Results 81 to 90 of about 296,529 (174)
Role of the Cation-Chloride-Cotransporters in Cardiovascular Disease
Cells, 2020 The SLC12 family of cation-chloride-cotransporters (CCCs) is comprised of potassium chloride cotransporters (KCCs), which mediate Cl− extrusion and sodium-potassium chloride cotransporters (N[K]CCs), which mediate Cl− loading.
Nur Farah Meor Azlan, Jinwei Zhang
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Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90β. [PDF]
, 2016 Mutations in human CLC-1 chloride channel are associated with the skeletal muscle disorder myotonia congenita. The disease-causing mutant A531V manifests enhanced proteasomal degradation of CLC-1.
Chen, Shu-Ching +7 more
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Nature Communications, 2022 Osteoclast over-activation leads to bone loss and chloride homeostasis is important for osteoclast function. Here, the authors show that Anoctamin 1 controls bone resorption by coupling Cl− channel activation with RANKL-RANK signaling transduction.
Weijia Sun +21 more
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Serum Chloride and Heart Failure
Kidney Medicine, 2023 Despite significant advances in management, heart failure continues to impose a significant epidemiologic burden with high prevalence and mortality rates. For decades, sodium has been the serum electrolyte most commonly associated with outcomes; however,
Nayan Arora, MD
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Increased intestinal carbonate precipitate abundance in the sea bream (Sparus aurata L.) in response to ocean acidification [PDF]
, 2019 Marine fish contribute to the carbon cycle by producing mineralized intestinal precipitates generated as by-products of their osmoregulation. Here we aimed at characterizing the control of epithelial bicarbonate secretion and intestinal precipitate ...
Carvalho, Edison S. M. +3 more
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Chloride Homeostasis in Central Neurons
, 2016 The overall aim of the present thesis is to clarify the control of intracellular chloride homeostasis in central neurons, because of the critical role of chloride ions (Cl–) for neuronal function. Normal function of the central nervous system (CNS) depends on a delicate balance between neuronal excitation and inhibition.
openaire +2 more sources
The adipocyte hormone leptin sets the emergence of hippocampal inhibition in mice
eLife, 2018 Brain computations rely on a proper balance between excitation and inhibition which progressively emerges during postnatal development in rodent. γ-Aminobutyric acid (GABA) neurotransmission supports inhibition in the adult brain but excites immature ...
Camille Dumon +9 more
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Nature Communications, 2020 The human NKCC1 transporter belongs to the cation–chloride cotransporter (CCC) family and has important physiological functions, among them the regulation of chloride homeostasis and neuronal excitability.
Xiaoyong Yang, Qinzhe Wang, Erhu Cao
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An Unusual Combination of Neurological Manifestations and Sudden Vision Loss in a Child with Familial Hyperphosphatemic Tumoral Calcinosis [PDF]
, 2019 Hyperphosphatemia in the absence of renal failure is an unusual occurrence, particularly in children, but is a common primary feature of familial hyperphosphatemic tumor calcinosis.
Acton, Dena +7 more
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CO2-dependent opening of an inwardly rectifying K+ channel [PDF]
, 2011 CO2 chemosensing is a vital function for the maintenance of life that helps to control acid–base balance. Most studies have reported that CO2 is measured via its proxy, pH. Here we report an inwardly rectifying channel, in outside-out excised patches
Huckstepp, Robert T. R., Dale, Nicholas
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