Results 61 to 70 of about 839,045 (255)

Regulation of osmoadaptation in the moderate halophile Halobacillus halophilus : chloride, glutamate and switching osmolyte strategies [PDF]

, 2008
The moderate halophile Halobacillus halophilus is the paradigm for chloride dependent growth in prokaryotes. Recent experiments shed light on the molecular basis of the chloride dependence that is reviewed here.
Saum, Stephan H., Müller, Volker
core   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Uncovering novel KCC2 regulatory motifs through a comprehensive transposon-based mutant library

Frontiers in Molecular Neuroscience
IntroductionThe neuron-specific K-Cl cotransporter KCC2 maintains low intracellular chloride levels, which are crucial for fast GABAergic and glycinergic neurotransmission.
Pavel Uvarov, Satoshi Fudo, Cem Karakus, Andrey Golubtsov, Federico Rotondo, Tatiana Sukhanova, Shetal Soni, Coralie Di Scala, Coralie Di Scala, Tommi Kajander, Claudio Rivera, Claudio Rivera, Anastasia Ludwig   +12 more
doaj   +1 more source

The adipocyte hormone leptin sets the emergence of hippocampal inhibition in mice

eLife, 2018
Brain computations rely on a proper balance between excitation and inhibition which progressively emerges during postnatal development in rodent. γ-Aminobutyric acid (GABA) neurotransmission supports inhibition in the adult brain but excites immature ...
Camille Dumon, Diabe Diabira, Ilona Chudotvorova, Francesca Bader, Semra Sahin, Jinwei Zhang, Christophe Porcher, Gary Wayman, Igor Medina, Jean-Luc Gaiarsa   +9 more
doaj   +1 more source

Integrative concept of homeostasis: translating physiology into medicine [PDF]

, 2011
To truly understand living systems they must be viewed as a whole. In order to achieve this and to come to some law to which living systems obey, data obtained on cells, tissues and organs should be integrated.
Ivan Spasojevic
core   +1 more source

A Multifunctional Ionograsper Enabling Ion‐Redistribution Proximity Sensing and Structural‐Reconfiguration‐Driven Bidirectional Actuation

Advanced Materials, EarlyView.
A solid‐state ionic actuator integrates sensing, actuation, and memory within one material. A brief UV pulse induces long‐lasting deformation via coupled network rearrangement, dehydration, and rehydration, while ionic redistribution enables self‐powered sensing, supporting multifunctional, energy‐efficient soft robotic functions without continuous ...
Yong Min Kim, Jin Han Kwon, Hyeon Woo Yang, Sungryong Kim, Gyeong Rok Lee, Hong Chul Moon   +5 more
wiley   +1 more source

The role of KCC2 and NKCC1 in spinal cord injury: From physiology to pathology

Frontiers in Physiology, 2022
The balance of ion concentrations inside and outside the cell is an essential homeostatic mechanism in neurons and serves as the basis for a variety of physiological activities.
Zuliyaer Talifu, Zuliyaer Talifu, Zuliyaer Talifu, Zuliyaer Talifu, Zuliyaer Talifu, Zuliyaer Talifu, Yunzhu Pan, Yunzhu Pan, Yunzhu Pan, Yunzhu Pan, Yunzhu Pan, Yunzhu Pan, Han Gong, Han Gong, Han Gong, Han Gong, Han Gong, Xin Xu, Xin Xu, Xin Xu, Xin Xu, Xin Xu, Chunjia Zhang, Chunjia Zhang, Chunjia Zhang, Chunjia Zhang, Chunjia Zhang, Degang Yang, Degang Yang, Degang Yang, Degang Yang, Feng Gao, Feng Gao, Feng Gao, Feng Gao, Yan Yu, Yan Yu, Yan Yu, Yan Yu, Liangjie Du, Liangjie Du, Liangjie Du, Liangjie Du, Jianjun Li, Jianjun Li, Jianjun Li, Jianjun Li, Jianjun Li, Jianjun Li   +48 more
doaj   +1 more source

3D‐Printed Corneal Substitutes: Materials, Fabrication, and Preclinical Progress

Advanced Materials Technologies, EarlyView.
Successful clinical translation of 3D‐printed corneal substitutes relies on the interplay between the bioink properties, cellular component, and the fabrication process. These factors influence the critical properties of the construct, including optical transparency, mechanical stability, suture retention, that ultimately govern long‐term stromal ...
Shadi Moshayedi, Ashley Vazquez, Alexander J. Choi, Dimitrios Karamichos, Jayoung Kim   +4 more
wiley   +1 more source

An investigation into the relationship between surface concrete resistivity and chloride conductivity test [PDF]

, 2014
Includes bibliographical references.The chloride conductivity test (CCT) is a South African-developed Durability Index (DI) test used for the evaluation and quantification of the quality of concrete cover.
Mutale, Lombe
core   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source