Results 71 to 80 of about 129,913 (308)

Biomarkers of Chondrocyte Apoptosis and Autophagy in Osteoarthritis

International Journal of Molecular Sciences, 2015
Cell death with morphological and molecular features of apoptosis has been detected in osteoarthritic (OA) cartilage, which suggests a key role for chondrocyte death/survival in the pathogenesis of OA.
G. Musumeci, P. Castrogiovanni, F. Trovato, A. Weinberg, M. K. Al-Wasiyah, M. Alqahtani, A. Mobasheri   +6 more
semanticscholar   +1 more source

Microphysiological Systems for Comorbidity Studies: Chronic Kidney Disease and Osteoarthritis

Advanced Healthcare Materials, EarlyView.
This review highlights the potential of organ‐on‐a‐chip systems for studying comorbidities, using chronic kidney disease (CKD) and osteoarthritis (OA) as examples. It summarizes recent advances in kidney‐on‐a‐chip and joint‐on‐a‐chip models and discusses their current and potential application in investigating CKD, OA, and CKD‐OA comorbidity, aiming to
Mingying Han, Weiping Lin, Yuanxiong Cao, Patricia Murray, Bettina Wilm, Stephen J McWilliam, Jude Curran, Ruoxiao Xie   +7 more
wiley   +1 more source

Low-intensity pulsed ultrasound inhibits chondrocyte senescence by inhibiting PI3K/AKT/mTOR signaling

Brazilian Journal of Medical and Biological Research
Cellular senescence is an important cause of age-related degenerative diseases, including osteoarthritis (OA). Chondrocyte senescence is crucial in OA onset and progression.
Wang Han, Mengtong Guan, Bo Liao, Xiaoyu Han, Kaiting Li, Qing Chen, Xiya Guo, Yajuan Niu, Ying Zhu, Dingqun Bai   +9 more
doaj   +1 more source

Irisin Mitigates Oxidative Stress, Chondrocyte Dysfunction and Osteoarthritis Development through Regulating Mitochondrial Integrity and Autophagy

Antioxidants, 2020
Compromised autophagy and mitochondrial dysfunction downregulate chondrocytic activity, accelerating the development of osteoarthritis (OA). Irisin, a cleaved form of fibronectin type III domain containing 5 (FNDC5), regulates bone turnover and muscle ...
Feng-Sheng Wang, Chung-Wen Kuo, Jih-Yang Ko, Yu-Shan Chen, Shao-Yu Wang, Huei-Jing Ke, Pei-Chen Kuo, Chin-Huei Lee, Jian-Ching Wu, Wen-Bin Lu, Ming-Hong Tai, Holger Jahr, Wei-Shiung Lian   +12 more
doaj   +1 more source

Conditioned Media from Mechanically Stimulated Macrophages Upregulate Osteogenic Genes in Human Mesenchymal Stromal Cells

Advanced Healthcare Materials, EarlyView.
Bone fracture healing is a complex, timely orchestrated scenario involving multiple cell types and a plethora of cytokines and regulatory factors. To gain further insight, an in vitro model to a) study macrophage polarization under mechanical load in a fibrin hydrogel and b) subsequently assess the effect of conditioned media derived from macrophages ...
Anne Géraldine Guex, Ursula Menzel, Yann Ladner, Angela R. Armiento, Martin J. Stoddart   +4 more
wiley   +1 more source

Influence of heat stress on sirt1 transfected chondrocytes [PDF]

, 2021
Kenta Kaihara, Hiroyuki Inoue, Shinichi Nakagawa, Yuji Arai, Yutaka Fujii, Y. Kamada, Osam Mazda, Kenji Takahashi   +7 more
openalex   +1 more source

Cell Calcification Models and Their Implications for Medicine and Biomaterial Research

Advanced Healthcare Materials, EarlyView.
Calcification, is the process by which the tissues containing minerals are formed, occurring during normal physiological processes, or in pathological conditions. Here, it is aimed to give a comprehensive overview of the range of cell models available, and the approaches taken by these models, highlighting when and how methodological divergences arise,
Luke Hunter, Caterina Vanelli Coralli, Robert Dzhanaev, Aaron Morgan, Willi Jahnen‐Dechent, Sergio Bertazzo   +5 more
wiley   +1 more source

A single-cell 3D dynamic volume control system for chondrocytes

BioTechniques
In articular cartilage, zone-specific cellular morphology is a typical characteristic of cartilage tissue, which is related with chondrocyte function, inflammation and osteoarthritis (OA).
Qiang Zhang, Yiyao Wang, Yanjun Zhang, Xiaochun Wei, Weiyi Chen, Quanyou Zhang   +5 more
doaj   +1 more source

Single-cell RNA seq analysis identifies the biomarkers and differentiation of chondrocyte in human osteoarthritis [PDF]

, 2020
Xiaolu Zhang, Nianlai Huang, Rongfu Huang, Liangming Wang, Qingfeng Ke, Liquan Cai, Shiqiang Wu   +6 more
openalex   +1 more source

mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation

Nature Communications, 2016
Precise coordination of cell growth, proliferation and differentiation is essential for the development of multicellular organisms. Here, we report that although the mechanistic target of rapamycin complex 1 (mTORC1) activity is required for chondrocyte ...
B. Yan, Zhongmin Zhang, Dadi Jin, Chen-Ge Cai, Chunhong Jia, Wen Liu, Ting Wang, Sheng-fa Li, Haiyan Zhang, Bin Huang, Pinglin Lai, Hua Wang, Anling Liu, C. Zeng, D. Cai, Yu Jiang, X. Bai   +16 more
semanticscholar   +1 more source