Results 1 to 10 of about 65,117 (210)

Molecular Subtypes and Immune Microenvironment Characterization of the Annulus Fibrosus in Intervertebral Disc Degeneration: Insights From Translation Factor-Related Gene Analysis. [PDF]

JOR Spine
TFGs are valuable for distinguishing between different IVDD clusters. The predictive model developed demonstrates strong performance in forecasting IVDD. A thorough analysis of these clusters can contribute to a deeper understanding of the molecular mechanisms of IVDD.
Zheng S, Zhao X, Wu H, Cuan X, Cheng X, He D.   +5 more
europepmc   +2 more sources

In vivo imaging and quantitative analysis of leukocyte directional migration and polarization in inflamed tissue [PDF]

, 2009
Directional migration of transmigrated leukocytes to the site of injury is a central event in the inflammatory response. Here, we present an in vivo chemotaxis assay enabling the visualization and quantitative analysis of subtype-specific directional ...
Alexander Georg Khandoga, Andrej Khandoga, B Heit, B Heit, C Auffray, C Sumen, C Weber, CA Reichel, Christoph Andreas Reichel, CX Sun, D Carstanjen, D Vestweber, DA Schuschke, F Wegmann, Fritz Krombach, G Bardi, G Migliorisi, Howard E. Gendelman, IG Colditz, J Alblas, J Middleton, J Werr, K Ley, K Ley, M Pruenster, Markus Rehberg, MD Cahalan, MJ Hickey, MJ Redd, MX Wan, O Soehnlein, P Friedl, Peter Bihari, RA Worthylake, RE Young, RJ Linhardt, RR Kay, S Baez, S Miyazaki, S Normark, S Nourshargh, SY Bae, T Lammermann, TA Russo, TR Mempel, V Niggli, WA Muller, WG Tharp   +47 more
core   +14 more sources

Metallothionein mediates leukocyte chemotaxis [PDF]

BMC Immunology, 2005
AbstractBackgroundMetallothionein (MT) is a cysteine-rich, metal-binding protein that can be induced by a variety of agents. Modulation of MT levels has also been shown to alter specific immune functions. We have noticed that the MT genes map close to the chemokines Ccl17 and Cx3cl1.
Xiuyun Yin, Michael A. Lynes, David A. Knecht   +2 more
openaire   +4 more sources

Preinfection in vitro chemotaxis, phagocytosis, oxidative burst, and expression of CD11/CD18 receptors and their predictive capacity on the outcome of mastitis induced in dairy cows with Escherichia coli. [PDF]

, 1997
Four to 6 wk after parturition, 12 cows in second, fourth, or fifth lactation were experimentally infected in one gland with Escherichia coli. The capacity of chemotaxis, phagocytosis, oxidative burst, and expression of CD11/CD18 receptors to predict the
A. Brand, A.J.J.M. Daemen, Arfors, Burton, Burvenich, C. Burvenich, Cai, Caroll, Chenoweth, E.N. Noordhuizen-Stassen, Gelfand, Gilbert, Heyneman, Hill, Kehrli, Kehrli, Kremer, Lohuis, Myllys, Nagahata, Paape, Rainard, Saad, Schukken, Shuster, Simpson, Smith, Splitter, T. Van Werven, van Werven, Y.H. Schukken   +30 more
core   +2 more sources

Psoriasis and Leukocyte Chemotaxis.

Journal of Investigative Dermatology, 1987
Transepidermal migration of leukocytes, with resultant formation of microscopic or macroscopic sterile subcorneal pustules is a phenomenon characteristically noted in psoriasis and related sterile pustular dermatoses. It is natural to assume the presence of potent neutrophil chemotactic substances in the subcorneal portion of the lesional epidermis ...
Hideaki Takematsu, Keiji Iwatsuki, Hachiro Tagami   +2 more
openaire   +3 more sources

Identification of an alternative G{alpha}q-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytes [PDF]

, 2007
CD38 controls the chemotaxis of leukocytes to some, but not all, chemokines, suggesting that chemokine receptor signaling in leukocytes is more diverse than previously appreciated.
Borchers, Michael T., Lee, James J., Lund, Frances E., Misra, Ravi S., Partida-Sánchz, Santiago, Shi, Guixiu, Simon, Melvin I., Tighe, Michael   +7 more
core   +2 more sources

Blood polymorphonuclear leukocyte chemotaxis during experimental escherichia-coli bovine mastitis. [PDF]

, 1993
The relationship between the severity of experimental Escherichia coli mastitis and the chemotactic response of blood polymorphonuclear leukocytes was investigated before and during mastitis. Experimental E.
A. Brand, A.J.J.M. Daemen, Brown, Burvenich, C. Burvenich, E.N. Noordhuizen-Stassen, Ellis, F.J. Grommers, Grommers, Heyneman, Hill, Hill, Jain, Jain, Kehrli, Kremer, Kremer, Lohuis, Löfstadt, Mowat, Nagahata, Nelson, Paape, Reid, W.D.J. Kremer   +24 more
core   +1 more source

Anti‐atherosclerotic effect of the angiotensin 1–7 mimetic AVE0991 is mediated by inhibition of perivascular and plaque inflammation in early atherosclerosis [PDF]

, 2017
Background and Purpose: Inflammation plays a key role in atherosclerosis. A protective role of angiotensin-(1-7) in vascular pathologies opened a possibility for therapeutic use of small molecule non-peptide Ang-(1-7) mimetics, such as AVE0991.
Czesnikiewicz-Guzik, M., Guzik, T.J., Jawien, J., Korbut, R., Mikolajczyk, T.P., Montezano, A.C., Nosalski, R., Olszanecki, R., Rios, F.J., Siedlinski, M., Skiba, D.S., Touyz, R.M.   +11 more
core   +2 more sources

Denervated Schwann cells attract macrophages by secretion of leukemia inhibitory factor (LIF) and monocyte chemoattractant protein-1 in a process regulated by interleukin-6 and LIF [PDF]

, 2002
Injury to peripheral nerves results in the infiltration of immune cells, which remove axonal- and myelin-derived material. Schwann cells could play a key role in this process by regulating macrophage infiltration.
Jessen, KR, Mirsky, R, Patterson, PH, Tofaris, GK   +3 more
core   +2 more sources

Skap2 is required for β2 integrin-mediated neutrophil recruitment and functions. [PDF]

, 2017
Integrin activation is required for neutrophil functions. Impaired integrin activation on neutrophils is the hallmark of leukocyte adhesion deficiency (LAD) syndrome in humans, characterized by impaired leukocyte recruitment and recurrent infections. The
Bardel, Bernadette, Block, Helena, Bokemeyer, Arne, Boras, Mark, Heitplatz, Barbara, Kliche, Stefanie, Lowell, Clifford, Reinhold, Annegret, Rossaint, Jan, Van Marck, Veerle, Volmering, Stephanie, Zarbock, Alexander   +11 more
core   +2 more sources