Results 111 to 120 of about 19,115 (229)

Discovery of macrocyclic inhibitors of apurinic/apyrimidinic endonuclease 1 [PDF]

, 2019
Apurinic/apyrimidinic endonuclease 1 (APE1) is an essential base excision repair enzyme that is upregulated in a number of cancers, contributes to resistance of tumors treated with DNA-alkylating or -oxidizing agents, and has recently been identified as ...
Beglov, Dmitri, Brown, Lauren E., Chen, Qiujia, Chennamadhavuni, Spandan, Georgiadis, Millie M., He, Hongzhen, Kelley, Mark R., Panek, James S., Porco, John A., Reed, April, Trilles, Richard, Vajda, Sandor, Wireman, Randall   +12 more
core   +7 more sources

The BAHD Acyltransferase Gene Family: Evolutionary Dynamics, Biochemical Mechanisms, and Roles in Plant Stress Adaptation

Plant Biotechnology Journal, EarlyView.
BAHD acyltransferases drive metabolic diversification in plants by coupling conserved catalytic scaffolds with regulatory flexibility, enabling stress adaptation and ecological specialisation. ABSTRACT BAHD acyltransferases constitute one of the most versatile enzyme superfamilies in plants, catalysing the acylation of alcohols, amines, polyamines, and
Muhammad Mubashar Zafar, Qiao Fei, Abdul Razzaq, Ayesha Siddiqua, Ayesha Naveed, M. Nasir Khan, Huma Saleem, Xuefei Jiang   +7 more
wiley   +1 more source

Structure‐Guided Optimization and Biological Validation of 1,3,4‐Thiadiazole‐Based SIRT2 Inhibitors Reinforcing Channel Entrance Interactions

Drug Development Research, Volume 87, Issue 2, April 2026.
ABSTRACT SIRT2, the cytoplasmic member of the sirtuin family, is generally acknowledged to promote cancer and contribute to the progression of various pathologies, including neurodegeneration, inflammation, obesity, and bacterial infection through the deacetylation of target substrates.
Ahmet Bugra Aksel, Fikriye Ozgencil, Filiz Bakar‐Ates, Habibe Beyza Gunindi, Alberto Massarotti, Erva Ozkan, Selen Gozde Kaya, Mahmut Gozelle, Yesim Ozkan, Gokcen Eren   +9 more
wiley   +1 more source

Essential oil composition from twelve varieties of basil (Ocimum spp) grown in Colombia

Journal of the Brazilian Chemical Society, 2003
Essential oil compositions of aerial parts from twelve basil cultivars (Ocimum spp) were analysed by gas chromatography-mass spectrometry (GC-MS). Ten of them were characterized by the presence of a high percentage of methyl cinnamate (35-80%), which ...
Viña Amparo, Murillo Elizabeth
doaj  

The Metabolic Fate of Deoxynivalenol and Its Acetylated Derivatives in a Wheat Suspension Culture: Identification and Detection of DON-15-O-Glucoside, 15-Acetyl-DON-3-O-Glucoside and 15-Acetyl-DON-3-Sulfate

Toxins, 2015
Deoxynivalenol (DON) is a protein synthesis inhibitor produced by the Fusarium species, which frequently contaminates grains used for human or animal consumption.
Clemens Schmeitzl, Benedikt Warth, Philipp Fruhmann, Herbert Michlmayr, Alexandra Malachová, Franz Berthiller, Rainer Schuhmacher, Rudolf Krska, Gerhard Adam   +8 more
doaj   +1 more source

Paracrine effects of TLR4-polarised mesenchymal stromal cells are mediated by extracellular vesicles [PDF]

, 2016
Mesenchymal stromal cells (MSCs) are adult stem cells able to give rise to bone, cartilage and fat cells. In addition, they possess immunomodulatory and immunosuppressive properties that are mainly mediated through secretion of extracellular vesicles ...
A Montecalvo, A Ozinsky, A Sharma, AK Ludwig, AM Piccinini, Bernd Denecke, Bernd Giebel, C Mayr, CA Dumitru, CH Hwa, D Ti, Darius Widera, F Liotta, G Raposo, GG Teng, I Zanoni, JC Kagan, JG Tidball, Ketan Patel, L Kordelas, L Timmers, L Zanotti, M Al-Nbaheen, M Gnecchi, M Gnecchi, M Yanez-Mo, M Zeuner, Marie-Theres Zeuner, MG Netea, MW Verghese, PA Zuk, R Secunda, RC Lai, RH Lee, RR Sharma, RS Waterman, S Bruno, S Tsuchiya, SC Lee, T Kawai, T Lener, TR Doeppner, W Chanput, Y Wang   +43 more
core   +1 more source

Comparative 1H NMR Metabolomics Between Scandinavian Propolis and Australian Propolis: The Quest to Identify Radical Scavenging Compounds

Magnetic Resonance in Chemistry, Volume 64, Issue 4, Page 438-450, April 2026.
Propolis from Scandinavia and Australia was chemically characterized using 1H NMR spectroscopy and multivariate modeling. Recursive partial least squares revealed spectral features associated with radical scavenging activity, and STOCSY enabled identification of the key phenolic compounds underlying these bioactive features. ABSTRACT Propolis from Apis
Jonas Vind, Søren Balling Engelsen, Henrik Munch Jørgensen, Julie Christine Antvorskov, Knud Josefsen, Violetta Aru   +5 more
wiley   +1 more source

In vitro evaluation of azole fungicide sensitivity in Fusarium langsethiae, F. tricinctum, F. poae and F. sporotrichioides populations from Irish oats

Pest Management Science, Volume 82, Issue 4, Page 3930-3941, April 2026.
Microtitre plate assays of 286 Irish oat isolates show species‐specific azole sensitivity. In Fusarium langsethiae, mefentrifluconazole and tebuconazole sensitivities correlate, defining four phenotypes and supporting resistance monitoring and integrated control.
Diana E. Bucur, Steven Kildea
wiley   +1 more source

chemotype

Citation: 'chemotype' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13001 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Bioactive Compound Profile and Nutrition Values of Kava (Piper methysticum) Cultivated in Fiji

Horticulturae
Piper methysticum G. Forst. (kava) is an important horticultural shrub of the Pacific, used as an ingredient of the intoxicating kava beverage, dietary supplement, and medicine around the globe.
Tibor Pasinszki, Deepti Darshani Devi, Melinda Krebsz   +2 more
doaj   +1 more source