Results 41 to 50 of about 5,133,102 (254)

The metabolism of 3α, 7α, 12α-trihydroxy-5β-cholestan-26-oic acid into cholic: an enzyme assay using homogenates of human liver

Journal of Lipid Research, 1976
An enzyme assay was developed to measure the conversion of the bile acid precursor, 3α, 7α, 12α-trihydroxy-5β-cholestan-26-oic acid (THCA), into cholic acid using homogenates of human liver biopsies.
R F Hanson, H L Sharp, G C Williams
doaj   +1 more source

Evidence for a lack of regulatory importance of the 12 alpha-hydroxylase in formation of bile acids in man: an in vivo study.

Journal of Lipid Research, 1983
The possibility that the 12 alpha-hydroxylase involved in formation of bile acids is of regulatory importance for the ratio between cholic acid and chenodeoxycholic acid in bile was studied with an in vivo technique.
I Björkhem, M Eriksson, K Einarsson
doaj   +1 more source

Biophysical Elucidation of Amyloid Fibrillation Inhibition and Prevention of Secondary Nucleation by Cholic Acid: An Unexplored Function of Cholic Acid.

ACS Chemical Neuroscience, 2019
Protein misfolding and its deviant self-assembly to converge into amyloid fibrils is associated with the perturbation of cellular functions and thus with debilitating neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, etc.
Nabeela Majid, M. Siddiqi, Asra Nasir Khan, Shabnam Shabnam, S. Malik, A. Alam, V. Uversky, R. H. Khan   +7 more
semanticscholar   +1 more source

Physiological characteristics of allo-cholic acid [PDF]

Journal of Lipid Research, 2003
The physiological characterstics of allo-cholic acid (ACA), a typically fetal bile acid that reappears during liver regeneration and carcinogenesis were investigated. [(14)C] Tauro-ACA (TACA) uptake by Chinese hamster ovary cells expressing rat organic anion transporter polypeptide (Oatp)1 or sodium-taurocholate cotransporter polypeptide (Ntcp) was ...
Mendoza, Maria E., Monte, Maria J., Serrano, Maria A., Pastor-Anglada, Marçal, Stieger, Bruno, Meier, Peter J., Medarde, Manuel, Marin, Jose J. G.   +7 more
openaire   +6 more sources

Oral Delivery of Cholic Acid-Derived Amphiphile Helps in Combating Salmonella-Mediated Gut Infection and Inflammation.

Bioconjugate chemistry, 2019
A major impediment to developing effective antimicrobials against Gram-negative bacteria like Salmonella is the ability of the bacteria to develop resistance against existing antibiotics and the inability of the antimicrobials to clear the intracellular ...
K. Yadav, P. Yavvari, S. Pal, Sandeep Kumar, Deepakkumar Mishra, Siddhi Gupta, Madhurima Mitra, V. Soni, Neha Khare, Priyanka Sharma, C. Srikanth, A. Kapil, Archana Singh, V. Nandicoori, Avinash Bajaj   +14 more
semanticscholar   +1 more source

Oxidoreduction of different hydroxyl groups in bile acids during their enterohepatic circulation in man.

Journal of Lipid Research, 1986
The extent of oxidoreduction of the 3 alpha-, 7 alpha- and 12 alpha-hydroxyl groups in bile acids during the enterohepatic circulation in man was studied with the use of [3 beta-3H]-labeled deoxycholic acid and cholic acid, [7 beta-3H]-labeled cholic ...
I Björkhem, L Liljeqvist, K Nilsell, K Einarsson   +3 more
doaj   +1 more source

An in vivo evaluation of the quantitative significance of several potential pathways to cholic and chenodeoxycholic acids from cholesterol in man

Journal of Lipid Research, 1980
The present study was designed to obtain more definitive information in man on the metabolic pathways to chenodeoxycholic acid and to cholic acid via a pathway not involving an initial 7 alpha-hydroxylation of cholesterol. Four bile fistula patients were
L Swell, J Gustafsson, C C Schwartz, L G Halloran, H Danielsson, Z R Vlahcevic   +5 more
doaj   +1 more source

Cholic acid for primary bile acid synthesis defects: a life-saving therapy allowing a favorable outcome in adulthood

Orphanet Journal of Rare Diseases, 2018
BackgroundOral cholic acid (CA) replacement has been shown to be an effective therapy in children with primary bile acid synthesis defects, which are rare and severe genetic liver diseases.
E. Gonzales, L. Matarazzo, S. Franchi-Abella, A. Dabadie, Joseph Cohen, D. Habès, S. Hillaire, C. Guettier, A. Taburet, A. Myara, E. Jacquemin   +10 more
semanticscholar   +1 more source

Human hepatoblastoma cells (HepG2) and rat hepatoma cells are defective in important enzyme activities in the oxidation of the C27 steroid side chain in bile acid formation

Journal of Lipid Research, 1993
We have examined the ability of HepG2 human hepatoblastoma cells and 7800 C1 Morris rat hepatoma cells to convert 3 alpha, 7 alpha, 12 alpha-trihydroxy-5 beta-cholestanoic acid (THCA) and 3 alpha, 7 alpha-dihydroxy-5 beta-cholestanoic acid (DHCA) to ...
Ann-Kristin Östlund Farrants, Astrid Nilsson, Jan I. Pedersen   +2 more
doaj   +1 more source

Oral Cholic Acid Is Efficacious and Well Tolerated in Patients With Bile Acid Synthesis and Zellweger Spectrum Disorders

Journal of Pediatric Gastroenterology and Nutrition - JPGN, 2017
Objectives: Patients with bile acid synthesis disorders (BASDs) due to single enzyme defects (SEDs) or Zellweger spectrum disorders (ZSDs) accumulate hepatotoxic atypical bile acids resulting in potentially fatal progressive liver disease.
J. Heubi, K. Bove, K. Setchell
semanticscholar   +1 more source