Results 71 to 80 of about 64,721 (205)

Extracellular Vesicular Delta‐Like Ligand 3 and Subtype Transcription Factors for Small Cell Lung Cancer Diagnosis

Advanced Science, EarlyView.
Small cell lung cancer (SCLC) harbors high molecular heterogeneity. Using a new liquid biopsy assay, SCLC subtypes can be identified by measuring mRNA of subtype transcription factors (ASCL1, POU2F3, and NEUROD1) in exosome‐rich extracellular vesicles. Combining with Delta‐like ligand 3 (DLL3) mRNA in exosomes and its membrane protein in extracellular ...
Hong Li, Chi‐Ling Chiang, Kwang Joo Kwak, Hsin‐Lun Lee, Xinyu Wang, Giulia Romano, Michela Saviana, Robin Toft, Tai‐Shan Cheng, Yuehshih Chang, Bi‐Da Hsiang, Guan‐Wan Liu, Xiaokui Mo, Yifan Ma, Junjie Pan, Xilal Y. Rima, Truc Nguyen Kim, Eduardo Reategui, Chia‐Ning Shen, Yeh‐Shiu Chu, Carlo Croce, Peter Mu‐Hsin Chang, Yi‐Chen Yeh, David P. Carbone, Chi‐Ying F. Huang, Chi‐Lu Chiang, Patrick Nana‐Sinkam, L. James Lee   +27 more
wiley   +1 more source

Colloidal Polyelectrolyte Complexes from Hyaluronic Acid: Preparation and Biomedical Applications

Small, Volume 18, Issue 51, December 22, 2022., 2022
Hyaluronic acid (HA) is a very promising polysaccharide for biomedical applications. This review provides a comprehensive overview of the development of nanoparticulate systems by HA‐based polyelectrolyte complexation. The main achievements and applications for the delivery of active substances or the construction of multifunctional platforms are ...
Huu Van Le, Didier Le Cerf
wiley   +1 more source

CRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer

Nature Communications
Resistance to chemotherapy has been a major hurdle that limits therapeutic benefits for many types of cancer. Here we systematically identify genetic drivers underlying chemoresistance by performing 30 genome-scale CRISPR knockout screens for seven ...
Chunge Zhong, Wen-Jie Jiang, Yingjia Yao, Zexu Li, You Li, Shengnan Wang, Xiaofeng Wang, Wenjuan Zhu, Siqi Wu, Jing Wang, Shuangshuang Fan, Shixin Ma, Yeshu Liu, Han Zhang, Wenchang Zhao, Lu Zhao, Yi Feng, Zihan Li, Ruifang Guo, Li Yu, Fengyun Pei, Jun Hu, Xingzhi Feng, Zihuan Yang, Zhengjia Yang, Xueying Yang, Yue Hou, Danni Zhang, Dake Xu, Ren Sheng, Yihao Li, Lijun Liu, Hua-Jun Wu, Jun Huang, Teng Fei   +34 more
doaj   +1 more source

Identification of An mtDNA Setpoint Associated with Highest Levels of CD44 Positivity and Chemoresistance in HGC-27 and MKN-45 Gastric Cancer Cell Lines

Cell Journal, 2018
Objective Cancer stem cells (CSCs) have important roles in survival and chemoresistance. These cells are commonly recognized with CD44 and CD24 markers.
Gökhan Terzioğlu, Özlem Türksoy, Ömer Faruk Bayrak   +2 more
doaj   +1 more source

PRMT1‐Mediated SWI/SNF Complex Recruitment via SMARCC1 Drives IGF2BP2 Transcription to Enhance Carboplatin Resistance in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
PRMT1 drives carboplatin resistance and tumor progression in head and neck squamous cell carcinoma (HNSCC) through a novel, methyltransferase‐independent mechanism. It recruits the SWI/SNF complex to activate IGF2BP2, promoting tumor growth and carboplatin resistance. PBX2 upregulates PRMT1, reinforcing this pathway. This study uncovers a non‐catalytic
Shixian Liu, Wentao Zhang, Weiwei Liu, Zhao Ding, Ruijing Zhang, Yuefeng Han, Zihao Niu, Mengdie Zhang, Hui Li, Dapeng Li, Zixi Wang, Jie Peng, Yu Wu, Yanxun Han, Zihui Xie, Jing Wu, Liang Qin, Zhongdong Hu, Xu Chen, Yunlong Hu, Yehai Liu, Shiyin Ma, Xiaojun Zha   +22 more
wiley   +1 more source

Ubiquitin-Specific Peptidase 22 Contributes to Colorectal Cancer Stemness and Chemoresistance via Wnt/β-Catenin Pathway

Cellular Physiology and Biochemistry, 2018
Background/Aims: Two major barriers to the successful treatment of colorectal cancer (CRC) are the development of stem cell-like characteristics (stemness) and chemoresistance.
Shixiong Jiang, Chenxin Song, Xinyu Gu, Muhong Wang, Dazhuang Miao, Jiachen Lv, Yanlong Liu   +6 more
doaj   +1 more source

CCN1 Enhances Tumor Immunosuppression through Collagen‐Mediated Chemokine Secretion in Pancreatic Cancer

Advanced Science, EarlyView.
CCN1 modulates the tumor microenvironment in pancreatic cancer by promoting collagen‐dependent chemokine production, thereby facilitating immune evasion. Deletion of CCN1 not only suppresses tumor growth but also enhances immune cell infiltration and increases tumor sensitivity to both chemotherapy and immunotherapy.
Hongjie Fan, Huzi Zhao, Lili Gao, Yucheng Dong, Pei Zhang, Pengfei Yu, Yunfei Ji, Zhe‐Sheng Chen, Xinmiao Liang, Yang Chen   +9 more
wiley   +1 more source

HDAC6 and USP9X Control Glutamine Metabolism by Stabilizing GS to Promote Glioblastoma Tumorigenesis

Advanced Science, EarlyView.
Glioblastoma (GBM) growth relies on glutamine synthetase (GS), which is stabilized by histone deacetylase 6 (HDAC6) and deubiquitinated by ubiquitin‐specific peptidase 9, X‐linked (USP9X). HDAC6 promotes GS deacetylation, while USP9X removes its K48‐linked polyubiquitination, enhancing GS stability.
Go Woon Kim, Minhae Cha, Hien Thi My Ong, Jung Yoo, Yu Hyun Jeon, Sang Wu Lee, Soo Yeon Oh, Min‐Jung Kang, Youngsoo Kim, So Hee Kwon   +9 more
wiley   +1 more source

Self‐Propelled In Situ Polymerized Nanoparticles Activating the STING Pathway for Enhanced Bladder Cancer Immunotherapy

Advanced Science, EarlyView.
A self‐propelled nanomedicine delivery system forms DMCU nanoparticles in the bladder via in situ polymerization of dopamine hydrochloride, Mn2+, cGAMP, and urease. The urease‐driven propulsion enhances retention and drug delivery. These nanoparticles activate the STING pathway, stimulating dendritic cells and T cells to boost anti‐bladder cancer ...
Lei Peng, Anguo Zhao, Rongkang Li, Yujun Liu, Daitian Tang, Dashi Deng, Qi Zhuang, Rui Liang, Shaohua Zhang, Song Wu   +9 more
wiley   +1 more source

Genetic variants in LKB1/AMPK/mTOR pathway are associated with clinical outcomes of chemotherapy in non‐small cell lung cancer

Thoracic Cancer, Volume 13, Issue 23, Page 3322-3330, December 2022., 2022
Alterations in LKB1/AMPK and downstream pathway may modify the response of cancer cells to chemotherapy and clinical outcomes. This study showed that two genetic variants in LKB1/AMPK/mTOR pathway, the AKT1 rs2494750G〉C and TSC1 rs2809244C〉A, were associated with the clinical outcomes after paclitaxel‐cisplatin chemotherapy in patients with advanced ...
Sun Ha Choi, Sook Kyung Do, Shin Yup Lee, Jin Eun Choi, Hyo‐Gyoung Kang, Mi Jeong Hong, Jang Hyuck Lee, Won Kee Lee, Ji Yun Jeong, Kyung Min Shin, Young Woo Do, Eung Bae Lee, Ji Eun Park, Yong Hoon Lee, Hyewon Seo, Seung Soo Yoo, Jaehee Lee, Seung Ick Cha, Chang Ho Kim, Jae Yong Park   +19 more
wiley   +1 more source