Results 301 to 310 of about 149,400 (379)

TGF‐β Enhances Doxorubicin Resistance and Anchorage‐Independent Growth in Cancer Cells by Inducing ALDH1A1 Expression

Cancer Science, EarlyView.
We have demonstrated that prestimulation of human lung cancer cells with TGF‐β enhances resistance to doxorubicin‐induced growth inhibition, depending on Smad3 and Smad4 through induction of ALDH1A1. Knockdown of ALDH1A1 suppressed TGF‐β‐induced resistance to doxorubicin, and exogenous expression of ALDH1A1 in SMAD3‐KO cells restored the drug ...
Takashi Yokoyama, Masao Saitoh, Keiji Miyazawa   +2 more
wiley   +1 more source

Engineered EVs‐Mediated miR‐222 Targeting PTEN/FN1 Axis Reverses Anthracycline Resistance in HER2‐Negative Breast Cancer

Cancer Science, EarlyView.
We revealed the pivotal role of EVs‐mediated miR‐222 inhibition in modulating adriamycin resistance through post‐transcriptional regulation. Through the systematic implementation of Engineered EVs containing targeted miRNA mimics and inhibitors, we successfully delineated the specific contribution of EVs‐derived miR‐222 to drug resistance phenotypes in
Sujin Yang, Mei Yang, Quanfeng Shao, Dandan Wang, Shanliang Zhong, Suyu Yang, Haiyan Gao, Xihu Qin, Weixian Chen   +8 more
wiley   +1 more source

Revisiting Treatment Strategies: Addressing Epithelial-to-Mesenchymal Transition-Induced Resistance in Hepatocellular Carcinoma. [PDF]

BME Front
Naserkhaki R, Shokouhian B, Tahamtani Y, Khosravi A, Iravani S, Zarrabi A, Vosough M.   +6 more
europepmc   +1 more source

SHBs Mitigates Sorafenib‐Induced Apoptosis in Hepatocellular Carcinoma via Activation of RAF1/MEK/ERK Signaling Pathway

Cancer Science, EarlyView.
Hepatitis B virus (HBV) infection is a major driver of hepatocellular carcinoma (HCC) and is associated with resistance to sorafenib, the first‐line treatment for advanced HCC. This study demonstrates that the small HBV surface antigen (SHBs) promotes sorafenib resistance by activating the RAF1/MEK/ERK signaling pathway, inhibiting apoptosis in HCC ...
Shuxiang Wu, Yuxiang Hong, Hang Li, Mengxian Lin, Xiaohuang Lin, Xinjian Lin, Xu Lin   +6 more
wiley   +1 more source

How Do Cancer Cells Create Cancer‐Associated Fibroblast Subtypes? Impacts of Extracellular Vesicles on Stromal Diversity

Cancer Science, EarlyView.
Cancer‐associated fibroblasts (CAFs) are the major component of the tumor stroma. This review will highlight the CAF subtypes within the tumor microenvironment and their role in tumor progression. CAF subtype induction by extracellular vesicles (EVs) and their significance, which we reported previously, are also discussed.
Yutaka Naito
wiley   +1 more source

Chemotherapy-induced macrophage CXCL7 expression drives tumor chemoresistance via the STAT1/PHGDH-serine metabolism axis and SAM paracrine feedback to M2 polarization. [PDF]

Cell Death Dis
Liu S, Gong H, Li P, Hu J, Li Y, Xu R, Cai J, Wang S, Cai J, Ma H, Mi X, Li Y, Zhou Q, Zhou Q, Yang W, Li R, Song L, Fang L.   +17 more
europepmc   +1 more source

Intracrine vascular endothelial growth factor signaling in survival and chemoresistance of human colorectal cancer cells

, 2010
Samson Mathews Samuel, Fei Fan, Long H. Dang, Liangping Xia, Puja Gaur, Lee M. Ellis   +5 more
openalex   +1 more source

PRRX2 Regulates GLI2 to Promote Proliferation, Invasion, and Metastasis by Inhibiting Senescence via Hedgehog Signaling

Cancer Science, EarlyView.
PRRX2 is highly expressed in pancreatic cancer and correlates with patient prognosis. PRRX2 promotes pancreatic cancer cell proliferation, invasion, and metastasis, and inhibits pancreatic cancer cell senescence. PRRX2 transcriptionally regulates GLI2 and activates the Hedgehog pathway.
Wei Huang, Feiqiang xu, Jichuan xu, Gang Quan, Shihang zhang, Mengmeng guo, Feng xiao, Jianxin jiang   +7 more
wiley   +1 more source

Impact of poorly controlled type II diabetes mellitus on chemoresistance in colorectal cancer. [PDF]

World J Gastroenterol
Gaur A, Maity R, Dhali A, Biswas J.
europepmc   +1 more source

Synergistical Induction of Apoptosis via Cold Atmospheric Plasma and Nanohydroxyapatite for Selective Inhibition of Oral Squamous Cell Carcinoma in Tumour Microenvironment

Cell Proliferation, EarlyView.
The synergistic effects of microwave‐induced CAP and pH‐responsive NH2‐nHA on OSCC cells were investigated, unveiling novel molecular mechanisms. The study highlights CAP+NH2‐nHA's dual action, inducing diverse apoptotic pathways and establishing a ROS‐Ca2+ amplifying loop, promising in cancer therapy.
Wenting Qi, Hanghang Liu, Huaze Liu, Yuxuan Guo, Li Wu, Chongyun Bao, Xian Liu   +6 more
wiley   +1 more source