Results 21 to 30 of about 149,400 (379)
Extracellular vesicles in ovarian cancer chemoresistance, metastasis, and immune evasion
Cell Death and Disease, 2022 Chemoresistance and metastasis are the major challenges for the current ovarian cancer treatment. Understanding the mechanisms of ovarian cancer progression and metastasis is critically important for developing novel therapies.
W. Tian +7 more
semanticscholar +1 more source
miR-200c sensitizes breast cancer cells to doxorubicin treatment by decreasing TrkB and Bmi1 expression. [PDF]
, 2012 Acquired resistance to classical chemotherapeutics is a major obstacle in cancer treatment. Doxorubicin is frequently used in breast cancer therapy either as single-agent or in combination with other drugs like docetaxel and cyclophosphamide.
Kopp, Florian +3 more
core +6 more sources
Cell Death and Disease, 2022 Cellular senescence is characterized by a tumor-suppressive program as well as a pro-inflammatory secretome. Neutrophils constitute significant compositions of malignancies and play key roles in tumor development.
Baochi Ou +6 more
semanticscholar +1 more source
Clinical and Translational Medicine, 2022 Background Chemoresistance to cisplatin (DDP) remains a major challenge in advanced gastric cancer (GC) treatment. Although accumulating evidence suggests an association between dysregulation of long non‐coding RNAs (lncRNAs) and chemoresistance, the ...
Yiran Zhu +10 more
semanticscholar +1 more source
Mitochondrial determinants of chemoresistance [PDF]
Cancer Drug Resistance, 2019 Chemoresistance constitute nowadays the major contributor to therapy failure in most cancers. There are main factors that mitigate cell response to therapy, such as target organ, inherent sensitivity to the administered compound, its metabolism, drug efflux and influx or alterations on specific cellular targets, among others. We now know that intrinsic
Patricia Sancho, Ansooya Bokil
openaire +3 more sources
YTHDF1 promotes breast cancer cell growth, DNA damage repair and chemoresistance
Cell Death and Disease, 2022 Chemoresistance represents a major obstacle to the treatment of human cancers. Increased DNA repair capacity is one of the important mechanisms underlying chemoresistance.
Yu Sun +5 more
semanticscholar +1 more source
Molecular Oncology, 2020 Malignant tumors, including colorectal cancer (CRC), usually rely on ATP generation through aerobic glycolysis for both rapid growth and chemotherapy resistance.
Xinyi Wang +12 more
semanticscholar +1 more source
Battling Chemoresistance in Cancer: Root Causes and Strategies to Uproot Them
International Journal of Molecular Sciences, 2021 With nearly 10 million deaths, cancer is the leading cause of mortality worldwide. Along with major key parameters that control cancer treatment management, such as diagnosis, resistance to the classical and new chemotherapeutic reagents continues to be ...
A. Ramos +2 more
semanticscholar +1 more source
Cells, 2020 The JAK/STAT3 signaling pathway plays an essential role in various types of cancers. Activation of this pathway leads to increased tumorigenic and metastatic ability, the transition of cancer stem cells (CSCs), and chemoresistance in cancer via enhancing
W. Jin
semanticscholar +1 more source
Journal of Extracellular Vesicles, 2023 Ovarian cancer (OvCa) is the gynaecological disorder with the poorest prognosis due to the fast development of chemoresistance. We sought to connect chemoresistance and cancer cell‐derived extracellular vesicles (EV).
Gerrit Hugendieck +16 more
doaj +1 more source