Molecular Mechanisms of Chondrocyte Proliferation and Differentiation [PDF]
Frontiers in Cell and Developmental Biology, 2021 Cartilage is a kind of connective tissue that buffers pressure and is essential to protect joint movement. It is difficult to self-recover once cartilage is damaged due to the lack of blood vessels, lymph, and nerve tissues. Repair of cartilage injury is
Hui Chen +15 more
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miR‐373 regulates inflammatory cytokine‐mediated chondrocyte proliferation in osteoarthritis by targeting the P2X7 receptor [PDF]
FEBS Open Bio, 2018 Inflammatory cytokines commonly initiate extreme changes in the synovium and cartilage microenvironment of osteoarthritis (OA) patients, which subsequently cause cellular dysfunction, especially in chondrocytes. It has been reported that induction of the
Wei Zhang +4 more
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Chondrocyte Spheroids Laden in GelMA/HAMA Hybrid Hydrogel for Tissue-Engineered Cartilage with Enhanced Proliferation, Better Phenotype Maintenance, and Natural Morphological Structure [PDF]
Gels, 2021 Three-dimensional cell-laden tissue engineering has become an extensive research direction. This study aimed to evaluate whether chondrocyte spheroids (chondro-spheroids) prepared using the hanging-drop method could develop better cell proliferation and ...
Guanhuier Wang +5 more
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Atoh8 acts as a regulator of chondrocyte proliferation and differentiation in endochondral bones. [PDF]
PLoS ONE, 2019 Atonal homolog 8 (Atoh8) is a transcription factor of the basic helix-loop-helix (bHLH) protein family, which is expressed in the cartilaginous elements of endochondral bones. To analyze its function during chondrogenesis we deleted Atoh8 in mice using a
Nadine Schroeder +4 more
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SFMBT2 positively regulates SOX9 and chondrocyte proliferation
International Journal of Molecular Medicine, 2018 SRY‑box 9 (SOX9) is the master regulator of the chondrocyte phenotype, which is essential for differentiating chondrogenic mesenchymal condensations into chondrocytes, and is involved in regulating every stage of chondrocyte differentiation.
Saddam Hussain +13 more
semanticscholar +6 more sources
De novo serine synthesis regulates chondrocyte proliferation during bone development and repair. [PDF]
Bone Res, 2022 The majority of the mammalian skeleton is formed through endochondral ossification starting from a cartilaginous template. Cartilage cells, or chondrocytes, survive, proliferate and synthesize extracellular matrix in an avascular environment, but the ...
Stegen S +5 more
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USP7 Attenuates Endoplasmic Reticulum Stress and NF-κB Signaling to Modulate Chondrocyte Proliferation, Apoptosis, and Inflammatory Response under Inflammation. [PDF]
Oxid Med Cell Longev, 2022 The purpose of this research was to observe the functions and mechanisms of ubiquitin‐specific peptidase 7 (USP7) on chondrocytes under tumor necrosis factor alpha‐ (TNF‐α‐) induced inflammation.
Dong X +6 more
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Mechanism of Abnormal Chondrocyte Proliferation Induced by Piezo1-siRNA Exposed to Mechanical Stretch. [PDF]
Biomed Res Int, 2020 Objective To investigate the effect of small interfering RNA targeting mechanosensitive ion channel protein Piezo1 (Piezo1-siRNA) on abnormal chondrocyte proliferation exposed to mechanical stretch.
Sun Y +6 more
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Antxr1, Which is a Target of Runx2, Regulates Chondrocyte Proliferation and Apoptosis. [PDF]
Int J Mol Sci, 2020 Antxr1/Tem8 is highly expressed in tumor endothelial cells and is a receptor for anthrax toxin. Mutation of Antxr1 causes GAPO syndrome, which is characterized by growth retardation, alopecia, pseudo-anodontia, and optic atrophy.
Jiang Q +9 more
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Low-Intensity Pulsed Ultrasound Alleviates Osteoarthritis Condition Through Focal Adhesion Kinase-Mediated Chondrocyte Proliferation and Differentiation. [PDF]
Cartilage, 2021 Objective Osteoarthritis (OA) is a prevalent chronic multifactorial degenerative disease characterized by joint tissue inflammation, osteophyte formation, subchondral bone sclerosis, and articular cartilage degradation.
Sang F, Xu J, Chen Z, Liu Q, Jiang W.
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