka   +6 more
semanticscholar   +1 more source

A broad G protein-coupled receptor internalization assay that combines SNAP-tag labeling, diffusion-enhanced resonance energy transfer, and a highly emissive terbium cryptate acceptor

Frontiers in Endocrinology, 2015
Although G protein-coupled receptor (GPCR) internalization has long been considered a major aspect of the desensitization process that tunes ligand responsiveness, internalization is also involved in receptor resensitization and signaling, as well as the
Angélique eLEVOYE, Angélique eLEVOYE, Jurriaan M. eZWIER, Agnieszka eJARACZ-ROS, Laurence eKLIPFEL, Martin eCOTTET, Martin eCOTTET, Damien eMAUREL, Damien eMAUREL, Sara eBDIOUI, Karl eBALABANIAN, Laurent ePREZEAU, Laurent ePREZEAU, Eric eTRINQUET, Thierry eDURROUX, Thierry eDURROUX, Françoise eBACHELERIE   +16 more
doaj   +1 more source

Identifying chemokines as therapeutic targets in renal disease: Lessons from antagonist studies and knockout mice [PDF]

, 2004
Chemokines, in concert with cytokines and adhesion molecules, play multiple roles in local and systemic immune responses. In the kidney, the temporal and spatial expression of chemokines correlates with local renal damage and accumulation of chemokine ...
Abdi R, Anders HJ, Anders HJ, Anders HJ, Bruhl H, Burne-Taney MJ, Feng L, Fituri O, Fujinaka H, Garcia GE, Grone HJ, Keane MP, Mack M, Miura M, Murphy PM, Nath KA, Perez de Lema G, Rollins BJ, Romagnani P, Segerer S, Segerer S, Segerer S, Tang WW, Taub DD, Tesch GH, Tokuda A, Topham PS, Vielhauer V, Vielhauer V, Wada T, Wang Y, Wenzel U, Wu X, Wu X, Zernecke A   +34 more
core   +1 more source