Positive allosteric modulators of the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor [PDF]
, 2010 L-glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) and plays a fundamental role in the control of motor function, cognition and mood.
Grove, Simon J .A. +4 more
core +1 more source
Journal of Agricultural and Food Chemistry, 2014 Various vibrational spectroscopy methods have been applied to classify different fennel chemotypes according to their individual profile of volatile substances. Intact fennel fruits of different chemotypes could be successfully discriminated by attenuated total reflectance Fourier transform infrared (ATR-FTIR) and near infrared (NIR) spectroscopy ...
Krähmer, Andrea +4 more
openaire +3 more sources
Repellency Assessment of Nepeta cataria Essential Oils and Isolated Nepetalactones on Aedes aegypti. [PDF]
, 2019 There is an increased need for improved and affordable insect repellents to reduce transmission of rapidly spreading diseases with high mortality rates.
Dong, Xujun +6 more
core +2 more sources
Metabolite profiling characterises chemotypes of Musa diploids and triploids at juvenile and preflowering growth stages [PDF]
, 2019 Open Access Journal; Published online: 15 March 2019Bananas (Musa spp.) are consumed worldwide as dessert and cooking types. Edible banana varieties are for the most part seedless and sterile and therefore vegetatively propagated.
Amah, D. +9 more
core +2 more sources
Closing the Yield Gap for Cannabis: A Meta-Analysis of Factors Determining Cannabis Yield
Frontiers in Plant Science, 2019 Until recently, the commercial production of Cannabis sativa was restricted to varieties that yielded high-quality fiber while producing low levels of the psychoactive cannabinoid tetrahydrocannabinol (THC).
Rachel Backer +10 more
doaj +1 more source
Plant chemical variation mediates soil bacterial community composition
Scientific Reports, 2023 An important challenge in the study of ecosystem function is resolving how plant antiherbivore chemical defence expression may influence plant-associated microbes, and nutrient release.
Robert W. Buchkowski +7 more
doaj +1 more source
A mass spectrometry-guided genome mining approach for natural product peptidogenomics. [PDF]
, 2011 Peptide natural products show broad biological properties and are commonly produced by orthogonal ribosomal and nonribosomal pathways in prokaryotes and eukaryotes.
Cimermancic, Peter +8 more
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
The differentiation of fibre- and drug type Cannabis seedlings by gas chromatography/mass spectrometry and chemometric tools [PDF]
, 2010 Cannabis cultivation in order to produce drugs is forbidden in Switzerland. Thus, law enforcement authorities regularly ask forensic laboratories to determinate cannabis plant's chemotype from seized material in order to ascertain that the plantation is ...
Anglada, F., Broséus, J., Esseiva, P.
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source