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KLF4 in cancer chemoresistance: molecular mechanisms and therapeutic implications [PDF]
Discover OncologyChemoresistance is a major obstacle in cancer treatment, and it often results in treatment failure and disease progression. Among the plethora of factors contributing to chemoresistance, the transcription factor Krüppel-like factor 4 (KLF4) has emerged ...
Suresh Singh Yadav +6 more
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USP29 and SMURF1 orchestrate FSP1-mediated ferroptosis suppression to facilitate chemoresistance in gastric cancer [PDF]
Nature CommunicationsGastric cancer (GC) ranks as the third leading cause of cancer-related mortality. Chemoresistance poses a major obstacle to successful treatment for GC patients. Here, we demonstrate that ferroptosis suppressor protein 1 (FSP1) enables chemoresistance in
Zheming Wu +8 more
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Mechanisms of Resistance to Chemotherapy in Hypopharyngeal Carcinoma [PDF]
BiomedicinesHypopharyngeal carcinoma (HPC) represents the most prognostically unfavorable subtype among head and neck malignancies. Platinum-based neoadjuvant chemotherapy serves as a critical therapeutic approach for improving outcomes in hypopharyngeal carcinoma ...
Zhaoyue Lu +3 more
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miR-200c sensitizes breast cancer cells to doxorubicin treatment by decreasing TrkB and Bmi1 expression. [PDF]
, 2012 Acquired resistance to classical chemotherapeutics is a major obstacle in cancer treatment. Doxorubicin is frequently used in breast cancer therapy either as single-agent or in combination with other drugs like docetaxel and cyclophosphamide.
Kopp, Florian +3 more
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Disease Models & Mechanisms, 2021 Extramedullary multiple myeloma (EMM) has an overall survival of 6 months and occurs in 20% of multiple myeloma (MM) patients. Genetic and epigenetic mechanisms involved in EMM and the therapeutic role of new agents for MM are not well established ...
Lourdes Farre +15 more
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The Mechanism of Warburg Effect-Induced Chemoresistance in Cancer
Frontiers in Oncology, 2021 Although chemotherapy can improve the overall survival and prognosis of cancer patients, chemoresistance remains an obstacle due to the diversity, heterogeneity, and adaptability to environmental alters in clinic.
Chang Liu, Ying Jin, Zhimin Fan
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The MicroRNA-Based Strategies to Combat Cancer Chemoresistance via Regulating Autophagy
Frontiers in Oncology, 2022 Chemoresistance frequently occurs in cancer treatment, which results in chemotherapy failure and is one of the most leading causes of cancer-related death worldwide.
Yuhe Lei +5 more
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Clinical and Translational Medicine, 2022 Background Although chemotherapy, the most widely used systemic treatment in triple‐negative breast cancer (TNBC), markedly improved the patients’ outcome, chemoresistance always occurs.
Zhenchong Xiong +7 more
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Antioxidants, 2023 Chemoresistance remains the foremost challenge in cancer therapy. Targeting reactive oxygen species (ROS) manipulation is a promising strategy in cancer treatment since tumor cells present high levels of intracellular ROS, which makes them more ...
Huan Wang +5 more
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AKAP8L enhances the stemness and chemoresistance of gastric cancer cells by stabilizing SCD1 mRNA
Cell Death and Disease, 2022 Gastric cancer (GC) remains the third leading cause of cancer-related deaths. Chemoresistance is the major determinant of GC treatment failure. To explore the molecular mechanisms of GC chemoresistance, mass spectrometry was performed to detect the genes
Ruihong Zhang +10 more
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