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Chondrocytes Transdifferentiate into Osteoblasts in Endochondral Bone during Development, Postnatal Growth and Fracture Healing in Mice [PDF]
PLoS Genetics, 2014 One of the crucial steps in endochondral bone formation is the replacement of a cartilage matrix produced by chondrocytes with bone trabeculae made by osteoblasts. However, the precise sources of osteoblasts responsible for trabecular bone formation have
Benoit De Crombrugghe
exaly +3 more sources
LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis
Nature Communications, 2020 The contribution of inflammation to the chronic joint disease osteoarthritis (OA) is unclear, and this lack of clarity is detrimental to efforts to identify therapeutic targets.
Manoj Arra +2 more
exaly +2 more sources
Glycolytic reprogramming impairs chondrocyte function in broilers with femoral head necrosis [PDF]
Veterinary QuarterlyCartilage extracellular matrix (ECM) destruction is a hallmark of femoral head necrosis (FHN) in broilers. Chondrocytes undergo metabolic reprogramming under stress to maintain function.
Hongfan Ge +3 more
doaj +2 more sources
Mechanical confinement regulates cartilage matrix formation by chondrocytes
Nature Materials, 2017 Cartilage tissue equivalents formed from hydrogels containing chondrocytes could provide a solution for replacing damaged cartilage. Previous approaches have often utilized elastic hydrogels.
Hong-Pyo Lee, Luo Gu, David J Mooney
exaly +2 more sources
Insights on Molecular Mechanisms of Chondrocytes Death in Osteoarthritis
International Journal of Molecular Sciences, 2016 Osteoarthritis (OA) is a joint pathology characterized by progressive cartilage degradation. Medical care is mainly based on alleviating pain symptoms.
Biserka Relic, Céline Deroyer
exaly +2 more sources
Journal of Developmental Biology, 2015 Articular cartilage (AC) covers the diarthrodial joints and is responsible for the mechanical distribution of loads across the joints. The majority of its structure and function is controlled by chondrocytes that regulate Extracellular Matrix (ECM ...
Hemanth Akkiraju
exaly +2 more sources
HIF-1α metabolically controls collagen synthesis and modification in chondrocytes
Nature, 2019 Steve Stegen +2 more
exaly +2 more sources
Osteoarthritis-Induced Metabolic Alterations of Human Hip Chondrocytes
Biomedicines, 2022 Osteoarthritis (OA) alters chondrocyte metabolism and mitochondrial biology. We explored whether OA and non-OA chondrocytes show persistent differences in metabolism and mitochondrial function and different responsiveness to cytokines and cAMP modulators.
Annett Eitner +7 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Osteoarthritis is a global health problem that affects load-bearing joints, causing loss of mobility and enormous healthcare costs. However, disease-modifying approaches are lacking.
Whasil Lee +9 more
semanticscholar +1 more source
Journal of Cellular and Molecular Medicine, 2021 Temporomandibular joint (TMJ) osteoarthritis is a common chronic degenerative disease of the TMJ. In order to explore its aetiology and pathological mechanism, many animal models and cell models have been constructed to simulate the pathological process ...
Baochao Li +4 more
semanticscholar +1 more source