Results 21 to 30 of about 64,721 (205)
Involvement of calcium channels Orai3 in the chemoresistance to cisplatin in non-small cell lung cancer (NSCLC) [PDF]
arXiv, 2023 This is the second part of the previous review. In the previous review we suspected that Orai3 channels were involved in lung cancer and more precisely in several cancers. Here we confirm that calcium dysregulation is important for cancer development. in this paper we show that Orai3 is an upstream activator of AKT and we prove that AKT is involved in ...
arxiv
Pulsed laser deposition of ZnO thin films decorated with Au and Pd nanoparticles with enhanced acetone sensing performance [PDF]
Applied Physics A 123, 262 (2017), 2017 We fabricate and compare nanocomposite thin-film ZnO chemoresistive acetone sensors with gold or palladium nanoparticles on the surface, at low operating temperatures. The sensors are fabricated by pulsed laser deposition and operate in the temperature range 159-200oC.
arxiv +1 more source
Lipid metabolism in pancreatic cancer: emerging roles and potential targets
Cancer Communications, Volume 42, Issue 12, Page 1234-1256, December 2022., 2022 Abstract Pancreatic cancer is one of the most serious health issues in developed and developing countries, with a 5‐year overall survival rate currently <9%. Patients typically present with advanced disease due to vague symptoms or lack of screening for early cancer detection.
Xinpeng Yin +6 more
wiley +1 more source
p53 Signaling on Microenvironment and Its Contribution to Tissue Chemoresistance
Membranes, 2022 Chemoresistance persists as a significant, unresolved clinical challenge in many cancer types. The tumor microenvironment, in which cancer cells reside and interact with non-cancer cells and tissue structures, has a known role in promoting every aspect ...
Leonel Cardozo de Menezes e Souza +4 more
doaj +1 more source
Cancer Medicine, Volume 11, Issue 24, Page 5079-5096, December 2022., 2022 Necroptosis is a newly discovered form of cell necrosis that plays a vital role in cancer development. We identified a necroptosis‐related gene signature based on the TCGA cohort, which was validated externally in the ICGC‐LIRI‐JP and GSE14520 cohorts.
Junliang Chen +5 more
wiley +1 more source
The Emerging Role of Exosomes in Cancer Chemoresistance
Frontiers in Cell and Developmental Biology, 2021 Chemoresistance is an impending challenge in cancer treatment. In recent years, exosomes, a subtype of extracellular vesicles with a diameter of 40–150 nm in bloodstream and other bio-fluids, have attracted increasing interest. Exosomes contain proteins,
Jing Li +8 more
doaj +1 more source
Exosomes and their roles in the chemoresistance of pancreatic cancer
Cancer Medicine, Volume 11, Issue 24, Page 4979-4988, December 2022., 2022 Despite the development of multiple promising chemotherapeutic agents as recommended first‐line treatment for PC, the therapeutic efficacy is largely limited by unwanted drug resistance.Exploring the relation between exosomes and chemoresistance may be conducive to understanding molecular mechanisms and taking effective measures to reduce the ...
Yubin Pan +4 more
wiley +1 more source
Journal of Ovarian Research, 2022 Background Studies have revealed the implications of cancer-associated fibroblasts (CAFs) in tumor progression, metastasis, and treatment resistance.
Li Han +5 more
doaj +1 more source
A Computational Model of YAP/TAZ Mechanosensing [PDF]
Biophysical Journal, 110(11), 2540-2550 (2016), 2016 In cell proliferation, stem cell differentiation, chemoresistance and tissue organization, the ubiquitous role of YAP/TAZ continues to impact our fundamental understanding in numerous physiological and disease systems. YAP/TAZ is an important signaling nexus integrating diverse mechanical and biochemical signals, such as ECM stiffness, adhesion ligand ...
arxiv +1 more source
Molecular and cellular paradigms of multidrug resistance in cancer
Cancer Reports, Volume 5, Issue 12, December 2022., 2022 Abstract Background The acquisition of resistance to chemotherapy is a major hurdle in the successful application of cancer therapy. Several anticancer approaches, including chemotherapies, radiotherapy, surgery and targeted therapies are being employed for the treatment of cancer.
Foram U. Vaidya +6 more
wiley +1 more source