Results 11 to 20 of about 149,400 (379)
Chemoresistance in Pancreatic Cancer [PDF]
International Journal of Molecular Sciences, 2019 Pancreatic ductal adenocarcinoma (PDAC), generally known as pancreatic cancer (PC), ranks the fourth leading cause of cancer-related deaths in the western world.
Siyuan Zeng +5 more
semanticscholar +4 more sources
Controlling secretion to limit chemoresistance [PDF]
Genes & Development, 2016 The tumor microenvironment influences cancer progression and therapy outcome by mechanisms not yet fully understood. In this issue, Bent et al. (2016) show how chemotherapy causes endothelial senescence.
Georgilis, A, Gil, J
core +7 more sources
Clusterin and Chemoresistance [PDF]
, 2009 Resistance to anticancer agents is one of the primary impediments to effective cancer therapy. Chemoresistance occurs not only to clinically established therapeutic agents but also to novel targeted therapeutics. Both intrinsic and acquired mechanisms have been implicated in drug resistance but it remains controversial which mechanisms are responsible ...
Julie Y. Djeu, Sheng Wei
openalex +4 more sources
The molecular mechanisms of chemoresistance in cancers
Oncotarget, 2017 Overcoming intrinsic and acquired drug resistance is a major challenge in treating cancer patients because chemoresistance causes recurrence, cancer dissemination and death. This review summarizes numerous molecular aspects of multi-resistance, including
Hua-Chuan Zheng
semanticscholar +4 more sources
Chemosensitivity and Chemoresistance Testing [PDF]
Journal of Clinical Oncology, 2005 Maurie Markman
openalex +3 more sources
Cancer Research, 2023 Cancer stem-like cells (CSCs) play pivotal roles in both chemoresistance and recurrence of many cancer types, including urothelial bladder cancer (UBC). In addition to intrinsic signaling pathways, extracellular cues from the tumor microenvironment (TME)
J. Zhuang +11 more
semanticscholar +1 more source
The MicroRNA-Based Strategies to Combat Cancer Chemoresistance via Regulating Autophagy
Frontiers in Oncology, 2022 Chemoresistance frequently occurs in cancer treatment, which results in chemotherapy failure and is one of the most leading causes of cancer-related death worldwide.
Yuhe Lei +5 more
doaj +1 more source
Novel strategies to reverse chemoresistance in colorectal cancer
Cancer Medicine, 2023 Colorectal cancer (CRC) is a common gastrointestinal malignancy with high morbidity and fatality. Chemotherapy, as traditional therapy for CRC, has exerted well antitumor effect and greatly improved the survival of CRC patients.
Shu-Chang Ma +7 more
semanticscholar +1 more source
Advancement of science, 2022 Obesity is closely related to a poor prognosis in patients with advanced colorectal cancer (CRC), but the mechanisms remain unclear. Ferroptosis is a form of nonapoptotic cell death characterized by lipid reactive oxygen species (ROS) accumulation and ...
Qiumo Zhang +11 more
semanticscholar +1 more source
Clinical and Translational Medicine, 2022 Background Although chemotherapy, the most widely used systemic treatment in triple‐negative breast cancer (TNBC), markedly improved the patients’ outcome, chemoresistance always occurs.
Zhenchong Xiong +7 more
doaj +1 more source