Results 71 to 80 of about 131,500 (355)

A Heparin‐Functionalized Scaffold with HB‐EGF Immobilization for Tissue Engineering

Advanced Healthcare Materials, EarlyView.
In this study, a heparin‐functionalized scaffold is designed for bio‐mimicking growth factors reservoir function of extracellular matrix. Due to the presence of heparin‐binding domain, heparin‐binding epidermal growth factor‐like growth factor (HB‐EGF) is effectively and spatially captured by heparin‐functionalized scaffold.
Bowu Peng, Huajian Chen, Chengyu Lu, Tianjiao Zeng, Man Wang, Toru Yoshitomi, Naoki Kawazoe, Yingnan Yang, Guoping Chen   +8 more
wiley   +1 more source

Platelet Rich Plasma Combined with Collagen Matrix Promotes Chondrocyte Regeneration in Arthritis and the Effect of Nanoparticles on Oxygen Free Radicals [PDF]

, 2022
Qiumin Li, J Dequeker, L Mokassa, J Aerssens, S Boonen, T Oegema, R Carpenter, F Hofmeister, R Thompson, Y Cheng, C Macera, D Davis, B Ainsworth, S Blair, G Zhen, C Wen, X Jia, Y Li, J Crane, S Mears, E Blaney Davidson, D Van, M Weinberger, W Tierney, P Booher, S Hiner, Baselga Garc A-Escudero, Miguel Jaime, Trillos Hernndez, Pedro, A Shervin, E Livne, Andr Snchez, P Sheridan, L Kupp, A Pradeep, S Pai, G Garg, P Devi, S Shetty, M Takikawa, S Nakamura, S Nakamura, M Ishirara, T Kiyosawa, L Chamberlain, I Yannas, H Hsu, G Strichartz, M Spector, P Van Wachem, M Van Luyn, D Ponte, S Miranda, M Costa, Natlia Rebouas, T Mrcia, Ramos, N Alencar, G Hoareau, K Jandrey, J Burges, D Bremer, F Tablin   +63 more
openalex   +1 more source

Platelet Lysate–Enriched Human Induced Pluripotent Stem Cell–Derived Chondrocyte Sheets for Bone Defect Repair via Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human iPSC‐derived hypertrophic chondrocyte sheet promotes bone regeneration. Abstract Bone defects are a major clinical challenge, primarily owing to the limited self‐healing capacity of bones and the high risk of complications associated with conventional treatment strategies.
Yiwei Chen, Jiali Lin, Jiapeng Li, Yiwei Hu, Jiansen Su, Yu Miao, Lanlan Wang, Qian Tang, Changqing Zhang, Junhui Yin   +9 more
wiley   +1 more source

Mesenchymal Stem Cell‐Derived Apoptotic Micro‐Vesicles Repaired Sciatic Nerve Defect by Regulating Early Inflammatory Microenvironment and Promoting Angiogenesis

Advanced Healthcare Materials, EarlyView.
HUCMSC‐Apo‐mvs enhance peripheral nerve repair by modulating the inflammatory microenvironment (IME), primarily through coordinated actions on three functional cells. They recruit macrophages and promote their polarization from pro‐inflammatory M1 to anti‐inflammatory M2 phenotypes, increasing secretion of IL‐10 and VEGF.
Haolin Liu, Yiben Ouyang, Bo Wang, Xiaochun Zhang, Yanjun Guan, Ruichao He, Yuhui Cui, Junli Wang, Qianru Yao, Yixiao Tan, Xiwei Peng, Xing Xiong, Sice Wang, Dongdong Li, Haofeng Cheng, Tianqi Su, Xiaoyang Fu, Jinjuan Zhao, Mingqian Yu, Yi Wang, Jiang Peng, Yu Wang   +21 more
wiley   +1 more source

Low-intensity pulsed ultrasound inhibits chondrocyte senescence by inhibiting PI3K/AKT/mTOR signaling

Brazilian Journal of Medical and Biological Research
Cellular senescence is an important cause of age-related degenerative diseases, including osteoarthritis (OA). Chondrocyte senescence is crucial in OA onset and progression.
Wang Han, Mengtong Guan, Bo Liao, Xiaoyu Han, Kaiting Li, Qing Chen, Xiya Guo, Yajuan Niu, Ying Zhu, Dingqun Bai   +9 more
doaj   +1 more source

Kidney Organoids in Drug Development: Integrating Technological Advances and Standardization for Effective Implementation

Advanced Healthcare Materials, EarlyView.
This review examines how emerging enabling technologies enhance the physiological relevance, scalability, and reproducibility of kidney organoids, while advanced analytical approaches support model validation and deepen mechanistic insight into nephrotoxicity.
Helen Kearney, Silvia M. Mihăilă, Lorenzo Moroni, Carlos Mota   +3 more
wiley   +1 more source

MicroRNA-34a affects chondrocyte apoptosis and proliferation by targeting the SIRT1/p53 signaling pathway during the pathogenesis of osteoarthritis

International Journal of Molecular Medicine, 2016
Osteoarthritis (OA) is the most prevalent degenerative joint disease with multifactorial etiology caused by risk factors such as ageing, obesity and trauma.
Shiju Yan, Meng Wang, Jian Zhao, Hongtao Zhang, Chengpei Zhou, Lei Jin, Yinglong Zhang, X. Qiu, Baoan Ma, Qing-yu Fan   +9 more
semanticscholar   +1 more source

A Synovium‐on‐Chip Platform to Study Multicellular Interactions in Arthritis

Advanced Healthcare Materials, EarlyView.
The Synovium‐on‐Chip comprises a thin microporous PDMS membrane to support co‐culture of fibroblast‐like synoviocytes (FLS), THP‐1‐derived macrophages, and endothelial cells, enabling real‐time analysis of synovial‐vascular interactions. FLS migration through the pores drives endothelial remodeling, while TNF‐α stimulation induces robust inflammatory ...
Laurens R. Spoelstra, Fleur R. Semmekrot, Nuno Araújo‐Gomes, Daniël Wijnperle, Monique M. A. Helsen, Martijn H.J. Van Den Bosch, Loes. I. Segerink, Séverine Le Gac, Marcel Karperien   +8 more
wiley   +1 more source

The Signaling Pathways Involved in Chondrocyte Differentiation and Hypertrophic Differentiation

Stem Cells International, 2016
Chondrocytes communicate with each other mainly via diffusible signals rather than direct cell-to-cell contact. The chondrogenic differentiation of mesenchymal stem cells (MSCs) is well regulated by the interactions of varieties of growth factors ...
Jianmei Li, S. Dong
semanticscholar   +1 more source

BNIP3 decreases the LPS-induced inflammation and apoptosis of chondrocytes by promoting the development of autophagy [PDF]

, 2020
Zetao Ma, Deli Wang, Jian Weng, Sheng Zhang, Yuanshi Zhang   +4 more
openalex   +1 more source