The role of epithelial-to-mesenchymal plasticity in ovarian cancer progression and therapy resistance [PDF]
, 2019 Ovarian cancer is the most lethal of all gynecologic malignancies and the eighth leading cause of cancer-related deaths among women worldwide. The main reasons for this poor prognosis are late diagnosis; when the disease is already in an advanced stage ...
Berx, Geert +3 more
core +2 more sources
Circular CPM promotes chemoresistance of gastric cancer via activating PRKAA2‐mediated autophagy
Clinical and Translational Medicine, 2022 Background Chemotherapy can significantly improve the disease‐free survival and overall survival of patients with advanced gastric cancer (GC). 5‐fluorouracil (5‐FU) is frequently applied in the clinic, acting as a first‐line chemotherapy drug of ...
L. Fang +17 more
semanticscholar +1 more source
ΔNp63-mediated regulation of hyaluronic acid metabolism and signaling supports HNSCC tumorigenesis [PDF]
, 2017 Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, and several molecular pathways that underlie the molecular tumorigenesis of HNSCC have been identified. Among them, amplification or overexpression of ΔNp63 isoforms
Anemone, Lucia +12 more
core +2 more sources
METTL3 mediates chemoresistance by enhancing AML homing and engraftment via ITGA4
Leukemia, 2022 Chemoresistant leukemia relapse is one of the most common causes of death for acute myeloid leukemia (AML) patients and the homing/engraftment in bone marrow (BM) are crucial steps for AML cells to acquire chemoresistance by interacting with stromal cell
Mingying Li +13 more
semanticscholar +1 more source
AKAP8L enhances the stemness and chemoresistance of gastric cancer cells by stabilizing SCD1 mRNA
Cell Death and Disease, 2022 Gastric cancer (GC) remains the third leading cause of cancer-related deaths. Chemoresistance is the major determinant of GC treatment failure. To explore the molecular mechanisms of GC chemoresistance, mass spectrometry was performed to detect the genes
Ruihong Zhang +10 more
doaj +1 more source
MiRNA-145 increases therapeutic sensibility to gemcitabine treatment of pancreatic adenocarcinoma cells. [PDF]
, 2016 Pancreatic adenocarcinoma is one of the most leading causes of cancer-related deaths worldwide. Although recent advances provide various treatment options, pancreatic adenocarcinoma has poor prognosis due to its late diagnosis and ineffective therapeutic
Chen, Qiu-Dan +8 more
core +2 more sources
Exploring role of 5hmC as potential marker of chemoresistance
Molecular & Cellular Oncology, 2020 Chemoresistance remains to be a common and significant hurdle with all chemotherapies. Tumors gain resistance by acquiring additional mutations. Some of the chemoresistance mechanisms are known and can be tackled. However, the majority of chemoresistance
Suhas S. Kharat, Shyam K. Sharan
doaj +1 more source
Endoglin Is Essential for the Maintenance of Self-Renewal and Chemoresistance in Renal Cancer Stem Cells. [PDF]
, 2017 Renal cell carcinoma (RCC) is a deadly malignancy due to its tendency to metastasize and resistance to chemotherapy. Stem-like tumor cells often confer these aggressive behaviors.
Dai, Jin +10 more
core +3 more sources
Chemoresistance and chemosensitization in cholangiocarcinoma
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2018 One of the main difficulties in the management of patients with advanced cholangiocarcinoma (CCA) is their poor response to available chemotherapy. This is the result of powerful mechanisms of chemoresistance (MOC) of quite diverse nature that usually act synergistically.
Marta R. Romero +10 more
openaire +4 more sources
Fatty acid 16:4(n-3) stimulates a GPR120-induced signaling cascade in splenic macrophages to promote chemotherapy resistance [PDF]
, 2017 Although chemotherapy is designed to eradicate tumor cells, it also has significant effects on normal tissues. The platinum-induced fatty acid 16:4(n-3) (hexadeca-4,7,10,13-tetraenoic acid) induces systemic resistance to a broad range of DNA-damaging ...
Daenen, Laura G.M. +15 more
core +2 more sources