Results 51 to 60 of about 49,840 (263)

Nuclear Alpha‐Synuclein: Mechanisms and Implications for Synucleinopathies

Movement Disorders, EarlyView.
Abstract Alpha‐synuclein (aSyn), historically studied for its synaptic functions and central role in Lewy body pathology, is emerging as a protein with significant nuclear activities relevant to Parkinson's disease (PD) and related synucleinopathies. Recent advances reveal that aSyn dynamically localizes to neuronal nuclei in both health and disease ...
Tiago Fleming Outeiro, David J. Koss
wiley   +1 more source

Serum β2-MG, sCHE, and PSGL-1 Expression in Patients with Esophageal Cancer and Their Association with Postoperative Lung Infection After Mediastinoscopy

Zhongliu Fangzhi Yanjiu
ObjectiveTo investigate serum β2-MG, sCHE, and PSGL-1 expression in patients with esophageal cancer and their relationship to lung infection after mediastinoscopy.
Yu FENG, Rulin QIAN, Dong CUI, Chaoying CHANG, Maolin CHEN   +4 more
doaj   +1 more source

Rapid Structural Analysis of Natural Products Using MicroED

Small, EarlyView.
The cryoEM method, MicroED used for rapid analysis and structure determination of natural products that remained unattainable by other structural biology methods ABSTRACT Structural analysis of natural products remains challenging due to their inherent complexity and limited availability.
Jieye Lin, Orel Paz, Johan Unge, Tamir Gonen   +3 more
wiley   +1 more source

The genome and stage‐specific transcriptomes of the carrot weevil, Listronotus oregonensis, reveal adaptive mechanisms for host specialisation and symbiotic interactions

Insect Molecular Biology, EarlyView.
Comprehensive genome and stage‐specific transcriptomes reveal 14,637 genes in Listronotus oregonensis, advancing genetic insights into a key agricultural pest. Compared with related species, L. oregonensis exhibits reduced chemoreceptor gene families but expanded detoxification gene clusters, reflecting its narrow host range and adaptability.
Dave T. Ste‐Croix, Annie‐Ève Gagnon, Benjamin Mimee   +2 more
wiley   +1 more source

Beneficiary Effect of Zinc Supplementation in Tuberculosis as Reflected by Serum Level of Diagnostic Biomolecules [PDF]

Indian Journal of Medical Biochemistry
Aim and objective: This author had indoctrinated a higher Mycobacterium tuberculosis (Mtb) origin serum superoxide dismutase (SOD), detectable Mtb origin serum glutamine synthetase (GS) and inhibited host origin serum cholinesterase (ChE) as diagnostics ...
Dipak Kumar Chattopadhyay
doaj   +1 more source

Frailty and Health Outcomes in People 65 Years or Older Living With Dementia: A Systematic Review of the Literature

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Introduction Although frailty is considered a potentially modifiable risk factor for dementia, its influence on health outcomes in individuals with established dementia remains unclear. This study aims to systematize the current evidence to understand the impact of frailty on the development of adverse outcomes in older adults with dementia ...
Miguel German Borda, Luis Carlos Venegas‐Sanabria, Marco Canevelli, Francesco Landi, Salomón Páez‐García, Kevin O'Hara‐Veintimilla, Lindsay Wallace, Kenneth Rockwood, Tommy Cederholm, Gustavo Duque, Mario Ulises Pérez‐Zepeda, Dag Aarsland   +11 more
wiley   +1 more source

Predictors of a Gabapentinoid–Loop‐Diuretic Prescribing Cascade in U.S. Nursing Home Residents

Journal of the American Geriatrics Society, EarlyView.
Among 23,544 older adult long‐stay nursing home residents who initiated a gabapentinoid in the nursing home (2016–2022), 4.2% experienced a loop diuretic prescribing cascade within 90 days. Predictors of the prescribing cascade included older age, higher medication burden (≥ 15 medications), current receipt of non‐loop diuretics, and titration of ...
Kaleen N. Hayes, Emmanuelle Belanger, Arman Oganisian, Richa Joshi, Xiao (Joyce) Wang, Lexie R. Grove, Kelsey L. Corcoran, Andrew R. Zullo   +7 more
wiley   +1 more source

A Retrospective Chart Review of the Prevalence, Characteristics, and Discharge Destinations of Patients Hospitalized as “Social Admissions”

Journal of the American Geriatrics Society, EarlyView.
Overview of study.
Jasmine Mah, Lucy Eum, Lindsey Puddicombe, Christie Stilwell, Karen Nicholls, Hamish Frayne, Clara Long, Kristin Ko, Victoria Howatt, Margaret Man‐Ger Sun, Lynnea Lobert, Gali Latariya, Katalin Koller, Susan Freter, Maia von Maltzahn, Kenneth Rockwood, Samuel D. Searle, Melissa K. Andrew   +17 more
wiley   +1 more source

Sensorimotor Impairment and Incident Dementia in the US Medicare Beneficiaries

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Sensorimotor impairments, including sensory (vision and hearing) and motor (standing balance, gait, chair stands, grip strength) deficits, are prevalent in older adults and are associated with an increased risk of dementia. Understanding the individual and combined effects of these impairments on dementia risk may enhance early ...
Anis Davoudi, Ryan J. Dougherty, Amal A. Wanigatunga, Yuri Agrawal, Nicholas S. Reed, Joshua R. Ehrlich, Alden L. Gross, Jennifer A. Schrack   +7 more
wiley   +1 more source

Association of Palliative Care Initiation With Acute Healthcare Utilization Among Community‐Dwelling Adults Living With Dementia

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Objectives To measure the association between initiating palliative care using the combined criteria of short survival expectations and increased care needs with acute healthcare utilization among community‐dwelling people living with dementia. Design A population‐level propensity‐based overlap‐weighted cohort study.
Kieran L. Quinn, Thérèse A. Stukel, Michael Pugliese, Allan S. Detsky, George Heckman, Mariam Toluwalashe Omilabu, Nathan M. Stall, Desiree Vaz, Colleen Webber, Peter Tanuseputro, Sarina Isenberg   +10 more
wiley   +1 more source