Results 51 to 60 of about 149,400 (379)

Loss of histone macroH2A1 in hepatocellular carcinoma cells promotes paracrine-mediated chemoresistance and CD4+CD25+FoxP3+ regulatory T cells activation [PDF]

, 2020
Rationale: Loss of histone macroH2A1 induces appearance of cancer stem cells (CSCs)-like cells in hepatocellular carcinoma (HCC). How CSCs interact with the tumor microenvironment and the adaptive immune system is unclear. Methods: We screened aggressive
Drovakova A., Giallongo S., Li Volti G., Lo Re O., Mazza T., Rappa F., Roskams T., Sanna P., Tsochatzis E., Van Haele M., Vinciguerra M., Vinh Luong T.   +11 more
core   +1 more source

RNA-binding protein ZCCHC4 promotes human cancer chemoresistance by disrupting DNA-damage-induced apoptosis

Signal Transduction and Targeted Therapy, 2022
RNA-binding proteins (RBPs) play important roles in cancer development and treatment. However, the tumor-promoting RBPs and their partners, which may potentially serve as the cancer therapeutic targets, need to be further identified. Here, we report that
Ha Zhu, Kun Chen, Yali Chen, Juan Liu, Xiaomin Zhang, Yumei Zhou, Qiuyan Liu, Bingjing Wang, Taoyong Chen, Xuetao Cao   +9 more
semanticscholar   +1 more source

The kinesin Eg5 inhibitor K858 induces apoptosis but also survivin-related chemoresistance in breast cancer cells [PDF]

, 2016
Inhibitors of kinesin spindle protein Eg5 are characterized by pronounced antitumor activity. Our group has recently synthesized and screened a library of 1,3,4-thiadiazoline analogues with the pharmacophoric structure of K858, an Eg5 inhibitor.
CARRADORI, Simone, DE IULIIS, FRANCESCA, giantulli, sabrina, GIUFFRIDA, Anna, MILANA, Bernardina, SALERNO, GERARDO, SCARPA, Susanna, SILVESTRI, Ida, Taglieri, Ludovica   +8 more
core   +1 more source

Chemoresistance in solid tumours

Annals of Oncology, 2006
Drug resistance is a major factor that limits the effectiveness ofchemotherapy. Tumours can be intrinsically resistant prior tochemotherapy, or resistance may be acquired during treatmentby tumours that are initially sensitive to chemotherapy [1].Furthermore, in the process of acquiring resistance, the tumourmay become cross-resistant to a range of ...
Patrick G. Johnston, Timothy R. Wilson, Daniel B. Longley   +2 more
openaire   +4 more sources

Predicting and Overcoming Taxane Chemoresistance [PDF]

Trends in Molecular Medicine, 2021
Taxanes are microtubule-targeting drugs used as cytotoxic chemotherapy to treat most solid tumors. The development of resistance to taxanes is a major cause of therapeutic failure and overcoming chemoresistance remains an important challenge to improve patient's outcome.
Clara Nahmias, Clara Nahmias, Maria M Haykal, Maria M Haykal, Hadia Moindjie, Hadia Moindjie, Sylvie Rodrigues-Ferreira, Sylvie Rodrigues-Ferreira   +7 more
openaire   +3 more sources

The Emerging Role of Exosomes in Cancer Chemoresistance

Frontiers in Cell and Developmental Biology, 2021
Chemoresistance is an impending challenge in cancer treatment. In recent years, exosomes, a subtype of extracellular vesicles with a diameter of 40–150 nm in bloodstream and other bio-fluids, have attracted increasing interest. Exosomes contain proteins,
Jing Li, Na Gao, Zhengfan Gao, Wei Liu, Bairen Pang, Xingli Dong, Yong Li, Yong Li, Tianli Fan   +8 more
doaj   +1 more source

Early Mechanisms of Chemoresistance in Retinoblastoma

Cancers, 2022
Retinoblastoma is the most common eye cancer in children and is fatal if left untreated. Over the past three decades, chemotherapy has become the mainstay of eye-sparing treatment. Nevertheless, chemoresistance continues to represent a major challenge leading to ocular and systemic toxicity, vision loss, and treatment failure.
Michelle G. Zhang, Jeffim N. Kuznetsoff, Dawn A. Owens, Ryan A. Gallo, Karthik Kalahasty, Anthony M. Cruz, Stefan Kurtenbach, Zelia M. Correa, Daniel Pelaez, J. William Harbour   +9 more
openaire   +2 more sources

Autophagy is associated with chemoresistance in neuroblastoma [PDF]

BMC Cancer, 2016
Neuroblastoma (NB) is a frequent pediatric tumor characterized by a poor prognosis where a majority of tumors progress despite intensive multimodality treatments. Autophagy, a self-degradative process in cells, could be induced by chemotherapy and be associated with chemoresistance.
Assila Belounis, Roxane Le Gall, Mohamed Mahma, Hervé Sartelet, Mona Beaunoyer, Pierre Teira, Carine Nyalendo, Sonia Cournoyer, Gilles Vassal, Tina V. Imbriglio, Elie Haddad   +10 more
openaire   +3 more sources

HSPB1 facilitates chemoresistance through inhibiting ferroptotic cancer cell death and regulating NF-κB signaling pathway in breast cancer

bioRxiv, 2022
Chemoresistance is one of the major causes of therapeutic failure and poor prognosis for breast cancer patients, especially for triple-negative breast cancer patients. However, the underlying mechanism remains elusive.
Yiran Liang, Yajie Wang, Yan Zhang, F. Ye, Dan Luo, Yaming Li, Yuhan Jin, Dianwen Han, Zekun Wang, Bing Chen, Wenjing Zhao, Lijuan Wang, Xi Chen, T. Ma, Xiaoli Kong, Qifeng Yang   +15 more
semanticscholar   +1 more source

Essential gene pathways for glioblastoma stem cells: clinical implications for prevention of tumor recurrence. [PDF]

, 2011
Glioblastoma (World Health Organization/WHO grade IV) is the most common and most aggressive adult glial tumor. Patients with glioblastoma, despite being treated with gross total resection and post-operative radiation/chemotherapy, will almost always ...
Choe, Jinny, Liau, Linda M, Liu, Yue, Tso, Cho-Lea, Tso, Jonathan, Yamada, Kazunari, Ye, Fei   +6 more
core   +1 more source