Cell Reports, 2016 Hippo signaling controls organ size and tissue regeneration in many organs, but its roles in chondrocyte differentiation and bone repair remain elusive. Here, we demonstrate that Yap1, an effector of Hippo pathway inhibits skeletal development, postnatal
Yujie Deng +6 more
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The chondro-osseous continuum: is it possible to unlock the potential assigned within? [PDF]
, 2018 Endochondral ossification (EO), by which long bones of the axial skeleton form, is a tightly regulated process involving chondrocyte maturation with successive stages of proliferation, maturation, and hypertrophy, accompanied by cartilage matrix ...
Adams +79 more
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Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes [PDF]
The Journal of Cell Biology, 2003 Chondrocyte proliferation and differentiation requires their attachment to the collagen type II–rich matrix of developing bone. This interaction is mediated by integrins and their cytoplasmic effectors, such as the integrin-linked kinase (ILK). To elucidate the molecular mechanisms whereby integrins control these processes, we have specifically ...
Alice Arabian +7 more
openaire +3 more sources
Natriuretic peptide receptors regulate cytoprotective effects in a human ex vivo 3D/bioreactor model [PDF]
, 2013 © 2013 Peake et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Achan, P +8 more
core +2 more sources
Introducing monitoring and automation in cartilage tissue engineering, toward controlled clinical translation [PDF]
, 2011 The clinical application of tissue engineered products requires to be tightly connected with the possibility to control the process, assess graft quality and define suitable release criteria for implantation.
Santoro, Rosaria
core +1 more source
The regulation of differentiation in mesenchymal stem cells [PDF]
, 2010 Peer reviewedPublisher ...
Augello, Andrea, De Bari, Cosimo
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TAZ is required for chondrogenesis and skeletal development
Cell Discovery, 2021 Chondrogenesis is a major contributor to skeletal development and maintenance, as well as bone repair. Transcriptional coactivator with PDZ-binding motif (TAZ) is a key regulator of osteogenesis and adipogenesis, but how TAZ regulates chondrogenesis and ...
Yang Li +3 more
doaj +1 more source
Proliferation and differentiation potential of chondrocytes from osteoarthritic patients [PDF]
Arthritis Research & Therapy, 2005 AbstractAutologous chondrocyte transplantation (ACT) has been shown, in long-term follow-up studies, to be a promising treatment for the repair of isolated cartilage lesions. The method is based on an implantation of in vitro expanded chondrocytes originating from a small cartilage biopsy harvested from a non-weight-bearing area within the joint.
Catherine Bengtsson +7 more
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Cell sources for articular cartilage repair strategies: shifting from mono-cultures to co-cultures [PDF]
, 2013 The repair of articular cartilage is challenging due to the sparse native cell population combined with the avascular and aneural nature of the tissue. In recent years cartilage tissue engineering has shown great promise.
Blitterswijk, C.A. van +4 more
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c-Maf Transcription Factor Regulates ADAMTS-12 Expression in Human Chondrogenic Cells. [PDF]
, 2013 ObjectiveADAMTS (a disintegrin and metalloproteinase with thrombospondin type-1 motif) zinc metalloproteinases are important during the synthesis and breakdown of cartilage extracellular matrix.
Amanatullah, Derek F +4 more
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