Quantitative description of ion transport via plasma membrane of yeast and small cells [PDF]
, 2015 Modeling of ion transport via plasma membrane needs identification and quantitative understanding of the involved processes. Brief characterization of main ion transport systems of a yeast cell (Pma1, Ena1, TOK1, Nha1, Trk1, Trk2, non-selective cation ...
Volkov, Vadim
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The essential roles of metal ions in insect homeostasis and physiology [PDF]
, 2017 Metal ions play distinct roles in living organisms, including insects. Some, like sodium and potassium, are central players in osmoregulation and ‘blood and guts’ transport physiology, and have been implicated in cold adaptation.
Dow, Julian A.T.
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Intravital imaging reveals p53-dependent cancer cell death induced by phototherapy via calcium signaling. [PDF]
, 2014 One challenge in biology is signal transduction monitoring in a physiological context. Intravital imaging techniques are revolutionizing our understanding of tumor and host cell behaviors in the tumor environment.
Bonora, M +9 more
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Modulator Therapy for Cystic Fibrosis: An Exploration of Current Research [PDF]
, 2020 Developing a drug therapy that addresses the root cause of cystic fibrosis (CF) by increasing CFTR protein levels has long been a research challenge. After genetic therapy failed because a suitable delivery system could not be found, researchers began ...
Rombocos, Jessalyn
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Mechanisms of endothelial cell dysfunction in cystic fibrosis [PDF]
, 2017 Although cystic fibrosis (CF) patients exhibit signs of endothelial perturbation, the functions of the cystic fibrosis conductance regulator (CFTR) in vascular endothelial cells (EC) are poorly defined.
Anile, Marco +22 more
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Chloride homeostasis and GABA signaling in temporal lobe epilepsy [PDF]
Epilepsia, 2010 SummaryTwo electron‐neutral, cation‐chloride cotransporters control intraneuronal chloride ion concentration (Cl−). The Na‐K‐2Cl cotransporter‐1 mediates Cl− influx while the K‐Cl cotransporter‐2 (KCC2) extrudes Cl−, assuring that γ‐aminobutyric acid (GABA)ergic signals hyperpolarize neurons. KCC2 is downregulated in pyramidal cells from human temporal
Kai Kaila, Richard Miles
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Bistable dynamics underlying excitability of ion homeostasis in neuron models
, 2014 When neurons fire action potentials, dissipation of free energy is usually not directly considered, because the change in free energy is often negligible compared to the immense reservoir stored in neural transmembrane ion gradients and the long-term ...
Dahlem, Markus A. +2 more
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Subchronic dietary exposure of rats to cadmium alters the metabolism of metals essential to bone health [PDF]
, 2004 Cadmium (Cd) was recently identified as a risk factor for osteoporosis. Skeletal damage may be the critical effect of low-level long-term exposure to Cd in the general population exposed via food, but the mechanisms behind this are not clearly understood.
Guérin, Thierry +2 more
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Vesicular CLC chloride/proton exchangers in health and diseases
Frontiers in Pharmacology, 2023 Chloride is one of the most abundant anions in the human body; it is implicated in several physiological processes such as the transmission of action potentials, transepithelial salt transport, maintenance of cellular homeostasis, regulation of osmotic ...
Alessandra Picollo, Alessandra Picollo
doaj +1 more source
Chloride channels regulate differentiation and barrier functions of the mammalian airway. [PDF]
, 2020 The conducting airway forms a protective mucosal barrier and is the primary target of airway disorders. The molecular events required for the formation and function of the airway mucosal barrier, as well as the mechanisms by which barrier dysfunction ...
Caplan, Michael J +14 more
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