Results 1 to 10 of about 328,477 (299)
Novel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway Diseases [PDF]
Mediators of Inflammation, 2015 Chloride transport proteins play critical roles in inflammatory airway diseases, contributing to the detrimental aspects of mucus overproduction, mucus secretion, and airway constriction.
Monica Sala-Rabanal +3 more
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Inhibition of the proton-activated chloride channel PAC by PIP2 [PDF]
eLife, 2023 Proton-activated chloride (PAC) channel is a ubiquitously expressed pH-sensing ion channel, encoded by PACC1 (TMEM206). PAC regulates endosomal acidification and macropinosome shrinkage by releasing chloride from the organelle lumens. It is also found at
Ljubica Mihaljević +4 more
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ClC-1 Chloride Channel: Inputs on the Structure–Function Relationship of Myotonia Congenita-Causing Mutations [PDF]
Biomedicines, 2023 Myotonia congenita is a hereditary muscle disease mainly characterized by muscle hyperexcitability, which leads to a sustained burst of discharges that correlates with the magnitude and duration of involuntary aftercontractions, muscle stiffness, and ...
Oscar Brenes +2 more
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Structure of the CLC-1 chloride channel from Homo sapiens [PDF]
eLife, 2018 CLC channels mediate passive Cl− conduction, while CLC transporters mediate active Cl− transport coupled to H+ transport in the opposite direction. The distinction between CLC-0/1/2 channels and CLC transporters seems undetectable by amino acid sequence.
Eunyong Park, Roderick MacKinnon
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Chloride channels regulate differentiation and barrier functions of the mammalian airway [PDF]
eLife, 2020 The conducting airway forms a protective mucosal barrier and is the primary target of airway disorders. The molecular events required for the formation and function of the airway mucosal barrier, as well as the mechanisms by which barrier dysfunction ...
Mu He +14 more
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Molecular mechanism underlying desensitization of the proton-activated chloride channel PAC [PDF]
eLife, 2022 Desensitization is a common property of membrane receptors, including ion channels. The newly identified proton-activated chloride (PAC) channel plays an important role in regulating the pH and size of organelles in the endocytic pathway, and is also ...
James Osei-Owusu +6 more
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Frontiers in Plant Science, 2022 Nitrate accumulation in tobacco (Nicotiana tabacum L.) leaf, particularly in the burley (BU) type, is a reservoir for the generation of nitrosating agents responsible for the formation of tobacco-specific nitrosamines (TSNAs).
Lucien Bovet +11 more
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Frontiers in Neuroscience, 2021 AimGtACR2, a light-activated chloride channel, is an attractive tool for neural inhibition as it can shunt membrane depolarizations. In this study, we assessed the effect of activating GtACR2 on in vivo hippocampal CA1 activity evoked by Schaffer ...
Anirudh R. Acharya +8 more
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Proton-Activated Chloride Channel: Physiology and Disease
Frontiers in Bioscience-Landmark, 2023 The maintenance of intracellular and extracellular pH relies on multiple ion transporters/channels. Proton-activated chloride channel (PAC) precisely regulates extracellular and early/late endosomal pH by transporting chloride ion (Cl-) across membranes ...
Fanglin Peng +3 more
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Osmoregulated Chloride Currents in Hemocytes from Mytilus galloprovincialis. [PDF]
PLoS ONE, 2016 We investigated the biophysical properties of the transport mediated by ion channels in hemocytes from the hemolymph of the bivalve Mytilus galloprovincialis.
Monica Bregante +6 more
doaj +1 more source