MYC Binding Near Transcriptional End Sites Regulates Basal Gene Expression, Read-Through Transcription, and Intragenic Contacts. [PDF]
Adv Sci (Weinh)MYC is a transcription factor (TF) that binds DNA near transcriptional start sites (TSSs) and within enhancer elements. Here, unappreciated sites of MYC binding in the vicinity of transcriptional end sites (TESs) of many genes in multiple cell types in association with numerous other TFs are described previously.
Wang H +5 more
europepmc +2 more sources
Viruses, 2021 It has been shown that the filamentous phage, Pf4, plays an important role in biofilm development, stress tolerance, genetic variant formation and virulence in Pseudomonas aeruginosa PAO1.
Muhammad Hafiz Ismail +7 more
doaj +1 more source
Induction of SOX17 with stimulation of WNT, TGF-beta, and FGF signaling drives embryonal carcinomas into the yolk-sac tumor lineage resulting in increased cisplatin resistance. [PDF]
Int J CancerWhat's new? Yolk‐sac tumor formation has been suggested to be an escape mechanism during therapy in patients with relapsing germ cell tumors. The molecular mechanisms inducing yolk‐sac tumor development from stem cell‐like precursor embryonal carcinomas remain unclear.
Kotthoff M +11 more
europepmc +2 more sources
Optimized protocols for ChIP-seq and deletion mutant construction in Pseudomonas syringae
STAR Protocols, 2021 Summary: Chromatin immunoprecipitation sequencing (ChIP-seq) is an efficient technique to identify the binding sites of transcription factors (TFs) in both eukaryotes and prokaryotes. However, its application in bacteria is very heterogeneous.
Chunyan Yao +3 more
doaj +1 more source
Deciphering the code for retroviral integration target site selection. [PDF]
PLoS Computational Biology, 2010 Upon cell invasion, retroviruses generate a DNA copy of their RNA genome and integrate retroviral cDNA within host chromosomal DNA. Integration occurs throughout the host cell genome, but target site selection is not random.
Federico Andrea Santoni +2 more
doaj +1 more source
#277 : Transcriptome Analysis Revealed a Delayed and Attenuated Estrogen Response in IUA Patients
Fertility & Reproduction, 2023 Background and Aims: Intrauterine adhesion (IUA) is characterized by the formation of scar tissue in the endometrium following a variety of insults such as endometrial damage, miscarriage, and infection.
Qi Guo
doaj +1 more source
Beyond position weight matrices: nucleotide correlations in transcription factor binding sites and their description [PDF]
, 2013 The identification of transcription factor binding sites (TFBSs) on genomic DNA is of crucial importance for understanding and predicting regulatory elements in gene networks.
Hakim, Vincent +2 more
core +7 more sources
Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency [PDF]
, 2020 The ATM kinase is a master regulator of the DNA damage response to double-strand breaks (DSBs) and a well-established tumour suppressor whose loss is the cause of the neurodegenerative and cancer-prone syndrome Ataxia-Telangiectasia (A-T).
Bernal Lozano, Cristina +10 more
core +3 more sources
STAR Protocols, 2022 Summary: Temporal profiling of DNA replication timing (RT) in combination with chromatin modifications, chromatin accessibility, and gene expression provides new insights into the causal relationships between chromatin and RT during cell cycle.
Fei Ji +3 more
doaj +1 more source
Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression. [PDF]
, 2016 The unintended consequences of gene targeting in mouse models have not been thoroughly studied and a more systematic analysis is needed to understand the frequency and characteristics of off-target effects.
Adkisson, Michael +9 more
core +8 more sources