Results 71 to 80 of about 149,400 (379)
Chloroquine plays a cell-dependent role in the response to treatment of pancreatic adenocarcinoma [PDF]
, 2018 In this study, our aim is to assess the role played by autophagy and its inhibition in the different PDAC cellular compartments, and its involvement in chemo-resistance using primary human pancreatic cancer-derived cells (PCC) and Cancer Associated ...
Bintz, Jennifer +6 more
core +1 more source
Theranostics, 2018 Long non-coding RNAs (lncRNAs) are involved in the pathology of various tumors, including colorectal cancer (CRC). The crosstalk between carcinoma- associated fibroblasts (CAFs) and cancer cells in the tumor microenvironment promotes tumor development ...
Jing Ren +8 more
semanticscholar +1 more source
Role of microRNAs in chemoresistance.
Annals of translational medicine, 2015 Drug resistance is a major problem in the treatment of cancer patients. Resistance can develop after prolonged cycles of chemotherapy or can be present intrinsically in the patient. There is an emerging role of microRNAs (miRNAs) in resistance to cancer treatments.
Michela Garofalo, Peter Magee, Lei Shi
openaire +4 more sources
Current Opinions on Chemoresistance: An Overview [PDF]
Bioinformation, 2018 Sub population of cancer cells, referred to as Cancer stem cells (CSCs) or tumor initiating cells, have enhanced metastatic potential that drives tumor progression. CSCs have been found to hold intrinsic resistance to present chemotherapeutic strategies. This resistance is attributed to DNA reparability, slower cell cycle and high levels of detoxifying
Ruba Y. Taha, Saba Hasan, Halima El Omri
openaire +3 more sources
C/EBPβ-1 promotes transformation and chemoresistance in Ewing sarcoma cells. [PDF]
, 2017 CEBPB copy number gain in Ewing sarcoma was previously shown to be associated with worse clinical outcome compared to tumors with normal CEBPB copy number, although the mechanism was not characterized.
Abegglen, Lisa M +12 more
core +1 more source
Exosomes in the Chemoresistance of Glioma: Key Point in Chemoresistance
Journal of Cellular and Molecular MedicineABSTRACTGliomas are the most ordinary primary virulent brain tumours and commonly used clinical treatments include tumour resection, radiation therapy and chemotherapy. Although significant progress has been made in recent years in progression‐free survival (PFS) and overall survival (OS) for patients with high‐grade gliomas, the prognosis for patients
Xu Guo, Haozhe Piao, Rui Sui
openaire +2 more sources
Pancreatic Cancer Chemoresistance to Gemcitabine [PDF]
Cancers, 2017 Pancreatic ductal adenocarcinoma (PDAC), commonly referred to as pancreatic cancer, ranks among the leading causes of cancer-related deaths in the Western world due to disease presentation at an advanced stage, early metastasis and generally a very limited response to chemotherapy or radiotherapy.
Manoj Amrutkar, Ivar Gladhaug
openaire +3 more sources
Journal of Ovarian Research, 2023 Background Chemotherapy is among the most common treatment methods for ovarian cancer (OC). However, chemoresistance limits the effectiveness of chemotherapy and leads to treatment failure.
Shufen Wang +6 more
doaj +1 more source
MedCommColorectal liver metastases grow following different histologic growth patterns (HGPs), classified as desmoplastic and nondesmoplastic (dHGP, non‐dHGP), being the latter associated with worst prognosis.
Gemma Garcia‐Vicién +10 more
doaj +1 more source
p63 is an alternative p53 repressor in melanoma that confers chemoresistance and a poor prognosis. [PDF]
, 2013 The role of apoptosis in melanoma pathogenesis and chemoresistance is poorly characterized. Mutations in TP53 occur infrequently, yet the TP53 apoptotic pathway is often abrogated.
Akslen +143 more
core +1 more source