Results 11 to 20 of about 48,102 (276)

Decrease of erythrocyte cholinesterase in pesticide factory workers [PDF]

مجله دانشگاه علوم پزشکی گرگان, 2007
Background&Objective: Two enzymes have the ability to hydrolyze acetylcholine. One is acetylcholinesterase, which is called true cholinesterase, it is found in erythrocytes. The other cholinesterase is pseudocholinesterase, it is found in serum.
Joshaghani HR, Ahmadi AR, Behnampour N
doaj   +1 more source

CHOLINESTERASE INHIBITORS: A LITERATURE REVIEW OF MEDICATION EFFICACY AND SAFETY FOR ALZHEIMER'S DISEASE [PDF]

, 2021
Background: With a steady increase of seniors in Canada’s overall population, geriatric-associated illnesses such as Alzheimer’s disease (AD) will continue to rise. AD is a progressive neurodegenerative disorder that causes plaque build-up in the brain
Wicklund, Ashley
core   +1 more source

Plant Terpenoids as the Promising Source of Cholinesterase Inhibitors for Anti-AD Therapy

Biology, 2022
Plant-derived terpenes are the prolific source of modern drugs such as taxol, chloroquine and artemisinin, which are widely used to treat cancer and malaria infections.
Shereen Lai Shi Min, Sook Yee Liew, Nelson Jeng Yeou Chear, Bey Hing Goh, Wen-Nee Tan, Kooi Yeong Khaw   +5 more
doaj   +1 more source

In Vitro Enzymatic and Kinetic Studies, and In Silico Drug-Receptor Interactions, and Drug-Like Profiling of the 5-Styrylbenzamide Derivatives as Potential Cholinesterase and β-Secretase Inhibitors with Antioxidant Properties

Antioxidants, 2021
The 5-(styryl)anthranilamides were transformed into the corresponding 5-styryl-2-(p-tolylsulfonamido)benzamide derivatives. These 5-styrylbenzamide derivatives were evaluated through enzymatic assays in vitro for their capability to inhibit ...
Malose J. Mphahlele, Emmanuel N. Agbo, Garland K. More, Samantha Gildenhuys   +3 more
doaj   +1 more source

Assessment of serum level cholinesterase as a biomarker of liver cirrhosis in Egyptian cirrhotic patients

Gastroenterology Insights, 2017
Serum cholinesterase levels are closely correlated with the severity of liver disease. The aim of the paper was to assess the value of serum cholinesterase in evaluating liver reserve function in cirrhotic patients.
Mona A. Amin, Marwa E. El-Shahat, Nouman El-Garem, Ahmed Soliman, Eman Obaia   +4 more
doaj   +1 more source

Evaluation of Cholinesterase Activities During in Vivo Intoxication Using an Electrochemical Sensor Strip – Correlation With Intoxication Symptoms

Sensors, 2009
Cholinesterase activity in blood of laboratory rats was monitored. Rats were intoxicated with paraoxon at dosis of 0 – 65 – 125 – 170 – 250 – 500 nmol. The 250 nmol dose was found to be the LD50.
Jana Zdarova-Karasova, Martina Hrabinova, Kamil Kuca, Ladislav Novotný, Jan Misík, Miroslav Pohanka   +5 more
doaj   +1 more source

Evaluation of Toxic Effects Induced by Sub-Acute Exposure to Low Doses of α-Cypermethrin in Adult Male Rats

Toxics, 2022
To contribute new information to the pyrethroid pesticide α-cypermethrin toxicity profile, we evaluated its effects after oral administration to Wistar rats at daily doses of 2.186, 0.015, 0.157, and 0.786 mg/kg bw for 28 days. Evaluations were performed
Vilena Kašuba, Blanka Tariba Lovaković, Ana Lucić Vrdoljak, Anja Katić, Nevenka Kopjar, Vedran Micek, Mirta Milić, Alica Pizent, Davor Želježić, Suzana Žunec   +9 more
doaj   +1 more source

Impact of cholinesterase inhibitors on behavioural and psychological symptoms of Alzheimer's disease: A meta-analysis [PDF]

, 2008
Noll Campbell1, Amir Ayub2, Malaz A Boustani2, Chris Fox3, Martin Farlow4, Ian Maidment3, Robert Howard51Wishard Health Services, Indianapolis, Indiana; 2Indiana University Center for Aging Research, Regenstrief Institute, Inc., Indianapolis, Indiana ...
Campbell, Noll, Boustani, Malaz A., Fox, Chris, Amir Ayub, Ayub, Amir, Martin Farlow, Howards, Robert, Howard, Robert, Noll Campbell, et al, Farlow, Martin, Chris Fox, Maidment, Ian, Malaz A Boustani   +13 more
core   +2 more sources

Molecular Basis for Activation to Inhibition Switching in Kv7.2 Channel Modulators

Angewandte Chemie, EarlyView.
The paper describes the serendipitous discovery of chemical manipulation allowing the activator‐to‐inhibitor switching in Kv7.2 channel modulators. The molecular determinants driving this switch have been rationalized by multidisciplinary investigation encompassing synthetic and analytical chemistry, in silico methods, cryo‐EM analysis ...
Tania Ciaglia, Giusy Carleo, Zhenni Yang, Francesca Di Matteo, Federica De Rosa, Gerardina Smaldone, Zhao‐Bing Gao, Marco D'Alì, Rita Turcio, Demin Ma, Veronica Di Sarno, Nannan Su, Salvatore Vincenzo Giofrè, Giacomo Pepe, Pietro Campiglia, Alessia Bertamino, Francesco Miceli, Jiangtao Guo, Nunzio Iraci, Carmine Ostacolo, Maurizio Taglialatela   +20 more
wiley   +2 more sources

Evaluation of acetylcholine esterase activity in the blood of workers exposed [PDF]

Kirkuk Journal of Science, 2013
Introduction:Organophosphate and carbamate insecticides pose major environmental pollution problems and health hazards to people and animals. These insecticides inhibit cholinesterase (ChE) activity in the nervous tissues and neuromuscular junctions.
Aydin S. Ahmed
doaj   +1 more source