Results 61 to 70 of about 1,182,907 (370)

Proliferation and differentiation potential of chondrocytes from osteoarthritic patients [PDF]

Arthritis Research & Therapy, 2005
AbstractAutologous chondrocyte transplantation (ACT) has been shown, in long-term follow-up studies, to be a promising treatment for the repair of isolated cartilage lesions. The method is based on an implantation of in vitro expanded chondrocytes originating from a small cartilage biopsy harvested from a non-weight-bearing area within the joint.
Tallheden, Tommi, Bengtsson, Catherine, Brantsing, Camilla, Sjögren-Jansson, Eva, Carlsson, Lars, Peterson, Lars, Brittberg, Mats, Lindahl, Anders   +7 more
openaire   +2 more sources

Hypoxia-Preconditioned Extracellular Vesicles from Mesenchymal Stem Cells Improve Cartilage Repair in Osteoarthritis

Membranes, 2022
In the past decade, mesenchymal stem cells (MSCs) have been widely used for the treatment of osteoarthritis (OA), and extracellular vesicles (EVs) may play a major role in the efficacy of this treatment.
Bocheng Zhang, Xiaoyuan Tian, Zhenan Qu, Jun Hao, Weiguo Zhang   +4 more
doaj   +1 more source

Glucosamine modulates chondrocyte proliferation, matrix synthesis, and gene expression [PDF]

Osteoarthritis and Cartilage, 2007
To investigate the effects of glucosamine (GlcN) on chondrocyte proliferation, matrix production, and gene expression for providing insights into the biochemical basis of its reported beneficial effects in osteoarthritis (OA).Dose-dependent effect of GlcN on cell morphology, proliferation, cartilage matrix production and gene expression was examined by
Varghese, S., Theprungsirikul, P., Sahani, S., Hwang, N., Yarema, K.J., Elisseeff, J.H.   +5 more
openaire   +2 more sources

Primary cilia elongation in response to interleukin-1 mediates the inflammatory response [PDF]

, 2012
Primary cilia are singular, cytoskeletal organelles present in the majority of mammalian cell types where they function as coordinating centres for mechanotransduction, Wnt and hedgehog signalling. The length of the primary cilium is proposed to modulate
A. K. T. Wann, AC Lin, AJ Espanol, AM Malone, BD Engel, BK Yoder, CA Dinarello, CG Jensen, CM Asleson, D Qian, DA Lee, E Verghese, E Verghese, EJ Michaud, EM Mokrzan, GJ Pazour, H Tukachinsky, I Memon, J Kim, JA Deane, JL Rosenbaum, JM Neugebauer, K Gardner, KJ Palmer, L Schneider, M Barzi, M Cao, M. M. Knight, MA Lancaster, MB Hovater, N Sharma, P Tummala, PA Lefebvre, PV Tran, RY Kwon, S Abdul-Majeed, S Agarwal, S Kim, S Massinen, S Mukhopadhyay, S Pritchard, S Toffoli, SC Goetz, SM Nauli, SR McGlashan, SR McGlashan, SR McGlashan, TT Chowdhury, TY Besschetnova, Y Chen, Y Ou, YH Choi   +51 more
core   +2 more sources

Integrin β1 Gene Therapy Enhances in Vitro Creation of Tissue-Engineered Cartilage Under Periodic Mechanical Stress

Cellular Physiology and Biochemistry, 2015
Background/Aims: Periodic mechanical stress activates integrin β1-initiated signal pathways to promote chondrocyte proliferation and matrix synthesis. Integrin β1 overexpression has been demonstrated to play important roles in improving the activities ...
Wenwei Liang, Chunhui Zhu, Feng Liu, Weiding Cui, Qing Wang, Zhefeng Chen, Qijia Zhou, Shun Xu, Chenjun Zhai, Weimin Fan   +9 more
doaj   +1 more source

The viability and proliferation of human chondrocytes following cryopreservation [PDF]

The Journal of Bone and Joint Surgery. British volume, 2008
Human articular cartilage samples were retrieved from the resected material of patients undergoing total knee replacement. Samples underwent automated controlled freezing at various stages of preparation: as intact articular cartilage discs, as minced articular cartilage, and as chondrocytes immediately after enzymatic isolation from fresh articular ...
Xia, Z, Murray, D, Hulley, P, Triffitt, J, Price, A   +4 more
openaire   +6 more sources

IGF-I signalling in bone growth:inhibitory actions of dexamethasone and IL-1beta [PDF]

, 2007
To determine if glucocorticoids and proinflammatory cytokines inhibit bone growth through a common mechanism involving impaired IGF-I ...
Ahmed, S.F., Ahmed, S.F., Farquharson, C., Macrae, V.E., Mushtaq, T.   +4 more
core   +1 more source

Effect of Oxygen Tension on Tissue-Engineered Human Nasal Septal Chondrocytes

Allergy & Rhinology, 2014
Tissue-engineered nasal septal cartilage may provide a source of autologous tissue for repair of craniofacial defects. Although advances have been made in manipulating the chondrocyte culture environment for production of neocartilage, consensus on the ...
Chih-Wen Twu M.D., Marsha S. Reuther M.D., Kristen K. Briggs Ph.D., Robert L. Sah M.D. Sc.D., Koichi Masuda M.D., Deborah Watson M.D. F.A.C.S.   +5 more
doaj   +1 more source

Octacalcium phosphate crystals directly stimulate expression of inducible nitric oxide synthase through p38 and JNK mitogen-activated protein kinases in articular chondrocytes [PDF]

, 2005
Basic calcium phosphate (BCP) crystals, including hydroxyapatite, octacalcium phosphate (OCP) and carbonate-apatite, have been associated with severe osteoarthritis and several degenerative arthropathies.
Ea, Hang-Korng, Lioté, Frédéric, Rey, Christian, Uzan, Benjamin   +3 more
core   +7 more sources

Does intradiscal steroid injection accelerate the histological degeneration of the human disc?

Osteoporosis and Sarcopenia
Objectives: Intradiscal steroid injection (ISI) use has been proven as a low-risk and rapid treatment for disc degeneration disease (DDD). However, the histological effects of steroids on human discs remain poorly understood. The purpose of this study is
Jin Hwan Kim, Sunhee Chang, Byung Ho Kim, Gyu Heon Lee, Sung Tan Cho   +4 more
doaj   +1 more source