Results 31 to 40 of about 53,217 (270)

Prolonged cholinergic enrichment influences regional cortical activation in early Alzheimer's disease [PDF]

, 2008
Neuroimaging studies of cholinesterase inhibitor (ChEI) treatment in Alzheimer's disease (AD) indicate that the short and long term actions of ChEIs are dissimilar. fMRI studies of the ChEI rivastigmine have focused on its short term action.
Shanks, Michael F, Venneri, Annalena, McGeown, William J   +2 more
core   +3 more sources

Beneficiary Effect of Zinc Supplementation in Tuberculosis as Reflected by Serum Level of Diagnostic Biomolecules [PDF]

Indian Journal of Medical Biochemistry
Aim and objective: This author had indoctrinated a higher Mycobacterium tuberculosis (Mtb) origin serum superoxide dismutase (SOD), detectable Mtb origin serum glutamine synthetase (GS) and inhibited host origin serum cholinesterase (ChE) as diagnostics ...
Dipak Kumar Chattopadhyay
doaj   +1 more source

Benzobicyclo[3.2.1]octene Derivatives as a New Class of Cholinesterase Inhibitors

Molecules, 2020
A library of amine, oxime, ether, epoxy and acyl derivatives of the benzobicyclo[3.2.1]octene were synthesized and evaluated as inhibitors of both human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).
Tena Čadež, Ana Grgičević, Ramiza Ahmetović, Danijela Barić, Nikolina Maček Hrvat, Zrinka Kovarik, Irena Škorić   +6 more
doaj   +1 more source

Molecular Basis for Activation to Inhibition Switching in Kv7.2 Channel Modulators

Angewandte Chemie, EarlyView.
The paper describes the serendipitous discovery of chemical manipulation allowing the activator‐to‐inhibitor switching in Kv7.2 channel modulators. The molecular determinants driving this switch have been rationalized by multidisciplinary investigation encompassing synthetic and analytical chemistry, in silico methods, cryo‐EM analysis ...
Tania Ciaglia, Giusy Carleo, Zhenni Yang, Francesca Di Matteo, Federica De Rosa, Gerardina Smaldone, Zhao‐Bing Gao, Marco D'Alì, Rita Turcio, Demin Ma, Veronica Di Sarno, Nannan Su, Salvatore Vincenzo Giofrè, Giacomo Pepe, Pietro Campiglia, Alessia Bertamino, Francesco Miceli, Jiangtao Guo, Nunzio Iraci, Carmine Ostacolo, Maurizio Taglialatela   +20 more
wiley   +2 more sources

Plant-Derived Bioactive Compounds in the Management of Neurodegenerative Disorders: Challenges, Future Directions and Molecular Mechanisms Involved in Neuroprotection

Pharmaceutics, 2023
Neurodegenerative disorders encompass a wide range of pathological conditions caused by progressive damage to the neuronal cells and nervous-system connections, which primarily target neuronal dysfunction and result in problems with mobility, cognition ...
Shoaib Shoaib, Mohammad Azam Ansari, Adel Al Fatease, Awaji Y. Safhi, Umme Hani, Roshan Jahan, Mohammad N. Alomary, Mohd Nazam Ansari, Nabeel Ahmed, Shadma Wahab, Wasim Ahmad, Nabiha Yusuf, Najmul Islam   +12 more
doaj   +1 more source

Non-Neuronal Acetylcholinesterase Activity Shows Limited Utility for Early Detection of Sepsis

Biomedicines, 2023
(1) Background: Sepsis is a severe systemic inflammatory condition characterized by rapid clinical deterioration and organ dysfunction. The cholinergic system has been implicated in modulating the inflammatory response.
Aleksandar R. Zivkovic, Karsten Schmidt, Stefan Hofer, Thorsten Brenner, Markus A. Weigand, Sebastian O. Decker   +5 more
doaj   +1 more source

Impact of cholinesterase inhibitors on behavioural and psychological symptoms of Alzheimer's disease: A meta-analysis [PDF]

, 2008
Noll Campbell1, Amir Ayub2, Malaz A Boustani2, Chris Fox3, Martin Farlow4, Ian Maidment3, Robert Howard51Wishard Health Services, Indianapolis, Indiana; 2Indiana University Center for Aging Research, Regenstrief Institute, Inc., Indianapolis, Indiana ...
Campbell, Noll, Boustani, Malaz A., Fox, Chris, Amir Ayub, Ayub, Amir, Martin Farlow, Howards, Robert, Howard, Robert, Noll Campbell, et al, Farlow, Martin, Chris Fox, Maidment, Ian, Malaz A Boustani   +13 more
core   +1 more source

Molecular Multi-Target Approach for Human Acetylcholinesterase, Butyrylcholinesterase and β-Secretase 1: Next Generation for Alzheimer’s Disease Treatment

Pharmaceuticals, 2023
Alzheimer’s Disease (AD) is a neurodegenerative condition characterized by progressive memory loss and other affected cognitive functions.
Géssica Oliveira Mendes, Samuel Silva da Rocha Pita, Paulo Batista de Carvalho, Michel Pires da Silva, Alex Gutterres Taranto, Franco Henrique Andrade Leite   +5 more
doaj   +1 more source

Donepezil and Memantine for moderate-to-severe Alzheimer's disease [PDF]

, 2012
Background Clinical trials have shown the benefits of cholinesterase inhibitors for the treatment of mild-to-moderate Alzheimer’s disease. It is not known whether treatment benefits continue after the progression to moderate-to-severe disease ...
O'Brien, John, Roy Jones (3539210), Juszczak, E, R. Brown (3682735), Gray, R, Richard Gray (2619970), Ballard, C, Burns, Alistair; id_orcid, Adams, Jessica, Knapp, M, J. Adams (7579901), Knapp, Martin, Robert Hills (3685870), Baldwin, A, P. Passmore (7608800), Dening, Tom, Griffin, M, S. Banerjee (1503751), B. Sheehan (7608761), Jones, Roy, T. Dening (7608776), Craig Ritchie (3531092), Sheehan, Bart, McShane, R, Mary Griffin (3203010), Bentham, Peter, O'Brien, John, Bart Sheehan (3836236), McShane, Rupert, Brown, R, Clive Holmes (237359), Dening, T, Hughes, Alan, Robin Jacoby (89610), Jones, R., Holmes, C, Clive Ballard (89605), Jacoby, Robin, Phillips, Patrick, Alan Hughes (178653), Sube Banerjee (4464202), D. Findlay (7608779), McKeith, I, Martin Knapp (146158), Ritchie, C. W., A. Baldwin (7608767), Ritchie, Craig, P. Phillips (5239541), Barber, R, C. Katona (6059216), David Findlay (46833), Banerjee, S, P. Bentham (7589273), Juszczak, Ed, Peter Bentham (16155026), Ashley Baldwin (14422653), Cornelius Katona (15210), Brown, Richard, J. Lindesay (7635890), McKeith, Ian, Barber, Robert, Brown, Richard; id_orcid, E. Juszczak (7589267), Burns, A, Banerjee, Sube, Macharouthu, Ajay, Edmund Juszczak (89612), Passmore, P, Jones, R, James Lindesay (7582160), Gray, Richard, Phillips, P, R. Jacoby (7589288), J. O'Brien (7608797), Robert Barber (337950), Phillips, P., A. Burns (842688), Tom Dening (3097692), R. Howard (1274091), Juszczak, Edmund, Ian McKeith (369422), Patrick Phillips (1420741), C. Holmes (7589285), Peter Passmore (254593), M. Griffin (3933326), Macharouthu, A, M. Knapp (2534038), Rupert McShane (89609), C. Ballard (7608770), Passmore, Peter, Johnson, T, R. l. Barber (7635893), Robert Howard (190740), Hills, Robert Kerrin, Findlay, David, Jacoby, R, Johnson, T., Hughes, A., Barber, R., Howard, Robert, Jessica Adams (2640001), Jones, Roy W., O'Brien, J. T., R. McShane (7608791), Howard, R, Holmes, Clive, Katona, C, Lindesay, J, I. McKeith (7608788), Ritchie, C, Adams, J., A. Macharouthu (7608794), T. Johnson (7602368), Johnson, Tony, McKeith, I. G., A. Hughes (7190519), Jones, Rob, Caroline Onions (16155023), Katona, C. L. E., R. Hills (7635896), John O'Brien (377563), Hills, Robert, Hughes, A, Lindesay, James, Hills, R, Rob Jones (3023226), Tony Johnson (1947625), Onions, Caroline, Griffin, Mary, C. Ritchie (7608806), Onions, C, Richard Brown (130157), Katona, Cornelius, Baldwin, Ashley, Sheehan, B, Adams, J, Burns, Alistair, Burns, Alistair S., Griffin, M., R. Jones (3979994), Ballard, Clive, C. Onions (7608764), Alistair Burns (3580904), Findlay, D, O'Brien, J, Bentham, P, R. Gray (7608782), Ajay Macharouthu (6553472)   +147 more
core   +1 more source

Application of an electrometric method for measurement of in vitroinhibition of blood cholinesterases from sheep, goats and cattle by dichlorvos and carbaryl

Veterinární Medicína, 2006
A modified electrometric method was described in sheep, goats and cattle and used to demonstrate in vitro inhibition of plasma and erythrocyte cholinesterase activities by the organophosphate and carbamate insecticides dichlorvos and carbaryl ...
F.K. Mohammad, B.K. Al-Baggou', A.S. Alias, G.A.M. Faris   +3 more
doaj   +1 more source