Results 71 to 80 of about 296,529 (174)

Cryo-EM structure of the potassium-chloride cotransporter KCC4 in lipid nanodiscs. [PDF]

, 2020
Cation-chloride-cotransporters (CCCs) catalyze transport of Cl- with K+ and/or Na+across cellular membranes. CCCs play roles in cellular volume regulation, neural development and function, audition, regulation of blood pressure, and renal function.
Brohawn, Stephen Graf, Kern, David M, Reid, Michelle S   +2 more
core   +2 more sources

Development of the Chloride Homeostasis in the Auditory Brainstem

Physiological Research, 2011
Inhibitory neurotransmission plays a substantial role in encoding of auditory cues relevant for sound localization in vertebrates. While the anatomical organization of the respective afferent auditory brainstem circuits shows remarkable similarities between mammals and birds, the properties of inhibitory neurotransmission in these neural circuits are ...
I, Milenković, R, Rübsamen
openaire   +2 more sources

Refuting the challenges of the developmental shift of polarity of GABA actions: GABA more exciting than ever!

Frontiers in Cellular Neuroscience, 2012
During brain development, there is a progressive reduction of intracellular chloride associated with a shift in GABA polarity: GABA depolarizes and occasionally excites immature neurons, subsequently hyperpolarizing them at later stages of development ...
Yehezkel eBen-Ari, Melanie A Woodin, Evelyne eSernagor, Laura eCancedda, Laurent eVinay, Claudio eRivera, Pascal eLegendre, Heiko J Luhmann, Angelique eBordey, Peter eWenner, Atsuo eFukuda, Anthony N van den Pol, Jean-Luc eGaiarsa, Enrico eCherubini   +13 more
doaj   +1 more source

The role of KCC2 and NKCC1 in spinal cord injury: From physiology to pathology

Frontiers in Physiology, 2022
The balance of ion concentrations inside and outside the cell is an essential homeostatic mechanism in neurons and serves as the basis for a variety of physiological activities.
Zuliyaer Talifu, Zuliyaer Talifu, Zuliyaer Talifu, Zuliyaer Talifu, Zuliyaer Talifu, Zuliyaer Talifu, Yunzhu Pan, Yunzhu Pan, Yunzhu Pan, Yunzhu Pan, Yunzhu Pan, Yunzhu Pan, Han Gong, Han Gong, Han Gong, Han Gong, Han Gong, Xin Xu, Xin Xu, Xin Xu, Xin Xu, Xin Xu, Chunjia Zhang, Chunjia Zhang, Chunjia Zhang, Chunjia Zhang, Chunjia Zhang, Degang Yang, Degang Yang, Degang Yang, Degang Yang, Feng Gao, Feng Gao, Feng Gao, Feng Gao, Yan Yu, Yan Yu, Yan Yu, Yan Yu, Liangjie Du, Liangjie Du, Liangjie Du, Liangjie Du, Jianjun Li, Jianjun Li, Jianjun Li, Jianjun Li, Jianjun Li, Jianjun Li   +48 more
doaj   +1 more source

KCC2 phosphorylation dynamics relate to oligomerization during development and after spinal cord injury

Frontiers in Molecular Neuroscience
Effective synaptic inhibition relies on KCC2, a K+-Cl− cotransporter that forms oligomers to extrude chloride. However, how phosphorylation regulates oligomerization remains unclear.
Sylvie Liabeuf, Cecile Brocard, Jacques-Olivier Coq, Laurent Vinay, Frederic Brocard   +4 more
doaj   +1 more source

The NKCC1 antagonist bumetanide mitigates interneuronopathy associated with ethanol exposure in utero

eLife, 2019
Prenatal exposure to ethanol induces aberrant tangential migration of corticopetal GABAergic interneurons, and long-term alterations in the form and function of the prefrontal cortex.
Alexander GJ Skorput, Stephanie M Lee, Pamela WL Yeh, Hermes H Yeh   +3 more
doaj   +1 more source

Renal potassium handling in rats with subtotal nephrectomy: modeling and analysis [PDF]

, 2018
We sought to decipher the mechanisms underlying the kidney's response to changes in K+ load and intake, under physiological and pathophysiological conditions.
Edwards, Aurelie, Layton, Anita T., Vallon, Volker   +2 more
core   +1 more source

Uncovering novel KCC2 regulatory motifs through a comprehensive transposon-based mutant library

Frontiers in Molecular Neuroscience
IntroductionThe neuron-specific K-Cl cotransporter KCC2 maintains low intracellular chloride levels, which are crucial for fast GABAergic and glycinergic neurotransmission.
Pavel Uvarov, Satoshi Fudo, Cem Karakus, Andrey Golubtsov, Federico Rotondo, Tatiana Sukhanova, Shetal Soni, Coralie Di Scala, Coralie Di Scala, Tommi Kajander, Claudio Rivera, Claudio Rivera, Anastasia Ludwig   +12 more
doaj   +1 more source

The in vitro assessment of the bioavailability of iron in New Zealand beef : a thesis presented in partial fulfillment of the requirements for the degree of Master of Science in Physiology at Massey University, Palmerston North, New Zealand / [PDF]

, 2003
The bioavailability of iron in New Zealand beef either alone or as part of a 'typical' New Zealand meal was investigated. The solubility of iron and its in vitro absorption by mouse intestinal tissue were used to evaluate iron bioavailability.
Walker, Lisa Rochelle
core  

Ammonia toxicity: from head to toe? [PDF]

, 2016
Ammonia is diffused and transported across all plasma membranes. This entails that hyperammonemia leads to an increase in ammonia in all organs and tissues.
Dasarathy, Srinivasan, Mookerjee, Rajeshwar P., Ott, Peter, Rackayova, Veronika, Rangroo Thrane, Vinita, Rose, Christopher, Vairappan, Balasubramaniyan   +6 more
core   +1 more source