Molecular Mechanisms of Chondrocyte Proliferation and Differentiation [PDF]
Frontiers in Cell and Developmental Biology, 2021 Cartilage is a kind of connective tissue that buffers pressure and is essential to protect joint movement. It is difficult to self-recover once cartilage is damaged due to the lack of blood vessels, lymph, and nerve tissues. Repair of cartilage injury is
Hui Chen +15 more
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Atoh8 acts as a regulator of chondrocyte proliferation and differentiation in endochondral bones. [PDF]
PLoS ONE, 2019 Atonal homolog 8 (Atoh8) is a transcription factor of the basic helix-loop-helix (bHLH) protein family, which is expressed in the cartilaginous elements of endochondral bones. To analyze its function during chondrogenesis we deleted Atoh8 in mice using a
Nadine Schroeder +4 more
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P-15 promotes chondrocyte proliferation in osteoarthritis by regulating SFPQ to target the Akt-RUNX2 axis [PDF]
Journal of Orthopaedic Surgery and Research, 2023 Background The disruption of chondrocyte proliferation and differentiation is a critical event during the process of joint injury in osteoarthritis (OA).
Yuanli Li +3 more
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Low fluid shear stress promotes chondrocyte proliferation and extracellular matrix secretion by downregulating mir-143-3p and activating the ERK5/KLF4 signaling pathway [PDF]
Scientific ReportsLow fluid shear stress (FSS, ≤ 2 dyn/cm2) has been shown to exert protective effects on chondrocytes, but the underlying molecular mechanisms remain unclear. This study aimed to elucidate the mechanisms by which FSS promotes chondrocyte proliferation and
Jun Zhao, Yayi Xia, Jinwen He
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Fibroblast growth factor receptor 3 effects on proliferation and telomerase activity in sheep growth plate chondrocytes [PDF]
Journal of Animal Science and Biotechnology, 2012 Background Fibroblast growth factor receptor 3 (FGFR3) inhibits growth-plate chondrocyte proliferation and limits bone elongation. Gain-of-function FGFR3 mutations cause dwarfism, reduced telomerase activity and shorter telomeres in growth plate ...
Smith Logan B +2 more
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De novo serine synthesis regulates chondrocyte proliferation during bone development and repair [PDF]
Bone Research, 2022 The majority of the mammalian skeleton is formed through endochondral ossification starting from a cartilaginous template. Cartilage cells, or chondrocytes, survive, proliferate and synthesize extracellular matrix in an avascular environment, but the ...
Steve Stegen +5 more
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G-protein-coupled estrogen receptor-1 facilitates chondrocyte proliferation in pubertal epiphyseal growth plate via PTHrP/Ihh regulation [PDF]
Bone & Joint ResearchAims: Oestrogen drives long-bone development through various oestrogen receptors. G-protein-coupled oestrogen receptor-1 (GPER-1), a membrane oestrogen receptor, mediates longitudinal bone growth during early puberty; however, the underlying mechanisms ...
Ya-Shuan Chou +6 more
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miR‐373 regulates inflammatory cytokine‐mediated chondrocyte proliferation in osteoarthritis by targeting the P2X7 receptor [PDF]
FEBS Open Bio, 2018 Inflammatory cytokines commonly initiate extreme changes in the synovium and cartilage microenvironment of osteoarthritis (OA) patients, which subsequently cause cellular dysfunction, especially in chondrocytes. It has been reported that induction of the
Wei Zhang +4 more
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Frontiers in Bioengineering and Biotechnology, 2021 Purpose: Extracellular Vesicles (EVs) derived from hMSCs, have the potential to alleviate cartilage damage and inflammation. We aimed to explore the effects of EVs derived from lncRNA malat‐1-overexpressing human mesenchymal stem cells (hMSCs) on ...
Chongzhi Pan +22 more
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Molecular mechanisms of long bone growth and chondrocyte regulation: A narrative review [PDF]
Precision and Future Medicine, 2023 Long bone growth is a fundamental determinant of final height. Growth, metabolism, and differentiation of chondrocytes, which are the key cellular players in this process, are regulated by systemic hormones, local factors, and cellular signaling pathways.
Eungu Kang
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