Results 31 to 40 of about 1,182,907 (370)
Molecular mechanisms of long bone growth and chondrocyte regulation: A narrative review [PDF]
Precision and Future Medicine, 2023 Long bone growth is a fundamental determinant of final height. Growth, metabolism, and differentiation of chondrocytes, which are the key cellular players in this process, are regulated by systemic hormones, local factors, and cellular signaling pathways.
Eungu Kang
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Chondrocyte proliferation in a new culture system [PDF]
Cell Proliferation, 2009 AbstractObjective: This study has aimed to study different culture systems that might stimulate an increase in cell proliferation of normal and osteoarthritis chondrocytes from articular cartilage in rat model.Material and Methods: Three culture systems using chondrocytes embedded in alginate beads were tested: chondrocytes cultured in Dulbecco's ...
M A, Gomez-Camarillo +4 more
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Integrin‐linked kinase regulates chondrocyte shape and proliferation [PDF]
EMBO reports, 2003 The interaction of chondrocytes with the extracellular‐matrix environment is mediated mainly by integrins. Ligated integrins are recruited to focal adhesions (FAs) together with scaffolding proteins and kinases, such as integrin‐linked kinase (Ilk). Ilk binds the cytoplasmic domain of β1‐, β2‐ and β3‐integrins and recruits adaptors and kinases, and is ...
Grashoff, C. +4 more
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Arthritis Research & Therapy, 2023 Background Osteoarthritis (OA) is a degenerative disease related to cholesterol metabolism disorders. However, current therapies for OA are insufficient and no convincing disease-modifying OA drugs exist. Therefore, we aimed to elucidate the mechanism by
WeiBing Wang +9 more
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Journal of Orthopaedic Surgery and Research, 2021 Background Osteoarthritis (OA) is a joint disease characterized via destruction of cartilage. Chondrocyte damage is associated with cartilage destruction during OA.
Jipeng Lu, Zhongxiong Wu, Ying Xiong
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Adipose-Derived Stem Cells Cocultured with Chondrocytes Promote the Proliferation of Chondrocytes [PDF]
Stem Cells International, 2017 Articular cartilage injury and defect caused by trauma and chronic osteoarthritis vascularity are very common, while the repair of injured cartilage remains a great challenge due to its limited healing capacity. Stem cell-based tissue engineering provides a promising treatment option for injured articular cartilage because of the cells potential for ...
Jie Shi +6 more
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Journal of Biochemistry (Tokyo), 2020 The dysregulation of circular RNAs (circRNAs) has been identified in various human diseases. Here, we probed into the potential mechanism of circRNA_0092516 in osteoarthritis (OA).
Zhihui Huang +4 more
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Journal of Orthopaedic Surgery and Research, 2022 Background This study aimed to analyze the in vitro effect of micro-strain stress on the proliferation and functional marker expression in chondrocytes isolated from human osteoarthritis cartilage samples.
Bin Zhao +3 more
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Dicer-dependent pathways regulate chondrocyte proliferation and differentiation [PDF]
Proceedings of the National Academy of Sciences, 2008 Small noncoding RNAs, microRNAs (miRNAs), bind to messenger RNAs through base pairing to suppress gene expression. Despite accumulating evidence that miRNAs play critical roles in various biological processes across diverse organisms, their roles in mammalian skeletal development have not been demonstrated. Here, we show that Dicer,
Kobayashi, Tatsuya +7 more
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Journal of Nanobiotechnology, 2021 Background Extracellular vesicles (EVs) secreted by mesenchymal stem cells (MSCs) may play a vital role in a variety of biological processes, including cartilage regeneration.
Shenglong Li +4 more
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