Results 41 to 50 of about 5,014,718 (261)

Cholic Acid Biosynthesis [PDF]

Journal of Clinical Investigation, 1979
Cholic acid biosynthesis is defective in individuals with cerebrotendinous xanthomatosis (CTX) and is associated with the excretion of 5beta-cholestane-3alpha,7alpha, 12alpha,25-tetrol, an intermediate in the 25-hydroxylation pathway of cholic acid in CTX.
B. Dayal, F W Cheng, S Shefer, G.S. Tint, Ashok K. Batta, Gerald Salen   +5 more
openaire   +3 more sources

Alterations and mechanistic insights of gut microbiota and its metabolites in type 2 diabetes mellitus and Alzheimer's disease

iMetaOmics, EarlyView.
This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu, Yu An, Yage Du, Zhaoming Cao, Jie Zheng, Jingya Wang, Tingyi Li, Xingen Lei, Yanhui Lu   +8 more
wiley   +1 more source

Mechanism of intestinal formation of deoxycholic acid from cholic acid in humans: evidence for a 3-oxo-delta 4-steroid intermediate.

Journal of Lipid Research, 1989
12 alpha-Hydroxy-3-oxo-4-cholenoic acid coupled to an adenosine nucleotide has been shown to be a metabolite of cholic acid in the intestinal anaerobic bacteria, Eubacterium species VPI 12708 (1987. J. Biol. Chem.
I Björkhem, K Einarsson, P Melone, P Hylemon   +3 more
doaj  

Block and Random Copolymers Bearing Cholic Acid and Oligo(ethylene glycol) Pendant Groups: Aggregation, Thermosensitivity, and Drug Loading

Biomacromolecules, 2014
A series of block and random copolymers consisting of oligo(ethylene glycol) and cholic acid pendant groups were synthesized via ring-opening metathesis polymerization of their norbornene derivatives.
Yu Shao, Yongguang Jia, Changying Shi, Juntao Luo, X. X. Zhu   +4 more
semanticscholar   +1 more source

A gut microbiota‐bile acid axis inhibits the infection of an emerging coronavirus by targeting its cellular receptor aminopeptidase N

iMeta, EarlyView.
Bacteroides fragilis employs bile salt hydrolase to reprogram host bile acid metabolism, generating lithocholic acid that directly blocks porcine deltacoronavirus infection by disrupting spike protein‐aminopeptidase N binding, defining a microbiota‐bile acid antiviral axis with therapeutic potential against coronaviruses.
Ya‐Qing Zhang, Bin Wang, Yong‐Le Yang, Jin‐Xin Meng, Meng‐Di Zhang, Yi‐Ke Li, Bo Dong, Yanan Zhang, Bo‐Wen Liu, Dong Yang, Chun‐Miao Ji, Yao‐Wei Huang, Shu Jeffrey Zhu   +12 more
wiley   +1 more source

7alpha-Dehydroxylation of cholic acid and chenodeoxycholic acid by Clostridium leptum.

Journal of Lipid Research, 1979
The rate of 7alpha-dehydroxylation of primary bile acids was quantitatively measured radiochromatographically in anaerobically washed whole cell suspensions of Clostridium leptum.
E J Stellwag, P B Hylemon
doaj  

Study on the mechanism of cholic acid derivatives in traditional Chinese medicine based on the regulation of gene expression

Journal of Traditional Chinese Medical Sciences, 2023
Objective: To investigate the pharmacological action and mechanism of cholic acid derivatives in traditional Chinese medicine (TCM) based on the regulation of gene expression. Methods: Genome-wide gene expression profiles of Michigan Cancer Foundation-7 (
Yongchun Huang, Jie Zhang, Pengxiang Zhao, Yufeng Ma, Qiangqiang Jia, Shoude Zhang   +5 more
doaj  

Exogenous oxidized phytosterol may modulate linoleic acid metabolism through upregulation of fatty acid desaturase in rats

Lipids, EarlyView.
Abstract Previous in vitro studies have indicated that oxidized phytosterol (OPS) exhibits some toxicity; however, the harmful effects of OPS on fatty acid metabolism are not completely understood yet. Therefore, this study examined the effects of exogenous phytosterol (PS) and OPS on growth parameters and lipid metabolism in rats.
Tomonari Koyama, Kyoichi Osada
wiley   +1 more source

Oral Delivery of Ellagic Acid Encapsulated in Milk Exosomes: Sex‐Based Differences in Bioavailability, Urolithin Production, and Gut Microbiota Modulation

Molecular Nutrition &Food Research, EarlyView.
Sex‐dependent effects on plasma metabolome and gut microbiota were observed after oral administration of ellagic acid (EA) encapsulated in milk‐derived exosomes (EXO‐EA) versus non‐encapsulated EA (NEA) and non‐loaded EXOs. EXO‐EA impacted plasma metabolome, modulated gut microbiota, and increased urolithin A and SCFA production sex‐dependently ...
María Ángeles Ávila‐Gálvez, María Romo‐Vaquero, Carmen Mazarío‐Gárgoles, Joao Tomé‐Carneiro, María‐Carmen López de las Hazas, Alberto Dávalos, María Victoria Selma, Antonio González‐Sarrías, Juan Carlos Espín   +8 more
wiley   +1 more source

The metabolism of 3α, 7α, 12α-trihydroxy-5β-cholestan-26-oic acid into cholic: an enzyme assay using homogenates of human liver

Journal of Lipid Research, 1976
An enzyme assay was developed to measure the conversion of the bile acid precursor, 3α, 7α, 12α-trihydroxy-5β-cholestan-26-oic acid (THCA), into cholic acid using homogenates of human liver biopsies.
R F Hanson, H L Sharp, G C Williams
doaj