Results 231 to 240 of about 24,401 (257)

Effects of phytochemicals on macrophage cholesterol efflux capacity: Impact on atherosclerosis

Phytotherapy Research, 2021
High‐density lipoprotein cholesterol (HDL) is the major promoter of reverse cholesterol transport and efflux of excess cellular cholesterol. The functions of HDL, such as cholesterol efflux, are associated with cardiovascular disease rather than HDL levels. We have reviewed the evidence base on the major classes of phytochemicals, including polyphenols,
Saba Soltani, Motahareh Boozari, Arrigo F G Cicero   +2 more
exaly   +3 more sources

Significance of the percentage of cholesterol efflux capacity and total cholesterol efflux capacity in patients with or without coronary artery disease

Heart and Vessels, 2016
We hypothesized that cholesterol efflux capacity is more useful than the lipid profile as a marker of the presence and the severity of coronary artery disease (CAD). Therefore, we investigated the associations between the presence and the severity of CAD and both the percentage of cholesterol efflux capacity and total cholesterol efflux capacity and ...
Kenji Norimatsu, Tomohiko Shimizu, Yuhei Shiga   +2 more
exaly   +3 more sources

HDL Cholesterol Efflux Capacity and Incident Cardiovascular Events [PDF]

New England Journal of Medicine, 2014
It is unclear whether high-density lipoprotein (HDL) cholesterol concentration plays a causal role in atherosclerosis. A more important factor may be HDL cholesterol efflux capacity, the ability of HDL to accept cholesterol from macrophages, which is a key step in reverse cholesterol transport.
Anand Rohatgi, Colby R Ayers, Ivan S Yuhanna   +2 more
exaly   +3 more sources

Cholesterol efflux capacity: An introduction for clinicians

American Heart Journal, 2016
Epidemiologic studies have shown an inverse correlation between high-density lipoprotein (HDL) cholesterol (HDL-C) levels and cardiovascular disease outcomes. However, the hypothesis of a causal relationship between HDL-C and cardiovascular disease has been challenged by genetic and clinical studies.
Malcolm, Anastasius, Maaike, Kockx, Wendy, Jessup, David, Sullivan, Kerry-Anne, Rye, Leonard, Kritharides   +5 more
openaire   +2 more sources

From HDL-cholesterol to HDL-function: cholesterol efflux capacity determinants

Current Opinion in Lipidology, 2019
Purpose of review The validity of HDL-cholesterol (HDL-C) elevation as a therapeutic target has been questioned, in comparison to enhancing HDL functionality. Cholesterol efflux capacity (CEC) is an in-vitro assay that measures the ability of an individual's HDL to promote cholesterol efflux from cholesterol donor cells such as
David, Rhainds, Jean-Claude, Tardif
openaire   +2 more sources

Modulating cholesterol efflux capacity to improve cardiovascular disease

Current Opinion in Lipidology, 2016
Purpose of review Low HDL-cholesterol (HDL-C) levels are predictive of incident atherosclerotic cardiovascular disease events. However, the use of medication to raise HDL-C levels has not consistently shown clinical benefit. As a result, studies have shifted toward HDL function, specifically cholesterol efflux, which has been ...
Nicholas, Brownell, Anand, Rohatgi
openaire   +2 more sources

Modulation of cholesterol efflux capacity in patients with myocardial infarction

Current Opinion in Cardiology, 2019
Epidemiologic studies consistently demonstrated that patients with coronary artery disease (CAD) and low HDL cholesterol (HDL-C) are more likely to develop major adverse cardiovascular events as compared with those with normal or high HDL. However, several large randomized trials failed to demonstrate that a substantial, pharmacological-based, increase
Silvain, Johanne, Kerneis, Mathieu, Guerin, Maryse, Montalescot, Gilles   +3 more
openaire   +2 more sources

Cholesterol efflux capacity in coronary artery disease: a meta-analysis

Coronary Artery Disease, 2020
Objective To quantitatively analyze the association between cholesterol efflux capacity (CEC) and the risk and prognosis of coronary artery disease (CAD). Methods A systematic search of electronic databases for studies published until September 2019 was performed.
Huiming, Ye, Guiyu, Xu, Lihui, Ren, Jianjun, Peng   +3 more
openaire   +2 more sources

A-230 Impact of Efflux Duration on Cholesterol Efflux Capacity in Cellular Assays

Clinical Chemistry
Abstract Background Cholesterol efflux capacity (CEC), a key anti-atherosclerotic function of high-density lipoprotein (HDL), plays a crucial role in preventing cardiovascular disease (CVD). HDL reduces lipid burden in atherosclerotic lesions via cholesterol efflux.
Hanae Akiyama, Tsunehiro Miyakoshi, Akira Yoshimoto, Mei Watanabe, Naoya Ichimura, Shuji Tohda, Ryunosuke Ohkawa   +6 more
openaire   +1 more source

Evaluation of serum cholesterol efflux capacity in diabetic compared to healthy subjects

Atherosclerosis, 2014
Objectives: HDL provide cardiovascular protection by promoting reverse cholesterol transport (RCT). Efflux of cell cholesterol to HDL, the first step of RCT, can occur through aqueous diffusion, SR-BI, ABCG1 and ABCA1. Serum cholesterol efflux capacity (CEC), an index of HDL functionality, depends of HDL levels but is also strictly related to HDL ...
Adorni, MP, Favari, E, Ronda, N, Zimetti, F, Ardigò, D, Franzini, L, Manfredini, M, Calandra, S, Cicero, AFG, Vigna, GB, Zavaroni, I, Bernini, F   +11 more
openaire   +1 more source