Results 61 to 70 of about 149,400 (379)

Sec62 promotes stemness and chemoresistance of human colorectal cancer through activating Wnt/β-catenin pathway

Journal of experimental & clinical cancer research : CR, 2021
Background Cancer stem cell (CSC)-related chemoresistance leads to poor outcome of the patients with colorectal cancer (CRC). In this study, we identified the chemoresistance-relevant molecules and decipher the involved mechanisms to provide potential ...
Xiaofeng Liu, Kun Su, Xiaoyan Sun, Yangsen Jiang, Li-Jun Wang, Chenyu Hu, Chun-feng Zhang, Min Lu, Xiaojuan Du, B. Xing   +9 more
semanticscholar   +1 more source

Transforming Growth Factor Alpha Stimulation of Mucosal Tissue Cultures from Head and Neck Squamous Cell Carcinoma Patients Increases Chemoresistance to Cisplatin [PDF]

, 2010
The monoclonal epidermal growth factor receptor ( EGFR) antibody cetuximab (Erbitux(TM)) was recently approved by the European Medicines Agency for the treatment of recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC) in combination ...
Baumeister, Philipp, Harreus, Ulrich, Reiter, Maximilian, Schwenk-Zieger, Sabina   +3 more
core   +1 more source

SOX2 promotes chemoresistance, cancer stem cells properties, and epithelial–mesenchymal transition by β-catenin and Beclin1/autophagy signaling in colorectal cancer

Cell Death and Disease, 2021
Sex-determining region Y-box2 (SOX2), a master regulator of embryonic and induced pluripotent stem cells, drives cancer stem cells (CSCs) properties, fuels tumor initiation, and contributes to tumor aggressiveness. Our previous study has demonstrated the
Yin-fang Zhu, Shimiao Huang, Shengyuan Chen, Jiaxuan Chen, Zhiqing Wang, Yadong Wang, Haoxuan Zheng   +6 more
semanticscholar   +1 more source

Desmoplasia and Chemoresistance in Pancreatic Cancer [PDF]

Cancers, 2014
Pancreatic ductal adenocarcinoma (PDAC) occurs mainly in people older than 50 years of age. Although great strides have been taken in treating PDAC over the past decades its incidence nearly equals its mortality rate and it was quoted as the 4th leading cause of cancer deaths in the U.S. in 2012.
Rainer Heuchel, Ralf Faissner, Patrick Michl, Wolfgang Hagmann, J.-Matthias Löhr, Cornelius Weidenauer, Stephan L. Haas, Ralf Jesenofsky, Marvin Schober   +8 more
openaire   +3 more sources

Identification of key genes and pathways related to cancer-associated fibroblasts in chemoresistance of ovarian cancer cells based on GEO and TCGA databases

Journal of Ovarian Research, 2022
Background Studies have revealed the implications of cancer-associated fibroblasts (CAFs) in tumor progression, metastasis, and treatment resistance.
Li Han, Xiaojuan Guo, Ruijuan Du, Kelei Guo, Pei Qi, Hua Bian   +5 more
doaj   +1 more source

Insights into Chemoresistance of Prostate Cancer [PDF]

International Journal of Biological Sciences, 2015
Prostate cancer (PCa) remains the most prevalent malignancy among males in the western world. Though hormonal therapies through chemical or surgical castration have been proposed many years ago, heretofore, such mainstay for the treatment on advanced PCa has not fundamentally changed.
Yan Meng, Tao Yang, Xiao-Fei Wen, Wei Zhang, Na Liu   +4 more
openaire   +2 more sources

Mitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance

Nature Communications, 2021
Chemotherapy remains the standard of care for most cancers worldwide, however development of chemoresistance due to the presence of the drug-effluxing ATP binding cassette (ABC) transporters remains a significant problem.
Emily L. Giddings, D. Champagne, Meng-Han Wu, Joshua M. Laffin, T. Thornton, Felipe Valença-Pereira, Rachel Culp-Hill, K. Fortner, N. Romero, J. East, Phoebe Cao, H. Arias-Pulido, Karatatiwant S Sidhu, Brian Silverstrim, Y. Kam, S. Kelley, Mark P. Pereira, S. Bates, J. Bunn, S. Fiering, D. Matthews, R. Robey, Domink Stich, A. D’Alessandro, M. Rincón   +24 more
semanticscholar   +1 more source

p53 Signaling on Microenvironment and Its Contribution to Tissue Chemoresistance

Membranes, 2022
Chemoresistance persists as a significant, unresolved clinical challenge in many cancer types. The tumor microenvironment, in which cancer cells reside and interact with non-cancer cells and tissue structures, has a known role in promoting every aspect ...
Leonel Cardozo de Menezes e Souza, Anderson Faletti, Carla Pires Veríssimo, Mariana Paranhos Stelling, Helena Lobo Borges   +4 more
doaj   +1 more source

Challenges of drug resistance in the management of pancreatic cancer [PDF]

, 2010
The current treatment of choice for metastatic pancreatic cancer involves single agent gemcitabine or combination of gemcitabine with capecitabine and erlotinib (tyrosine kinase inhibitor).
Akada, Allison, Almoguera, Andreetta, Arai, Arlt, Arteaga, Arumugam, Asano, Bachem, Baldwin, Banerjee, Bartsch, Bergers, Best, Bold, Bondar, Buck, Burris, Chakravarti, Chakravarti, Choi, Cunningham, Cunningham, Dancer, Dong, Duxbury, Duxbury, Duxbury, Duxbury, Engelman, Feldmann, Ferrero, Galmarini, Geyer, Giovannetti, Goan, Greer, Hagmann, Hahn, Henke, Hruban, Humeniuk, Ischenko, Ishikawa, Itoi, Jansen, Karapetis, Kindler, Kong, Koopman, Kulik, Lei, Lemoine, Liau, Liau, Longley, Mackey, Mackey, Mackey, Mahon, Mamaghani, Marechal, Marmor, Martin Clynes, Mata, Maxwell, Mendelsohn, Meropol, Miwa, Moertel, Molina-Arcas, Moore, Morgillo, Moriyama, Muerkoster, Muerkoster, Nakahira, Nakajima, Nakano, Naomi Walsh, Nishimura, Oguri, Okamoto, Okumura, Olive, O’Driscoll, Pao, Park, Park, Peters, Plunkett, Ray McDermott, Ritzel, Rizwan Sheikh, Robert O’Connor, Ruggeri, Safran, Saito, Sakamoto, Schuller, Sebastiani, Shah, Shi, Simon, Spratlin, Takao, Takebayashi, Treat, Tsukamoto, Tzeng, Vaishampayan, Van Cutsem, van der Wilt, Wang, Wang, Wang, Xiong, Yamasaki, Yokoi   +119 more
core   +1 more source

CCL18 signaling from tumor-associated macrophages activates fibroblasts to adopt a chemoresistance-inducing phenotype

Oncogene, 2022
The heterogeneity of cancer-associated fibroblasts (CAFs) might be ascribed to differences in origin. CD10 and GPR77 have been reported to identify a chemoresistance-inducing CAF subset in breast cancer.
Wenfeng Zeng, Lixiong Xiong, Wei Wu, Shunrong Li, Jiang Liu, Linbin Yang, Liyan Lao, Penghan Huang, Meng-meng Zhang, Huiping Chen, Nanyan Miao, Zhirong Lin, Zifei Liu, Xinyu Yang, Jiayi Wang, Pei Wang, Erwei Song, Yandan Yao, Yan Nie, Jianing Chen, Di Huang   +20 more
semanticscholar   +1 more source