Results 41 to 50 of about 133,761 (337)
OverAKT3: tumor progression and chemoresistance [PDF]
Cell Cycle, 2015 Akt3 is one of 3 closely related serine/threonine-protein kinases in the Akt family (Akt1, Akt2, and Akt3). Akt is among the most hyperactivated oncogenes in human cancer, regulating key cellular functions such as growth, proliferation, migration, invasion, angiogenesis, metabolism, and survival.1,2 Studies evaluating the effect of Akt isoform gene ...
Ping, Ji, Kristen M, Turner, Wei, Zhang
openaire +2 more sources
Tumor chemosensitivity and chemoresistance assays [PDF]
Cancer, 1996 Chemosensitivity and chemoresistance assays have been used to select potentially more effective chemotherapy regimens and to avoid the toxicity of potentially ineffective drugs.Literature review was conducted.The relevant outcome measure for chemosensitivity assays is improved patient survival.
E, Brown, M, Markman
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The Emerging Role of Exosomes in Cancer Chemoresistance
Frontiers in Cell and Developmental Biology, 2021 Chemoresistance is an impending challenge in cancer treatment. In recent years, exosomes, a subtype of extracellular vesicles with a diameter of 40–150 nm in bloodstream and other bio-fluids, have attracted increasing interest. Exosomes contain proteins,
Jing Li +8 more
doaj +1 more source
DNA methylation characteristics associated with chemotherapy resistance in epithelial ovarian cancer
HeliyonObjective: The high mortality rate of epithelial ovarian cancer (EOC) is often attributed to the frequent development of chemoresistance. DNA methylation is a predictive biomarker for chemoresistance. Methods: This study utilized DNA methylation profiles
Changling Duan +4 more
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C/EBPβ-1 promotes transformation and chemoresistance in Ewing sarcoma cells. [PDF]
, 2017 CEBPB copy number gain in Ewing sarcoma was previously shown to be associated with worse clinical outcome compared to tumors with normal CEBPB copy number, although the mechanism was not characterized.
Abegglen, Lisa M +12 more
core +1 more source
Glucocorticoid receptor signalling activates YAP in breast cancer [PDF]
, 2017 The Hippo pathway is an oncosuppressor signalling cascade that plays a major role in the control of cell growth, tissue homoeostasis and organ size. Dysregulation of the Hippo pathway leads to aberrant activation of the transcription co-activator YAP ...
Bertolio, Rebecca +12 more
core +3 more sources
MedCommColorectal liver metastases grow following different histologic growth patterns (HGPs), classified as desmoplastic and nondesmoplastic (dHGP, non‐dHGP), being the latter associated with worst prognosis.
Gemma Garcia‐Vicién +10 more
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Antioxidant and Anticancer Activity of Vitis vinifera Extracts in Breast Cell Lines
LifeVitis vinifera extracts have been shown to possess antioxidant activity because of their polyphenol content. In addition, their therapeutic potential against several diseases, including cancer, has been reported.
Evgenia Maria Tsantila +4 more
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Journal of Hematology & Oncology, 2019 Background Chemoresistance is one of the main causes of poor prognosis in pancreatic cancer patients. Understanding the mechanisms implicated in chemoresistance of pancreatic cancer is critical to improving patient outcomes.
Guangbing Xiong +12 more
doaj +1 more source
Hypoxia-inducible factor 1 alpha is required for the tumourigenic and aggressive phenotype associated with Rab25 expression in ovarian cancer [PDF]
, 2016 The small GTPase Rab25 has been functionally linked to tumour progression and aggressiveness in ovarian cancer and promotes invasion in three-dimensional environments.
Chalmers, Anthony J. +3 more
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