Results 71 to 80 of about 64,494 (318)

Unveiling the potential of MSC extracellular vesicles: MiR-122-5p enhancing chondrocyte regeneration in osteoarthritis via autophagy mechanism

Stem Cell Research & Therapy
Background Osteoarthritis (OA) is one of the most prevalent degenerative joint diseases, while the mechanism by which extracellular vesicles (EVs) promote chondrocyte regeneration remains unclear. The study assessed the effect of hypoxic mesenchymal stem
Haifeng Zhang, Yanmeng Yang, Yingnan Wu, Vinitha Denslin, Yi Wei Justin Koh, Ling Liu, Wenhai Zhuo, Wing Moon Raymond Lam, Yinxian Yu, James Hoi Po Hui, Zheng Yang   +10 more
doaj   +1 more source

Effects of mechanical stress on chondrocyte phenotype and chondrocyte extracellular matrix expression [PDF]

Scientific Reports, 2016
AbstractMechanical factors play a key role in regulating the development of cartilage degradation in osteoarthritis. This study aimed to identify the influence of mechanical stress in cartilage and chondrocytes. To explore the effects of mechanical stress on cartilage morphology, we observed cartilages in different regions by histological and ...
Xiaoning Duan, Qiang Liu, Yingfang Ao, Xin Zhang, Fengyuan Zhao, Xiaoqing Hu, Peng Yang   +6 more
openaire   +3 more sources

Engineering Anisotropic Mechanical Properties in Large‐Scale Fabricated Cartilage Constructs Using Microfiber Reinforcement

Advanced Healthcare Materials, EarlyView.
This study presents the development of large‐scale (15 cm2) cartilage constructs with anisotropic mechanical properties using melt electrowritten (MEW) microfiber reinforced cell‐laden gelatin methacryloyl (gelMA). These constructs mimic the mechanical behavior of native cartilage, providing a suitable environment for Articular Cartilage ...
Lennard Spauwen, Alba Pueyo Moliner, Patrick van Veenendaal, Roel Custers, Jos Malda, Mylène de Ruijter   +5 more
wiley   +1 more source

Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis [PDF]

Osteoarthritis (OA), a chronic disease characterized by articular cartilage degeneration, is a leading cause of disability and pain worldwide. In OA, chondrocytes in cartilage undergo phenotypic changes and senescence, restricting cartilage regeneration and favouring disease progression.
arxiv   +1 more source

Modeling the Effect of Blunt Impact on Mitochondrial Dysfunction in Cartilage [PDF]

, 2016
Mounting evidence for the role of oxidative stress in the degeneration of articular cartilage after an injurious impact requires our modeling & simulation efforts to temporarily shift from just describing the effect of mechanical stress and inflammation on osteoarthritis (OA).
arxiv   +1 more source

Low-intensity pulsed ultrasound inhibits chondrocyte senescence by inhibiting PI3K/AKT/mTOR signaling

Brazilian Journal of Medical and Biological Research
Cellular senescence is an important cause of age-related degenerative diseases, including osteoarthritis (OA). Chondrocyte senescence is crucial in OA onset and progression.
Wang Han, Mengtong Guan, Bo Liao, Xiaoyu Han, Kaiting Li, Qing Chen, Xiya Guo, Yajuan Niu, Ying Zhu, Dingqun Bai   +9 more
doaj   +1 more source

Potassium channels in articular chondrocytes [PDF]

Channels, 2012
Chondrocytes are the resident cells of cartilage, which synthesize and maintain the extracellular matrix. The range of known potassium channels expressed by these unique cells is continually increasing. Since chondrocytes are non-excitable, and do not need to be repolarized following action potentials, the function of potassium channels in these cells ...
Mobasheri, A, Lewis, R, Ferreira-Mendes, A, Rufino, A, Dart, C, Barrett-Jolley, R   +5 more
openaire   +4 more sources

Immunosuppressive Cytokine‐Tethered Hydrogel for Treating Rheumatoid Arthritis

Advanced Healthcare Materials, EarlyView.
An injectable hydrogel is developed by chemically tethering IL‐4, an immunosuppressive cytokine, to a hyaluronic acid‐based backbone. The hydrogel reduces joint friction and exerts immunomodulatory effects. In a rheumatoid arthritis (RA) mouse model, it reduced inflammation, preserved cartilage, and promoted anti‐inflammatory immune responses.
Woojin Back, Moonkyoung Jeong, Huyen‐Thao Le, Ji‐Ho Park   +3 more
wiley   +1 more source

Adipochondrocytes in rabbit auricular cartilage [PDF]

arXiv, 2018
Chondrocytes are described as one cell population in different cartilage types. The auricular cartilage in mouse and rat contains unique chondrocytes similar in morphology to white adipocytes and known as lipochondrocytes. Lipochondrocytes were not mentioned in other species. The current study aimed to explore the existence of this cell type in rabbits.
arxiv  

From Mechanoelectric Conversion to Tissue Regeneration: Translational Progress in Piezoelectric Materials

Advanced Materials, EarlyView.
This review highlights recent progress in piezoelectric materials for regenerative medicine, emphasizing their ability to convert mechanical stimuli into bioelectric signals that promote tissue repair. Key discussions cover the intrinsic piezoelectric properties of biological tissues, co‐stimulation cellular mechanisms for tissue regeneration, and ...
Xinyu Wang, Sílvio Terra Stefanello, Victor Shahin, Yun Qian   +3 more
wiley   +1 more source