Results 31 to 40 of about 149,400 (379)
Genome expression analysis by suppression subtractive hybridization identified overexpression of Humanin, a target gene in gastric cancer chemoresistance [PDF]
, 2014 Background: In cancer cells, apoptosis is an important mechanism that influences the outcome of chemotherapy and the development of chemoresistance.
Ebrahimifard, F. +5 more
core +1 more source
Autophagy, 2021 Chemotherapy is currently the main treatment for unresectable or advanced postoperative gastric cancers. However, its efficacy is negatively affected by the occurrence of chemoresistance, which severely affects patient prognosis.
Yuhao Luo +13 more
semanticscholar +1 more source
Apoptosis and melanoma chemoresistance [PDF]
Oncogene, 2003 Melanoma is the most aggressive form of skin cancer and is notoriously resistant to all current modalities of cancer therapy. A large set of genetic, functional and biochemical studies suggest that melanoma cells become 'bullet proof' against a variety of chemotherapeutic drugs by exploiting their intrinsic resistance to apoptosis and by reprogramming ...
Scott W. Lowe, Maria S. Soengas
openaire +2 more sources
Identification of multidrug chemoresistant genes in head and neck squamous cell carcinoma cells
Molecular Cancer, 2023 Multidrug resistance renders treatment failure in a large proportion of head and neck squamous cell carcinoma (HNSCC) patients that require multimodal therapy involving chemotherapy in conjunction with surgery and/or radiotherapy.
Neha Khera +6 more
doaj +1 more source
Journal of experimental & clinical cancer research : CR, 2022 Background Stanniocalcin 1 (STC1) plays an integral role in ovarian cancer (OC). However, the functional role of STC1 in metastasis, lipid metabolism and cisplatin (DDP) chemoresistance in OC is not fully understood.
Feikai Lin +5 more
semanticscholar +1 more source
Redox control of multidrug resistance and Its possible modulation by antioxidants [PDF]
, 2016 Clinical efficacy of anticancer chemotherapies is dramatically hampered by multidrug resistance (MDR) dependent on inherited traits, acquired defence against toxins, and adaptive mechanisms mounting in tumours.
Cort, A. +4 more
core +3 more sources
Bioengineered, 2022 Chemoresistance in hepatocellular carcinoma (HCC) has been found to be influenced by exosomal transport of circRNAs. However, the role of circZFR in HCC chemoresistance still remains unclear.
Yun Zhou +6 more
semanticscholar +1 more source
Super-enhancers: a new frontier for epigenetic modifiers in cancer chemoresistance
Journal of Experimental & Clinical Cancer Research, 2021 Although new developments of surgery, chemotherapy, radiotherapy, and immunotherapy treatments for cancer have improved patient survival, the emergence of chemoresistance in cancer has significant impacts on treatment effects.
Guo-Hua Li +7 more
doaj +1 more source
Mitochondria and cancer chemoresistance
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2017 Mitochondria, known for more than a century as the energy powerhouse of a cell, represent key intracellular signaling hub that are emerging as important determinants of several aspects of cancer development and progression, including metabolic reprogramming, acquisition of metastatic capability, and response to chemotherapeutic drugs.
Guerra F., Arbini A. A., Moro L.
openaire +4 more sources
Frontiers in Pharmacology, 2021 Chemoresistance has become a prevalent phenomenon in cancer therapy, which alleviates the effect of chemotherapy and makes it difficult to break the bottleneck of the survival rate of tumor patients.
Jin-Feng Xu +9 more
doaj +1 more source