Results 51 to 60 of about 48,883 (320)

Integrin β1 Gene Therapy Enhances in Vitro Creation of Tissue-Engineered Cartilage Under Periodic Mechanical Stress

Cellular Physiology and Biochemistry, 2015
Background/Aims: Periodic mechanical stress activates integrin β1-initiated signal pathways to promote chondrocyte proliferation and matrix synthesis. Integrin β1 overexpression has been demonstrated to play important roles in improving the activities ...
Wenwei Liang, Chunhui Zhu, Feng Liu, Weiding Cui, Qing Wang, Zhefeng Chen, Qijia Zhou, Shun Xu, Chenjun Zhai, Weimin Fan   +9 more
doaj   +1 more source

Chondrocyte Spheroids Laden in GelMA/HAMA Hybrid Hydrogel for Tissue-Engineered Cartilage with Enhanced Proliferation, Better Phenotype Maintenance, and Natural Morphological Structure

Gels, 2021
Three-dimensional cell-laden tissue engineering has become an extensive research direction. This study aimed to evaluate whether chondrocyte spheroids (chondro-spheroids) prepared using the hanging-drop method could develop better cell proliferation and ...
Guanhuier Wang, Yang An, Xinling Zhang, Pengbing Ding, Hongsen Bi, Zhenmin Zhao   +5 more
doaj   +1 more source

Retrotransposon Expression Is Upregulated in Adulthood and Suppressed during Regeneration of the Limb in the Axolotl (Ambystoma mexicanum)

Advanced Biology, EarlyView.
The axolotl's remarkable regenerative abilities decline with age, the causes may include the numerous repetitive elements within its genome. This study uncovers how Ty3 retrotransposons and coexpression networks involving muscle and immune pathways respond to aging and regeneration, suggesting that transposons respond to physiological shifts and may ...
Samuel Ruiz‐Pérez, Nicolás Alcaraz, Karla Torres‐Arciga, José Antonio Ocampo‐Cervantes, Alejandra Cervera, Clementina Castro‐Hernández, Cynthia Gabriela Sámano‐Salazar, Ernesto Soto‐Reyes, Rodrigo González‐Barrios   +8 more
wiley   +1 more source

Primary cilia elongation in response to interleukin-1 mediates the inflammatory response [PDF]

, 2012
Primary cilia are singular, cytoskeletal organelles present in the majority of mammalian cell types where they function as coordinating centres for mechanotransduction, Wnt and hedgehog signalling. The length of the primary cilium is proposed to modulate
A. K. T. Wann, AC Lin, AJ Espanol, AM Malone, BD Engel, BK Yoder, CA Dinarello, CG Jensen, CM Asleson, D Qian, DA Lee, E Verghese, E Verghese, EJ Michaud, EM Mokrzan, GJ Pazour, H Tukachinsky, I Memon, J Kim, JA Deane, JL Rosenbaum, JM Neugebauer, K Gardner, KJ Palmer, L Schneider, M Barzi, M Cao, M. M. Knight, MA Lancaster, MB Hovater, N Sharma, P Tummala, PA Lefebvre, PV Tran, RY Kwon, S Abdul-Majeed, S Agarwal, S Kim, S Massinen, S Mukhopadhyay, S Pritchard, S Toffoli, SC Goetz, SM Nauli, SR McGlashan, SR McGlashan, SR McGlashan, TT Chowdhury, TY Besschetnova, Y Chen, Y Ou, YH Choi   +51 more
core   +2 more sources

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Novel Biologically Active Glass Fiber Functionalized Using Magnesium Phosphate Cement Promotes Bone and Vascular Regeneration

Advanced Biology, EarlyView.
In this study, a new type of bioactive glass fiber ‐based composite magnesium phosphate bone cement is prepared and verified that its mechanical strength and biological properties. In addition, the cement may have played a biologically active role in the Notch and HIF signaling pathways.
Yuzheng Lu, Yanbo Shan, Yingjie Xiong, Jianting Ye, Yanbin Wu, Jipeng Song, Yao Zhang, Wancheng Lin, Haoye Meng, Wenjing Xu, Jiang Peng, Qiang Lu, Lixiang Ding   +12 more
wiley   +1 more source

KIF22 regulates mitosis and proliferation of chondrocyte cells

iScience
Point mutations in KIF22 have been linked to spondyloepimetaphyseal dysplasia with joint laxity, type 2 (SEMDJL2). Skeletal features of SEMDJL2 include short stature and joint laxity. Mechanisms underlying these limb abnormalities are unknown. Here in this manuscript, we have investigated the function of KIF22 in chondrocytes.
Hiroka Kawaue, Takuma Matsubara, Kenichi Nagano, Aoi Ikedo, Thira Rojasawasthien, Anna Yoshimura, Chihiro Nakatomi, Yuuki Imai, Yoshimitsu Kakuta, William N. Addison, Shoichiro Kokabu   +10 more
openaire   +3 more sources

Chemical modification of extracellular matrix by cold atmospheric plasma-generated reactive species affects chondrogenesis and bone formation. [PDF]

, 2016
The goal of this study was to investigate whether cold plasma generated by dielectric barrier discharge (DBD) modifies extracellular matrices (ECM) to influence chondrogenesis and endochondral ossification.
Chernets, Natalie, Dobrynin, Danil, Eisenhauer, Peter, Freeman, Theresa A., Pleshko, Nancy, Song, You, Steinbeck, Marla J   +6 more
core   +2 more sources

A Vascularized Microphysiological System Reproducing Endochondral Ossification in Vitro to Study Ewing Sarcoma Proliferation and Migration

Advanced Functional Materials, EarlyView.
A biofabricated 3D in vitro model recapitulating endochondral ossification (ECO) is described, mimicking the steps from condensation to chondrogenesis and hypertrophy, culminating with vascularization of the hypertrophic construct. As a model proof of concept application, Ewing Sarcoma cells are seeded in the model, showing modifications in their ...
Maria Vittoria Colombo, Chiara Arrigoni, Tobias Faehling, Antonietta Verrillo, Viviana Secci, Thomas G. P. Grünewald, Giuseppe Talò, Alexandra Kummer, Jorge Gonzalez, Vincenzo De Rosa, Christian Candrian, Andrea Barbero, Florencia Cidre‐Aranaz, Matteo Moretti   +13 more
wiley   +1 more source

mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation

Nature Communications, 2016
mTORC1 is crucial for chondrocyte proliferation and bone growth, but the downstream signalling is not clear. Here, the authors use rapamycin and chondrocyte-specific Tsc1 knockout mice to show that S6K1 can cause nuclear accumulation of Gli2, thus ...
Bo Yan, Zhongmin Zhang, Dadi Jin, Chen Cai, Chunhong Jia, Wen Liu, Ting Wang, Shengfa Li, Haiyan Zhang, Bin Huang, Pinglin Lai, Hua Wang, Anling Liu, Chun Zeng, Daozhang Cai, Yu Jiang, Xiaochun Bai   +16 more
doaj   +1 more source