Results 241 to 250 of about 133,761 (337)

Lipid balance and chemoresistance in cancer cells. [PDF]

Elife
Kanemaru K, Nakamura Y.
europepmc   +1 more source

A11 Peptide Enhances Radiosensitivity by Degrading EphA2 in Nasopharyngeal Carcinoma

Cancer Science, EarlyView.
In EphA2‐high‐expressing nasopharyngeal carcinoma cells, radiation triggers RSK‐dependent phosphorylation of EphA2 at Ser897, which in turn activates AKT and promote radioresistance. The A11 peptide breaks this signaling cascade by degrading EphA2 and blocking its S897 phosphorylation, thereby markedly enhancing radiosensitivity.
Ming Zhang, Zhi‐Qiang Xiao, Wei Huang, Shan‐Shan Lu, Hong Yi, Juan Feng   +5 more
wiley   +1 more source

Evaluation of Circulating Tumor DNA as a Biomarker for Chemoresistance in Colorectal Cancer.

J Pharm Bioallied Sci
Lakshmi KR, Sankaranarayanan CS, Gogineni RAS, Shaheen KA, Peddi P.   +4 more
europepmc   +1 more source

Inflammatory cytokine-associated cisplatin resistance in non-small cell lung cancer and re-sensitization through interleukin-6 receptor blockade. [PDF]

World J Clin Oncol
Calibasi-Kocal G.
europepmc   +1 more source

FB23‐2 and Cisplatin Synergize to Inhibit Head and Neck Squamous Cell Carcinoma by Targeting the XPF/ERCC1 Complex

Cancer Science, EarlyView.
FB23‐2 potentiates cisplatin's antitumor efficacy in head and neck squamous cell carcinoma by disrupting XPF/ERCC1 complex assembly and nuclear translocation, thereby suppressing DNA damage repair machinery and amplifying platinum‐induced tumor cell death.
Yaoqi Jiang, Hongshi Cai, Yue Zhu, Jianfeng Liang, Hongyu Li, Fan Song, Ziyi Wang, Jinsong Hou   +7 more
wiley   +1 more source

Mechanistic roles of long non-coding RNAs in gastric cancer therapy resistance. [PDF]

Noncoding RNA Res
Chen J, Gao J.
europepmc   +1 more source

IAP Antagonists Selectively Eliminate Therapy‐Induced Senescent Cancer Cells via TNFα‐Independent Apoptosis

Cancer Science, EarlyView.
Upon chemotherapy, a subset of cancer cells enters a senescent state, referred to as TIS. When IAP antagonists are administered, TIS cells are selectively eliminated through TNFα‐independent apoptosis. TNFα secreted by TIS cancer cells may also act in a paracrine manner to enhance extrinsic apoptosis in neighboring non‐senescent cancer cells.
Hiroaki Ochiiwa, Takeshi Wakasa, Yuki Kataoka, Koji Ando, Eiji Oki, Yoshihiko Maehara, Makoto Iimori, Hiroyuki Kitao   +7 more
wiley   +1 more source

Does microtubule motor-mediated centrosomal dyshomeostasis confer chemoresistance in breast cancer? [PDF]

J Mammary Gland Biol Neoplasia
Priyanga J, Guha G, Bhakta-Guha D.
europepmc   +1 more source

Reversal of MPPa‐PDT Resistance in Osteosarcoma by Targeting ROCK2‐Mediated Autophagy

Cell Proliferation, EarlyView.
ROCK2 competes with MST1 to bind to the aa 28‐198 region of SAV1 and then regulates the Hippo pathway to affect autophagy, resulting in the resistance of OS to MPPa‐PDT. Targeted inhibition of ROCK2 by screening for J059‐0149 increases the sensitivity of osteosarcoma to MPPa‐PDT. ABSTRACT Osteosarcoma (OS) is a primary bone tumour that occurs mostly in
Xuan Yi, Xueqiang Deng, Jianyong Deng, Chen Li, Hong Peng, Yunyan Du, Qing Li, Xiaohua Yan, Xin Hu, Yan Zheng, Shenliang Chen, Ting Xiong, Debin Xu, Leifeng Chen, Liang Hao   +14 more
wiley   +1 more source

Glutamine metabolism drives tumor aggressiveness but not chemoresistance in ovarian carcinoma cell lines. [PDF]

Transl Cancer Res
Hélage S, Blanc-Quintin MC, Neveux N, Ginguay A, De Bandt JP, Cynober L, Alexandre J, Goldwasser F, Dion É.   +8 more
europepmc   +1 more source