Antioxidants, 2023 Chemoresistance remains the foremost challenge in cancer therapy. Targeting reactive oxygen species (ROS) manipulation is a promising strategy in cancer treatment since tumor cells present high levels of intracellular ROS, which makes them more ...
Huan Wang +5 more
doaj +2 more sources
The Mechanism of Warburg Effect-Induced Chemoresistance in Cancer
Frontiers in Oncology, 2021 Although chemotherapy can improve the overall survival and prognosis of cancer patients, chemoresistance remains an obstacle due to the diversity, heterogeneity, and adaptability to environmental alters in clinic.
Chang Liu, Ying Jin, Zhimin Fan
doaj +2 more sources
Warburg effect and lactylation in cancer: mechanisms for chemoresistance [PDF]
Molecular MedicineIn the clinical management of cancers, the emergence of chemoresistance represents a profound and imperative “pain point” that requires immediate attention. Understanding the mechanisms of chemoresistance is essential for developing effective therapeutic
Wenjie Zhang +6 more
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Chemoresistance acquisition induces a global shift of expression of aniogenesis-associated genes and increased pro-angogenic activity in neuroblastoma cells [PDF]
, 2009 BACKGROUND: Chemoresistance acquisition may influence cancer cell biology. Here, bioinformatics analysis of gene expression data was used to identify chemoresistance-associated changes in neuroblastoma biology.
Barth, Susanne +10 more
core +8 more sources
Exosome-transmitted LUCAT1 promotes stemness transformation and chemoresistance in bladder cancer by binding to IGF2BP2 [PDF]
Journal of Experimental & Clinical Cancer ResearchThe chemotherapy resistance is an awkward challenge in management of bladder cancer (BC). Cancer organoid model is an effective preclinical tumor model that could faithfully represent clinical manifestations and simulate the biological processes of ...
Yonghao Zhan +6 more
doaj +2 more sources
Single-cell multi-omics elucidates the role of RPS27-RPS24 fusion gene in osteosarcoma chemoresistance and metabolic regulation [PDF]
Cell Death DiscoveryOsteosarcoma (OS) presents significant treatment challenges due to chemoresistance. This study explores the molecular mechanisms underlying chemoresistance in OS, focusing on the novel fusion gene RPS27-RPS24. Using single-cell multi-omics techniques, we
Zhiwei Tao +5 more
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Histone lactylation enhances GCLC expression and thus promotes chemoresistance of colorectal cancer stem cells through inhibiting ferroptosis [PDF]
Cell Death and DiseaseColorectal cancer stem cells (CCSCs) play a critical role in mediating chemoresistance. Lactylation is a post-translational modification induced by lactate that regulates gene expression.
Jiao Deng +8 more
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METTL3 promotes chemoresistance in small cell lung cancer by inducing mitophagy
Journal of experimental & clinical cancer research : CR, 2023 Background Small cell lung cancer (SCLC) is the most aggressive subtype of lung cancer. Although most patients are initially sensitive to first-line combination chemotherapy with cisplatin and etoposide, chemotherapy drug resistance easily develops and ...
Yueqin Sun +7 more
semanticscholar +1 more source
NAT10 drives cisplatin chemoresistance by enhancing ac4C-associated DNA repair in bladder cancer.
Cancer Research, 2023 Epitranscriptomic RNA modifications constitute a critical gene regulatory component that can affect cancer progression. Among these, the RNA N4-acetylcytidine (ac4C) modification, which is mediated by the ac4C writer N-acetyltransferase 10 (NAT10 ...
Ruihui Xie +12 more
semanticscholar +1 more source
Disease Models & Mechanisms, 2021 Extramedullary multiple myeloma (EMM) has an overall survival of 6 months and occurs in 20% of multiple myeloma (MM) patients. Genetic and epigenetic mechanisms involved in EMM and the therapeutic role of new agents for MM are not well established ...
Lourdes Farre +15 more
doaj +1 more source