Results 1 to 10 of about 111,929 (303)

Osteoarthritis-Induced Metabolic Alterations of Human Hip Chondrocytes [PDF]

Biomedicines, 2022
Osteoarthritis (OA) alters chondrocyte metabolism and mitochondrial biology. We explored whether OA and non-OA chondrocytes show persistent differences in metabolism and mitochondrial function and different responsiveness to cytokines and cAMP modulators.
Annett Eitner, Simon Sparing, Felix C. Kohler, Sylvia Müller, Gunther O. Hofmann, Thomas Kamradt, Hans-Georg Schaible, Matthias Aurich   +7 more
doaj   +3 more sources

Chondrocytes Transdifferentiate Into Osteoblasts in Endochondral Bone During Development, Postnatal Growth and Fracture Healing in Mice [PDF]

PLoS Genetics, 2014
One of the crucial steps in endochondral bone formation is the replacement of a cartilage matrix produced by chondrocytes with bone trabeculae made by osteoblasts. However, the precise sources of osteoblasts responsible for trabecular bone formation have
Benoit De Crombrugghe, Klaus von der Mark, William Norton   +2 more
exaly   +2 more sources

The hypertrophic chondrocyte: To be or not to be.

Histology and histopathology, 2021
Hypertrophic chondrocytes are the master regulators of endochondral ossification; however, their ultimate cell fates cells remain largely elusive due to their transient nature. Historically, hypertrophic chondrocytes have been considered as the terminal state of growth plate chondrocytes, which are destined to meet their inevitable demise at the ...
Hallett, Shawn A., Ono, Wanida, Ono, Noriaki   +2 more
openaire   +3 more sources

Combination of chondrocytes and chondrons improves extracellular matrix production to promote the repairs of defective knee cartilage in rabbits

Journal of Orthopaedic Translation, 2021
Background: Chondrons are composed of chondrocytes and the surrounding pericellular matrix (PCM) and function to enhance chondrocyte-mediated cartilage tissue engineering.
Wangping Duan, Yu Zhao, Xiaochun Ren, Ruipeng Zhao, Qi Li, Zhenwei Sun, Wenjie Song, Yanfei Yang, Pengcui Li, Xiaochun Wei   +9 more
doaj   +1 more source

The Potential of Pulsed Low Intensity Ultrasound to stimulate Chondrocytes in a 3D Model System [PDF]

, 2009
PhDPulsed low intensity ultrasound (PLIUS) is used clinically to accelerate fracture healing. although the mode of action is unclear. However studies suggest that PLIUS may stimulate endochondral ossification and consequently PLIUS may also be ...
Vaughan, Natalie Marlene
core   +4 more sources

miR-107 affects cartilage matrix degradation in the pathogenesis of knee osteoarthritis by regulating caspase-1

Journal of Orthopaedic Surgery and Research, 2021
Background Knee osteoarthritis (KOA) seriously affects the quality of life of KOA patients. This study aimed to investigate whether miR-107 could regulate KOA through pyroptosis to affect collagen protein secreted by chondrocytes through IL-1β.
Jiatian Qian, Peiliang Fu, Shiao Li, Xiang Li, Yancheng Chen, Zhenen Lin   +5 more
doaj   +1 more source

Effect of growth hormone releasing hormone on chondrocytes of osteoarthritis [PDF]

The Korean Journal of Internal Medicine, 2022
Background/Aims To evaluate the effect and possible mechanism of growth hormone releasing hormone (GHRH) on chondrocytes of osteoarthritis (OA). Methods Articular chondrocytes were cultured and the expression of GHRH receptor in chondrocytes was detected.
Zhuoran LI, Yao LI
doaj   +1 more source

Dysregulation of Cells Cycle and Apoptosis in Human Induced Pluripotent Stem Cells Chondrocytes Through p53 Pathway by HT-2 Toxin: An in vitro Study

Frontiers in Genetics, 2021
Kashin–Beck disease (KBD) mainly damages growth plate of adolescents and is susceptible to both gene and gene–environmental risk factors. HT-2 toxin, which is a primary metabolite of T-2 toxin, was regarded as one of the environmental risk factors of KBD.
Yanan Zhang, Yanan Zhang, Huan Liu, Huan Liu, Xialu Lin, Xialu Lin, Feng’e Zhang, Feng’e Zhang, Peilin Meng, Peilin Meng, Sijia Tan, Sijia Tan, Mikko J. Lammi, Mikko J. Lammi, Xiong Guo, Xiong Guo   +15 more
doaj   +1 more source

Histological analysis of the spatio-temporal development of porcine knee cartilage in embryonic and early postnatal stages. [PDF]

Animal Model Exp Med
This study dynamically charts the developmental process of the knee joint cartilage from the embryonic stage through to postnatal life, revealing key developmental events including the origin of knee joint development, chondrification, primary ossification, secondary ossification, formation of the cartilage cancal, and formation of the growth plate. It
Nie Y, Wang K, Wang X, Jing J, Liang Z, Yan G, Guo WF, Zhang M, Zhang W, Xiang L.   +9 more
europepmc   +2 more sources

Flightless I is a catabolic factor of chondrocytes that promotes hypertrophy and cartilage degeneration in osteoarthritis

iScience, 2021
Summary: Synovial macrophages that are activated by cartilage fragments initiate synovitis, a condition that promotes hypertrophic changes in chondrocytes leading to cartilage degeneration in OA.
Taku Ebata, Mohamad Alaa Terkawi, Masanari Hamasaki, Gen Matsumae, Tomohiro Onodera, Mahmoud Khamis Aly, Shunichi Yokota, Hend Alhasan, Tomohiro Shimizu, Daisuke Takahashi, Kentaro Homan, Ken Kadoya, Norimasa Iwasaki   +12 more
doaj   +1 more source