Results 41 to 50 of about 48,883 (320)

Role of galectin-3 in bone cell differentiation, bone pathophysiology and vascular osteogenesis [PDF]

, 2017
Galectin-3 is expressed in various tissues, including the bone, where it is considered a marker of chondrogenic and osteogenic cell lineages. Galectin-3 protein was found to be increased in the differentiated chondrocytes of the metaphyseal plate ...
Fantauzzi, Claudia Blasetti, Iacobini, Carla, Menini, Stefano, Pugliese, Giuseppe   +3 more
core   +2 more sources

Preconditioning of mesenchymal stromal cells with low-intensity ultrasound: influence on chondrogenesis and directed SOX9 signaling pathways [PDF]

, 2020
Background: Continuous low-intensity ultrasound (cLIUS) facilitates the chondrogenic differentiation of human mesenchymal stromal cells (MSCs) in the absence of exogenously added transforming growth factor-beta (TGFβ) by upregulating the expression of ...
A Argentaro, A Augello, A Katsumi, A Woods, A Woods, AD Miller, AH Huang, B Yang, BH Choi, C Huang, C Matta, CA Simmons, CB Little, CJ O’Conor, CY Huang, D Schumann, DR Haudenschild, EM Darling, F Dell'Accio, G Coricor, H Sim, H-C Hsu, HJ Kwon, HJ Lee, HJ Lee, J Li, J Puetzer, JC Sng, JD Kisiday, JH Cui, JH Cui, JW Choi, K Ebisawa, K Pelttari, L Bian, Li Ling, LJ Ng, M Shakibaei, M Tsuda, MA Corrigan, MB Mueller, N Fahy, N Thelin, NP Whitney, P Müller, R Ogawa, RL Mauck, RM Delaine-Smith, RS Tigli, S Murakami, S Noriega, S Noriega, S Yamaguchi, SD Cook, SD Cook, T Furumatsu, T Guo, T Ito, T Juhasz, T Nishida, T Sanjukta Guha, TM Louw, V Lefebvre, V Lefebvre, W Huang, W Huang, Z Li, ZJ Zhang   +67 more
core   +2 more sources

Hypoxia-Preconditioned Extracellular Vesicles from Mesenchymal Stem Cells Improve Cartilage Repair in Osteoarthritis

Membranes, 2022
In the past decade, mesenchymal stem cells (MSCs) have been widely used for the treatment of osteoarthritis (OA), and extracellular vesicles (EVs) may play a major role in the efficacy of this treatment.
Bocheng Zhang, Xiaoyuan Tian, Zhenan Qu, Jun Hao, Weiguo Zhang   +4 more
doaj   +1 more source

Genome-wide microRNA and gene analysis of mesenchymal stem cell chondrogenesis identifies an essential role and multiple targets for miR-140-5p [PDF]

, 2015
microRNAs (miRNAs) are abundantly expressed in development where they are critical determinants of cell differentiation and phenotype. Accordingly miRNAs are essential for normal skeletal development and chondrogenesis in particular.
Akiyama, Albers, Baek, Baraniskin, Bartel, Barter, Berschneider, Bhushan, Bi, Boland, Chiang, Chun, DeLise, Djebali, Dongen, Eberhart, Ebert, Feigin, Friedman, Fu, Furumatsu, Golan, Gradus, Grumolato, Hwang, Jenkins, Kai, Kanamori, Karlsen, Karlsson, Kolben, Korinek, Krol, Laine, Lalevee, Li, Li, Liu, Liu, Lyons, Miyaki, Miyaki, Murdoch, Nakamura, Onyekwelu, Pais, Parikh, Pittenger, Radwan, Roelofs, Rui, Schulz, Smyth, Song, Sorrentino, Staines, Sumiyoshi, Swingler, Tardif, Taylor, Tuddenham, Vonk, Wang, Wang, Xu, Yamashita, Yang, Yang, Yano, Yuan, Zeybel, Zhang, Zhang   +72 more
core   +1 more source

Periodic Mechanical Stress INDUCES Chondrocyte Proliferation and Matrix Synthesis via CaMKII-Mediated Pyk2 Signaling

Cellular Physiology and Biochemistry, 2017
Background/Aims: Periodic mechanical stress can promote chondrocyte proliferation and matrix synthesis to improve the quality of tissue-engineered cartilage. Although the integrin β1–ERK1/2 signal cascade has been implicated in periodic mechanical stress-
Wenwei Liang, Zeng Li, Zhen Wang, Jinchun Zhou, Huanghe Song, Shun Xu, Weiding Cui, Qing Wang, Zhefeng Chen, Feng Liu, Weimin Fan   +10 more
doaj   +1 more source

Targeted Deletion of Capn4 in Cells of the Chondrocyte Lineage Impairs Chondrocyte Proliferation and Differentiation [PDF]

Molecular and Cellular Biology, 2010
Calpains are calcium-dependent intracellular cysteine proteases, which include ubiquitously expressed mu- and m-calpains. Both calpains are heterodimers consisting of a large catalytic subunit and a small regulatory subunit. The calpain small subunit encoded by the gene Capn4 directly binds to the intracellular C-terminal tail of the receptor for the ...
A Kashiwagi, Ernestina Schipani, Mikaela J. Fein, Peter A. Greer, Masako Shimada   +4 more
openalex   +4 more sources

Response of human engineered cartilage based on articular or nasal chondrocytes to interleukin-1? and low oxygen [PDF]

, 2011
Previous studies showed that human nasal chondrocytes (HNC) exhibit higher proliferation and chondrogenic capacity as compared to human articular chondrocytes (HAC).
Andrea Barbero, Andrea Osmokrovic, Celeste Scotti, Francine Wolf, Giuseppe M. Peretti, Ivan Martin, Matricali G.A., Sylvie Miot, Wendt D.   +8 more
core   +1 more source

Involvement of α5β1 Integrin in Matrix Interactions and Proliferation of Chondrocytes [PDF]

Journal of Bone and Mineral Research, 1997
Abstract Integrins are cell surface receptors involved in cellular processes including adhesion, migration, and matrix assembly. In the present study, we analyzed the possible involvement of α5β1 integrin in the regulation of chondrocyte adhesion, spreading, and proliferation.
Fujio Suzuki, Motomi Enomoto-Iwamoto, Masahiro Iwamoto, Maurizio Pacifici, Kojiro Kurisu, David Boettiger, Kazuhisa Nakashima, Yoshiki Mukudai   +7 more
openaire   +3 more sources

In vitro ovine articular chondrocyte proliferation: experiments and modelling [PDF]

Cell Proliferation, 2010
AbstractThis study focuses on analysis of in vitro cultures of chondrocytes from ovine articular cartilage. Isolated cells were seeded in Petri dishes, then expanded to confluence and phenotypically characterized by flow cytometry. The sigmoidal temporal profile of total counts was obtained by classic haemocytometry and corresponding cell size ...
G. La Nasa, Sarah Fadda, Luisa Mancuso, Margarete Arras, Giacomo Cao, Giacomo Cao, Massimo Pisu, Alberto Cincotti, M. I. Liuzzo, Alessandro Concas   +9 more
openaire   +4 more sources

Effect of Oxygen Tension on Tissue-Engineered Human Nasal Septal Chondrocytes

Allergy & Rhinology, 2014
Tissue-engineered nasal septal cartilage may provide a source of autologous tissue for repair of craniofacial defects. Although advances have been made in manipulating the chondrocyte culture environment for production of neocartilage, consensus on the ...
Chih-Wen Twu M.D., Marsha S. Reuther M.D., Kristen K. Briggs Ph.D., Robert L. Sah M.D. Sc.D., Koichi Masuda M.D., Deborah Watson M.D. F.A.C.S.   +5 more
doaj   +1 more source