Results 21 to 30 of about 53,217 (270)

Plant Terpenoids as the Promising Source of Cholinesterase Inhibitors for Anti-AD Therapy

Biology, 2022
Plant-derived terpenes are the prolific source of modern drugs such as taxol, chloroquine and artemisinin, which are widely used to treat cancer and malaria infections.
Shereen Lai Shi Min, Sook Yee Liew, Nelson Jeng Yeou Chear, Bey Hing Goh, Wen-Nee Tan, Kooi Yeong Khaw   +5 more
doaj   +1 more source

CHOLINESTERASE INHIBITORS: A LITERATURE REVIEW OF MEDICATION EFFICACY AND SAFETY FOR ALZHEIMER'S DISEASE [PDF]

, 2021
Background: With a steady increase of seniors in Canada’s overall population, geriatric-associated illnesses such as Alzheimer’s disease (AD) will continue to rise. AD is a progressive neurodegenerative disorder that causes plaque build-up in the brain
Wicklund, Ashley
core  

In Vitro Enzymatic and Kinetic Studies, and In Silico Drug-Receptor Interactions, and Drug-Like Profiling of the 5-Styrylbenzamide Derivatives as Potential Cholinesterase and β-Secretase Inhibitors with Antioxidant Properties

Antioxidants, 2021
The 5-(styryl)anthranilamides were transformed into the corresponding 5-styryl-2-(p-tolylsulfonamido)benzamide derivatives. These 5-styrylbenzamide derivatives were evaluated through enzymatic assays in vitro for their capability to inhibit ...
Malose J. Mphahlele, Emmanuel N. Agbo, Garland K. More, Samantha Gildenhuys   +3 more
doaj   +1 more source

Evaluation of Cholinesterase Activities During in Vivo Intoxication Using an Electrochemical Sensor Strip – Correlation With Intoxication Symptoms

Sensors, 2009
Cholinesterase activity in blood of laboratory rats was monitored. Rats were intoxicated with paraoxon at dosis of 0 – 65 – 125 – 170 – 250 – 500 nmol. The 250 nmol dose was found to be the LD50.
Jana Zdarova-Karasova, Martina Hrabinova, Kamil Kuca, Ladislav Novotný, Jan Misík, Miroslav Pohanka   +5 more
doaj   +1 more source

Evaluation of Toxic Effects Induced by Sub-Acute Exposure to Low Doses of α-Cypermethrin in Adult Male Rats

Toxics, 2022
To contribute new information to the pyrethroid pesticide α-cypermethrin toxicity profile, we evaluated its effects after oral administration to Wistar rats at daily doses of 2.186, 0.015, 0.157, and 0.786 mg/kg bw for 28 days. Evaluations were performed
Vilena Kašuba, Blanka Tariba Lovaković, Ana Lucić Vrdoljak, Anja Katić, Nevenka Kopjar, Vedran Micek, Mirta Milić, Alica Pizent, Davor Želježić, Suzana Žunec   +9 more
doaj   +1 more source

Assessment of serum level cholinesterase as a biomarker of liver cirrhosis in Egyptian cirrhotic patients

Gastroenterology Insights, 2017
Serum cholinesterase levels are closely correlated with the severity of liver disease. The aim of the paper was to assess the value of serum cholinesterase in evaluating liver reserve function in cirrhotic patients.
Mona A. Amin, Marwa E. El-Shahat, Nouman El-Garem, Ahmed Soliman, Eman Obaia   +4 more
doaj   +1 more source

DOMINO-AD protocol : donepezil and memantine in moderate to severe Alzheimer's disease – a multicentre RCT [PDF]

, 2009
Background: Alzheimer's disease (AD) is the commonest cause of dementia. Cholinesterase inhibitors, such as donepezil, are the drug class with the best evidence of efficacy, licensed for mild to moderate AD, while the glutamate antagonist memantine has
Ashley Baldwin, Ajay Macharouthu, Juszczak, E, R. Brown (3682735), Raftery, James, Jones Rob, Gray, R, Ballard, C, Burns, Alistair; id_orcid, Adams, Jessica, Knapp, M, Raftery James, J. Adams (7579901), Knapp, Martin, Griffin Mary, Ian McKeith, Baldwin, A, P. Passmore (7608800), Dening, Tom, Griffin, M, S. Banerjee (1503751), B. Sheehan (7608761), Jones Roy, Jones, Roy, T. Dening (7608776), Sube Banerjee, Sheehan, Bart, McShane, R, Patrick Phillips, Bentham, Peter, Findlay David, O'Brien, John, Alistair Burns, Barber, Bob, McShane, Rupert, Brown, R, Ritchie Craig, Dening, T, Hughes, Alan, J. Raftery (7608803), O'Brien John, Richard Brown, Holmes, C, Jessica Adams, Jacoby, Robin, Phillips, Patrick, McShane Rupert, Dening Tom, Clive Holmes, D. Findlay (7608779), Ballard Clive, Bart Sheehan, Rob Jones, Raftery, J, Brown, R. G., McKeith, I, Ritchie, C. W., A. Baldwin (7608767), Ritchie, Craig, P. Phillips (5239541), DOMINO-AD team, Banerjee, S, Ed Juszczak, P. Bentham (7589273), Juszczak, Ed, James. Lindesay (7608785), Robin Jacoby, Alan Hughes, Bob Barber, Richard Gray, Barber, B, Tony Johnson, Knapp Martin, Baldwin Ashley, Clive Ballard, Peter Bentham, Brown, Richard, McKeith, Ian, Brown, Richard; id_orcid, Juszczak Ed, Phillips Patrick, James Raftery, E. Juszczak (7589267), Burns, A, Howard Rob, Banerjee, Sube, Macharouthu, Ajay, Passmore, P, Brown Richard, Jones, R, Hughes Alan, Gray, Richard, Phillips, P, R. Jacoby (7589288), J. O'Brien (7608797), Phillips, P., Macharouthu Ajay, A. Burns (842688), R. Howard (1274091), Juszczak, Edmund, C. Holmes (7589285), Howard, Rob, M. Griffin (3933326), Macharouthu, A, M. Knapp (2534038), Jones, R. G., C. Ballard (7608770), Passmore, Peter, Johnson, T, Rob Howard, Holmes Clive, Sheehan Bart, Findlay, David, Rupert McShane, Jacoby, R, James Lindesay, Johnson, T., Hughes, A., Craig Ritchie, Howard, Robert, Jones, Roy W., O'Brien, J. T., David Findlay, R. McShane (7608791), Howard, R, Tom Dening, Onions Caroline, Holmes, Clive, McKeith Ian, Lindesay, J, Johnson Tony, Gray Richard, Barber Bob, I. McKeith (7608788), Ritchie, C, Burns Alistair, Adams, J., T. Johnson (7602368), A. Macharouthu (7608794), Johnson, Tony, Lindesay James, McKeith, I. G., A. Hughes (7190519), Jones, Rob, Banerjee Sube, Bentham Peter, Hughes, A, Lindesay, James, Raftery, J. P., Adams Jessica, Mary Griffin, Onions, Caroline, Griffin, Mary, C. Ritchie (7608806), Onions, C, Peter Passmore, John O'Brien, Baldwin, Ashley, Sheehan, B, Adams, J, Burns, Alistair, Jacoby Robin, Burns, Alistair S., Griffin, M., Passmore Peter, Roy Jones, R. Jones (3979994), Ballard, Clive, C. Onions (7608764), Bentham, P, Findlay, D, O'Brien, J, B. Barber (7608773), R. Gray (7608782), Martin Knapp, Caroline Onions   +175 more
core   +3 more sources

Sulfonamide-Based 2-Amino-1,3,4-Oxadiazole Derivatives as Dual Cholinesterase and Carbonic Anhydrase Inhibitors: Design, Synthesis, Kinetic Characterization, Molecular Modeling, and ADMET Evaluation. [PDF]

Drug Dev Res
ABSTRACT In this study, 12 novel sulfonamide derivatives incorporating 2‐amino‐1,3,4‐oxadiazole and 1,3‐benzazol‐2(3H)‐one scaffolds were synthesized and structurally characterized using 1H NMR, 13C NMR, and LC–MS analyses. Their inhibitory activities were evaluated against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), carbonic anhydrase I
Arslan Karahan G, Gökçe B, Muhammed MT, Ayan EK, Özçelik AB.   +4 more
europepmc   +2 more sources

Evaluation of acetylcholine esterase activity in the blood of workers exposed [PDF]

Kirkuk Journal of Science, 2013
Introduction:Organophosphate and carbamate insecticides pose major environmental pollution problems and health hazards to people and animals. These insecticides inhibit cholinesterase (ChE) activity in the nervous tissues and neuromuscular junctions.
Aydin S. Ahmed
doaj   +1 more source

Correlations between the value of serum cholinesterase and Child-Pugh and Meld-Na scores in cirrhotic patients [PDF]

Romanian Journal of Infectious Diseases, 2022
To determine the degree of the liver failure in cirrhotic patients we use serum liver function tests In contrast with tests, serum cholinesterase values are low in liver failure. Purpose of the study is to establish if serum cholinesterase corelates with
George Stancu, Bogdan Sorohan, George Gherlan, Letitia Toma, Laura Elena Iliescu   +4 more
doaj   +1 more source