Results 141 to 150 of about 64,721 (205)

Atypical MAPKs in cancer

The FEBS Journal, EarlyView.
Mitogen‐activated protein kinases (MAPKs) regulate various cellular processes, including proliferation, differentiation, and motility. Alterations in these signalling pathways can lead to various diseases, including cancer. The atypical MAPKs ERK3 (MAPK6), ERK4 (MAPK4), ERK7/8 (MAPK15) and NLK have long been neglected in kinomic studies.
Katrin Dahm, Parthiban Vijayarangakannan, Hans‐Peter Wollscheid, Hansjörg Schild, Krishnaraj Rajalingam   +4 more
wiley   +1 more source

WBP1 regulates mitochondrial function and ferroptosis to modulate chemoresistance in colorectal cancer. [PDF]

Mol Med
Wang Y, Qi D, Ge G, Cao N, Liu X, Zhu N, Li F, Huang X, Yu K, Zheng J, Wang D, Yao W, Chen L, Dong Z.   +13 more
europepmc   +1 more source

Extracellular vesicles in multiple myeloma: pathogenesis and therapeutic application

The FEBS Journal, EarlyView.
Multiple myeloma is characterised by the clonal proliferation of plasma cells in the bone marrow. Extracellular vesicles (EVs) are a key component of cell‐to‐cell communication within the bone marrow microenvironment, promoting tumour growth, bone remodelling, immune modulation, angiogenesis and therapeutic resistance.
Chloe Wylie, Rebecca Rowan, Dessi Malinova, Lisa Crawford   +3 more
wiley   +1 more source

Extracellular vesicle-mediated chemoresistance in breast cancer: focus on miRNA cargo. [PDF]

Extracell Vesicles Circ Nucl Acids
Ciferri MC, Tasso R.
europepmc   +1 more source

ZNF224 enhances the oncogenic function of p21 via p53 and AKT pathways in melanoma

The FEBS Journal, EarlyView.
KRAB zinc finger protein ZNF224 acts as an oncogenic factor in melanoma cells, enhancing p21 cytosolic retention and impairing nuclear p21 cytostatic activity through stimulation of the AKT pathway. Furthermore, ZNF224 regulates transcriptional expression levels of p21 via p53.
Leandra Sepe, Umberto Candia, Dario Sasso del Verme, Elvira Toscano, Marianna Toriello, Gaetano Sodaro, Roberta Rapuano, Simona Romano, Michela Grosso, Giovanni Paolella, Angelo Lupo, Paola Costanzo, Elena Cesaro   +12 more
wiley   +1 more source

TMEM160 inhibits KEAP1 to suppress ferroptosis and induce chemoresistance in gastric cancer. [PDF]

Cell Death Dis
Huang C, Zeng Q, Chen J, Wen Q, Jin W, Dai X, Ruan R, Zhong H, Xia Y, Wu Z, Huang R, Zhang J, Yao Y, Li L, Lei W, Xiong J, Deng J.   +16 more
europepmc   +1 more source

Prognostic value of clinical parameters and exosomal lncRNA NEAT1_1 in MEN1‐related non‐functioning pancreatic neuroendocrine tumors

Journal of Neuroendocrinology, EarlyView.
Abstract Non‐functioning pancreatic neuroendocrine tumors (NF‐pNETs) significantly contribute to the premature death of multiple endocrine neoplasia type 1 (MEN1) patients. Reliable prognostic markers are not yet available. MicroRNAs (miRNA) and long‐non‐coding (lnc) RNAs, transported by extracellular vesicles, are emerging as new prognostic tools ...
Jerena Manoharan, Max Albers, Natalia Khizanishvili, Norman Krasser‐Gercke, Maxime Schmitt, Ioannis Mintziras, Sabine Wächter, Anja Rinke, Yutong Gao, Jörg W. Bartsch, Moritz Jesinghaus, Pietro Di Fazio, Detlef K. Bartsch   +12 more
wiley   +1 more source

IGF2BP1-HAX-1 positive feedback loop-mediated HAX-1 overexpression blocks autophagic flux and promotes chemoresistance in nasopharyngeal carcinoma. [PDF]

Cell Mol Life Sci
Zhang S, Gu M, Yin H, Pan S, Xie H, Chen W, Gul S, Zhao Y, Wang Z, Zheng W, You Y, You B.   +11 more
europepmc   +1 more source

Bufalin targets the SRC-3/c-Myc pathway in chemoresistant cells to regulate metastasis induced by chemoresistance in colorectal cancer. [PDF]

J Cancer Res Clin Oncol
Chen J, Wu C, Yu K, Liu J, Yang J, Li W, Tang X, Shi Y, Xu K, Chen Y, Qin X.   +10 more
europepmc   +1 more source

Non‐Anticoagulant Heparin: An In Vitro Investigation of a Novel Therapeutic Approach for Oral Cancer

Oral Diseases, EarlyView.
ABSTRACT Background Oral squamous cell carcinoma (OSCC) represents a significant global oral health concern. Non‐anticoagulant heparin (NH) emerges as a promising solution considering the enhanced survival observed with anticoagulants in cancer treatment. Methods We used the MTS assay (0/24/48/72 h), scratch assay (MuviCyte, 0–18 h), invasion Matrigel (
S. A. Hamza, R. Paolini, N. M. O'Brien‐Simpson, W. Singleton, R. Patini, M. McCullough, A. Celentano   +6 more
wiley   +1 more source