Results 1 to 10 of about 148,259 (356)

Effect of age and cytoskeletal elements on the indentation-dependent mechanical properties of chondrocytes. [PDF]

open access: yesPLoS ONE, 2013
Articular cartilage chondrocytes are responsible for the synthesis, maintenance, and turnover of the extracellular matrix, metabolic processes that contribute to the mechanical properties of these cells.
Nadeen O Chahine   +5 more
doaj   +13 more sources

Chondrocyte Heterogeneity; It Is the Time to Update the Understanding of Cartilage Histology [PDF]

open access: yesSVU-International Journal of Veterinary Sciences (2018), 2018
Chondrocytes were described as one cell populations in most cartilage literature. Two different chondrocyte populations; dark and light, were described in the articular cartilage and a third population, adipochondrocytes, was described in the elastic cartilage.
Yasser A. Ahmed
arxiv   +3 more sources

Decoding Cytokine Dynamics: Wharton's Jelly Stromal Cells and Chondro-Differentiates in PHA-Stimulated Co-Culture. [PDF]

open access: yesCells
Introduction: Articular cartilage damage presents a significant clinical challenge, with limited options for effective regeneration. Mesenchymal stromal cells (MSCs) derived from Wharton’s jelly (WJ) are a promising cell source for cartilage repair due ...
Meenakshi Sundaram RS   +10 more
europepmc   +2 more sources

Osteoarthritis-Induced Metabolic Alterations of Human Hip Chondrocytes

open access: yesBiomedicines, 2022
Osteoarthritis (OA) alters chondrocyte metabolism and mitochondrial biology. We explored whether OA and non-OA chondrocytes show persistent differences in metabolism and mitochondrial function and different responsiveness to cytokines and cAMP modulators.
Annett Eitner   +7 more
doaj   +1 more source

miR-107 affects cartilage matrix degradation in the pathogenesis of knee osteoarthritis by regulating caspase-1

open access: yesJournal of Orthopaedic Surgery and Research, 2021
Background Knee osteoarthritis (KOA) seriously affects the quality of life of KOA patients. This study aimed to investigate whether miR-107 could regulate KOA through pyroptosis to affect collagen protein secreted by chondrocytes through IL-1β.
Jiatian Qian   +5 more
doaj   +1 more source

Effect of growth hormone releasing hormone on chondrocytes of osteoarthritis [PDF]

open access: yesThe Korean Journal of Internal Medicine, 2022
Background/Aims To evaluate the effect and possible mechanism of growth hormone releasing hormone (GHRH) on chondrocytes of osteoarthritis (OA). Methods Articular chondrocytes were cultured and the expression of GHRH receptor in chondrocytes was detected.
Zhuoran LI, Yao LI
doaj   +1 more source

Dysregulation of Cells Cycle and Apoptosis in Human Induced Pluripotent Stem Cells Chondrocytes Through p53 Pathway by HT-2 Toxin: An in vitro Study

open access: yesFrontiers in Genetics, 2021
Kashin–Beck disease (KBD) mainly damages growth plate of adolescents and is susceptible to both gene and gene–environmental risk factors. HT-2 toxin, which is a primary metabolite of T-2 toxin, was regarded as one of the environmental risk factors of KBD.
Yanan Zhang   +15 more
doaj   +1 more source

Chondrocytes in the resting zone of the growth plate are maintained in a Wnt-inhibitory environment

open access: yeseLife, 2021
Chondrocytes in the resting zone of the postnatal growth plate are characterized by slow cell cycle progression, and encompass a population of parathyroid hormone-related protein (PTHrP)-expressing skeletal stem cells that contribute to the formation of ...
Shawn A Hallett   +10 more
doaj   +1 more source

Chondrocytes isolation from hyaline cartilage by continuous monitoring method [PDF]

open access: yesThe Moldovan Medical Journal, 2021
Background: Articular cartilage has poor regenerative capacities. Numerous cartilage repair techniques are known, including implantation of autologous chondrocytes.
Vitalie Cobzac   +3 more
doaj   +1 more source

Chondrocytes transdifferentiate into osteoblasts in endochondral bone during development, postnatal growth and fracture healing in mice. [PDF]

open access: yesPLoS Genetics, 2014
One of the crucial steps in endochondral bone formation is the replacement of a cartilage matrix produced by chondrocytes with bone trabeculae made by osteoblasts. However, the precise sources of osteoblasts responsible for trabecular bone formation have
Xin Zhou   +5 more
doaj   +1 more source

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