Results 141 to 150 of about 133,761 (337)

The Role of the Tumor Microenvironment in CSC Enrichment and Chemoresistance: 3D Co-culture Methods [PDF]

, 2021
Michael E. Bregenzer, Eric N. Horst, Pooja Mehta, Catherine S. Snyder, Taylor Repetto, Geeta Mehta   +5 more
openalex   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Supplementary Figure 3 from SMAD4 Loss in Colorectal Cancer Patients Correlates with Recurrence, Loss of Immune Infiltrate, and Chemoresistance [PDF]

, 2023
Isaac Wasserman, Lik Hang Lee, Shuji Ogino, Michael R. Marco, Chao Wu, Xi Chen, Jashodeep Datta, Eran Sadot, Bryan Szeglin, José G. Guillem, Philip B. Paty, Martin R. Weiser, Garrett M. Nash, Leonard B. Saltz, Afşar Barlas, Katia Manova‐Todorova, Srijaya Prakash Babu Uppada, Arthur E. Elghouayel, Peter Ntiamoah, Jonathan N. Glickman, Tsuyoshi Hamada, Keisuke Kosumi, Kentaro Inamura, Andrew T. Chan, Reiko Nishihara, Andrea Cercek, Karuna Ganesh, Nancy E. Kemeny, Punita Dhawan, Rona Yaeger, Charles L. Sawyers, Julio García‐Aguilar, Marios Giannakis, Jinru Shia, J. Joshua Smith   +34 more
openalex   +2 more sources

Author Correction: Butein promotes ubiquitination-mediated survivin degradation inhibits tumor growth and overcomes chemoresistance [PDF]

, 2023
Xinyong Dong, Wenbin Liu, M Kellis, Yu Gan, Zhou Li, Wěi Li, Xie Li   +6 more
openalex   +1 more source

The “stem” of chemoresistance [PDF]

Cell Cycle, 2010
Giulia, Bertolini, Laura, Gatti, Luca, Roz   +2 more
openaire   +2 more sources

A Modular DNAzyme for Precise Visualization and Intervention of Alternative Splicing Isoforms in Live Cells

Advanced Science, EarlyView.
A Stringent dUPlex‐activated Error Robust (SUPER) DNAzyme system enables real‐time imaging of alternative mRNA splicing (e.g., Bcl‐xL/Bcl‐xS) in living cells via target‐triggered split‐DNAzyme reassembly and dual‐color fluorescence. It also achieves mRNA‐selective knockdown through DNAzyme‐based gene regulation, serving as a versatile tool for splicing
Mengru Lin, Jiale Sun, Yuqing Mao, Yuhao Tang, Fuan Wang, Zhihong Liu, Jing Wang   +6 more
wiley   +1 more source

Machine Learning‐Enhanced Analysis of Exosomal Surface Sialic Acid Using Surface‐Enhanced Raman Spectroscopy for Ovarian Cancer Diagnosis and Therapeutic Monitoring

Advanced Science, EarlyView.
Machine learning‐assisted surface‐enhanced Raman spectroscopy analysis of exosomal sialic acid for ovarian cancer diagnosis, as well as independent monitoring of exosomal sialic acid expression levels across different treatment periods, reveals a potential correlation with treatment response.
Lili Cong, Jiaqi Wang, Sijun Huang, Xiaxia Man, Yi Guo, Shuping Xu, Songling Zhang   +6 more
wiley   +1 more source

Mechanical Stimuli‐Induced Manipulation of Malignant Behavior in Bioprinted Cancer Microtissues via PI3K/NF‐κB Activation

Advanced Science, EarlyView.
A mechanically tunable ECM platform is created by integrating dECM–alginate matrices with in‐bath tumor printing. The mechanically tunable ECM environment drives tumors to acquire hypoxia, mechanotransduction signaling, metastatic traits, and drug‐resistant phenotypes that collectively promote malignant transformation.
Seok‐Hyeon Lee, Jeongho Lee, Min‐Seo Choi, Minjun Ahn, Sik Yoon, Dongjun Lee, Sae‐Ock Oh, Won‐Woo Cho, Byoung Soo Kim   +8 more
wiley   +1 more source

Activation of the PD-1/PD-L1 immune checkpoint confers tumor cell chemoresistance associated with increased metastasis [PDF]

, 2016
Madison Black, Ivraym B. Barsoum, Peter Truesdell, Tiziana Cotechini, Shannyn K. Macdonald-Goodfellow, Margaret G. Petroff, D. Robert Siemens, Madhuri Koti, Andrew W. Craig, Charles H. Graham   +9 more
openalex   +1 more source

Hypoxia Dictates Metabolic Rewiring of Tumors: Implications for Chemoresistance [PDF]

, 2020
Dimas Carolina Belisario, Joanna Kopecka, M. Pasino, Muhlis Akman, Enrico De Smaele, Massimo Donadelli, Chiara Riganti   +6 more
openalex   +1 more source