Results 71 to 80 of about 5,014,718 (261)

Weight Loss‐Associated Remodeling of Adipose Tissue Immunometabolism

Obesity Reviews, EarlyView.
ABSTRACT Obesity is a multifactorial condition characterized by excessive adiposity and systemic chronic low‐grade inflammation. Recent literature reflects a growing appreciation for the complex interplay between metabolism and the immune system in the pathogenesis of obesity‐related health conditions.
Paulo José Basso, Alejandro Schcolnik‐Cabrera, Mengyi Zhu, Erin Strachan, Xavier Clemente‐Casares, Sue Tsai   +5 more
wiley   +1 more source

Competitive inhibition of side chain oxidation of 3 alpha, 7 alpha-dihydroxy-5 beta-cholestan-26-oic acid by 3 alpha, 7 alpha, 12 alpha-trihydroxy-5 beta-cholestan-26-oic acid in the hamster.

Journal of Lipid Research, 1980
3 alpha,7 alpha-dihydroxy-5 beta-cholestan-26-oic acid (DHCA) and 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestan-26-oic acid (THCA) are metabolized into chenodeoxycholic acid and cholic acid, respectively, through oxidation and cleavage of the ...
O W Cass, G C Williams, R F Hanson
doaj  

Impacts of Vincristine and Prednisolone Chemotherapy on the Canine Gut Microbiota in Dogs Undergoing Treatment for Lymphoma

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Chemotherapy can have adverse gastrointestinal effects in dogs and people. The objective of this study was to assess the impact of vincristine and prednisolone/prednisone, as part of a CHOP chemotherapy [cyclophosphamide, hydroxydaunorubicin, oncovin (vincristine) and prednisolone/prednisone] protocol, on gastrointestinal dysbiosis in dogs ...
Juan Aragon, Annika M. Weber, Madison Tipton, Jennifer Thomsen, Hend Ibrahim, Kristen Weishaar, Sangeeta Rao, Jan S. Suchodolski, Jonathan Stockman, Elizabeth P. Ryan, Nora Jean Nealon   +10 more
wiley   +1 more source

Validation of [22,23-3H]cholic acid as a stable tracer through conversion to deoxycholic acid in human subjects

Journal of Lipid Research, 1996
Bile acids labeled with 3H on the sterol nucleus lose a substantial fraction of label during enterohepatic cycling and conversion to secondary bile acids. We tested the isotopic stability of a side-chain 3H label, [22,23-3H]cholic acid in humans.
W C Duane, C D Schteingart, H T Ton-Nu, A F Hofmann   +3 more
doaj  

On the action of nitric acid upon cholic acid [PDF]

The London, Edinburgh, and Dublin Philosophical Magazine and Journal of Science
(1846). On the action of nitric acid upon cholic acid. The London, Edinburgh, and Dublin Philosophical Magazine and Journal of Science: Vol. 29, No. 194, pp. 330-331.
openaire   +3 more sources

The mood stabilizers lithium and valproate disrupt hepatic and intestinal farnesoid X receptor signalling and increase bile synthesis in the rat

Experimental Physiology, EarlyView.
Abstract The mood stabilizers lithium and valproate are psychotropic medications widely used in clinical practice. Despite their proven benefits, many individuals stop their treatment due to the adverse effects. Chronic diarrhoea is a common reason for discontinuation of these drugs; however, the underlying mechanisms are unknown.
Sofia Cussotto, Anna V. Golubeva, Alvaro Lopez Gallardo, Thomaz F. S. Bastiaanssen, Alexander V. Zhdanov, Gerard M. Moloney, Caitriona Scaife, Jane A. English, Susan A. Joyce, Timothy G. Dinan, John F. Cryan   +10 more
wiley   +1 more source

Sex differences in gallbladder bile acid composition and hepatic steroid 12 alpha-hydroxylase activity in hamsters.

Journal of Lipid Research, 1983
The gallbladder bile acid composition and the activity of the hepatic steroid 12 alpha-hydroxylase were determined in male and female hamsters. Cholic acid, chenodeoxycholic acid, and deoxycholic acid were the major bile acids in both sexes; in addition,
S Kuroki, S Muramoto, T Kuramoto, T Hoshita   +3 more
doaj  

Atypical clinical presentation and successful treatment with oral cholic acid of a child with defective bile acid synthesis due to a novel mutation in the HSD3B7 gene

Pediatric Reports, 2017
We report definitive diagnosis and effective treatment with oral cholic acid in one Italian male child affected by 3β- hydroxy-Δ5-C27-steroid dehydrogenase (3β- HSD) deficiency. He presented with failure to thrive, hepatomegaly and multiple cystic images
Grazia Bossi, Giuseppe Giordano, Gaetana Anna Rispoli, Giuseppe Maggiore, Mauro Naturale, Daniela Marchetti, Maria Iascone   +6 more
doaj   +1 more source

Applying sterols and bile acids as biomarkers for identifying human versus wild animals' faecal traces in cave sediments at archaeological sites

Archaeometry, Volume 67, Issue 4, Page 1022-1039, August 2025.
Abstract Faecal biomarkers are used to trace and identify the source of faecal matter at various types of archaeological sites. Until now, the focus has been centred on humans and domesticated animals. However, in caves, it's wild animals that play a role in the deposition of organic matter.
Natalia Gryczewska, Marcin Sulwiński, Piotr Chibowski, Maciej T. Krajcarz, Marcin Zegarek, Małgorzata Kot, Andrea Pereswiet‐Soltan, Karol Szymczak, Małgorzata Suska‐Malawska   +8 more
wiley   +1 more source

Bile acid synthesis in HepG2 cells: effect of cyclosporin

Journal of Lipid Research, 1994
The hypothesis that cyclosporin specifically affects the pathway of bile acid synthesis that begins with 27-hydroxylation of cholesterol was evaluated in HepG2 cells, which synthesize chenodeoxycholic acid and cholic acid from endogenous 7 alpha ...
J Levy, K Budai, N B Javitt
doaj