Warburg effect and lactylation in cancer: mechanisms for chemoresistance [PDF]
Molecular MedicineIn the clinical management of cancers, the emergence of chemoresistance represents a profound and imperative “pain point” that requires immediate attention. Understanding the mechanisms of chemoresistance is essential for developing effective therapeutic
Wenjie Zhang +6 more
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Exosome-transmitted LUCAT1 promotes stemness transformation and chemoresistance in bladder cancer by binding to IGF2BP2 [PDF]
Journal of Experimental & Clinical Cancer ResearchThe chemotherapy resistance is an awkward challenge in management of bladder cancer (BC). Cancer organoid model is an effective preclinical tumor model that could faithfully represent clinical manifestations and simulate the biological processes of ...
Yonghao Zhan +6 more
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Histone lactylation enhances GCLC expression and thus promotes chemoresistance of colorectal cancer stem cells through inhibiting ferroptosis [PDF]
Cell Death and DiseaseColorectal cancer stem cells (CCSCs) play a critical role in mediating chemoresistance. Lactylation is a post-translational modification induced by lactate that regulates gene expression.
Jiao Deng +8 more
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Single-cell multi-omics elucidates the role of RPS27-RPS24 fusion gene in osteosarcoma chemoresistance and metabolic regulation [PDF]
Cell Death DiscoveryOsteosarcoma (OS) presents significant treatment challenges due to chemoresistance. This study explores the molecular mechanisms underlying chemoresistance in OS, focusing on the novel fusion gene RPS27-RPS24. Using single-cell multi-omics techniques, we
Zhiwei Tao +5 more
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HSF1 at the crossroads of chemoresistance: from current insights to future horizons in cell death mechanisms [PDF]
Frontiers in Cell and Developmental BiologyHeat Shock Factor 1 (HSF1) is a major transcriptional factor regulating the heat shock response and has become a potential target for overcoming cancer chemoresistance. This review comprehensively examines HSF1’s role in chemoresistance and its potential
Shruti Ghai, Rejina Shrestha, Kuo-Hui Su
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Frontiers in Pharmacology, 2021 Chemoresistance has become a prevalent phenomenon in cancer therapy, which alleviates the effect of chemotherapy and makes it difficult to break the bottleneck of the survival rate of tumor patients.
Jin-Feng Xu +9 more
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Exploring role of 5hmC as potential marker of chemoresistance
Molecular & Cellular Oncology, 2020 Chemoresistance remains to be a common and significant hurdle with all chemotherapies. Tumors gain resistance by acquiring additional mutations. Some of the chemoresistance mechanisms are known and can be tackled. However, the majority of chemoresistance
Suhas S. Kharat, Shyam K. Sharan
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Bcl-2 inhibits apoptosis by increasing the time-to-death and intrinsic cell-to-cell variations in the mitochondrial pathway of cell death [PDF]
Apoptosis (2010), 2010 BH3 mimetics have been proposed as new anticancer therapeutics. They target anti-apoptotic Bcl-2 proteins, up-regulation of which has been implicated in the resistance of many cancer cells, particularly leukemia and lymphoma cells, to apoptosis. Using probabilistic computational modeling of the mitochondrial pathway of apoptosis, verified by single ...
arxiv +1 more source
Understanding AKT-mediated chemoresistance: the relationship between ion channels and AKT activation [PDF]
arXiv, 2023 Overcoming chemoresistance is a challenge for multiple chemotherapeutics agents like cisplatin. ABC transporters such as MDR1 or MRPs and PI3K/AKT pathway have been proposed as actors of chemoresistance in several cancers. In this review we describe two downstream targets of Akt: c-myc and p53 in the chemoresistance. We suggest a potential link between
arxiv
MicroRNA‐433‐3p enhances chemosensitivity of glioma to cisplatin by downregulating NR5A2
Brain and Behavior, Volume 12, Issue 12, December 2022., 2022 miR‐433‐3p mediated the ability of NR5A2 to regulate the malignant behavior of glioma cells Abstract Objective We attempted to investigate influence of microRNA‐433‐3p on malignant progression of glioma and identify its molecular mechanism, thus laying groundwork for glioma management.
Jun Li +9 more
wiley +1 more source